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Find hotels in Sikeston, MO from SAR 219
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Compare 265 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
9.0 out of 10, Wonderful, (550)
The price is SAR 322
SAR 349 total
includes taxes & fees
5 Jun - 6 Jun

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
9.6 out of 10, Exceptional, (1009)
The price is SAR 338
SAR 381 total
includes taxes & fees
18 May - 19 May

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
9.4 out of 10, Exceptional, (1003)
The price is SAR 371
SAR 419 total
includes taxes & fees
18 May - 19 May

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau
9.4 out of 10, Exceptional, (103)
The price is SAR 315
SAR 355 total
includes taxes & fees
18 May - 19 May

The Riverview
The Riverview
9.2 out of 10, Wonderful, (258)
The price is SAR 462
SAR 522 total
includes taxes & fees
25 May - 26 May

Tru By Hilton Cape Girardeau
Tru By Hilton Cape Girardeau
9.8 out of 10, Exceptional, (13)
The price is SAR 379
SAR 432 total
includes taxes & fees
18 May - 19 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Sikeston and related destinations
Explore Sikeston: its food, riverfront, museums, and more!

Photo by Ryan Coleman
Open Photo by Ryan Coleman
Explore the historic buildings and museums of this delightful South Carolina city that’s also known for its nature trails and outdoor pursuits.

Once a Mexican migrant settlement, this Californian town is located on the edge of one of the most important wetland regions in North America.

Photo by Jess. LongestBusRide
Open Photo by Jess. LongestBusRide
Experience romantic Olive Branch: its food, entertainment, hockey, and more!
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Photo by throwingsofas
Open Photo by throwingsofas
More cheap stays in Sikeston
More cheap stays in Sikeston

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
The price is SAR 303 per night from Jun 1 to Jun 2
SAR 303
SAR 345 total
1 Jun - 2 Jun
includes taxes & fees
7.2/10 Good! (1,002 reviews)
Hotels in Sikeston with star-rating
Hotels in Sikeston with star-rating

4 Star Hotels
2 properties
Stay near popular Sikeston attractions
Stay near popular Sikeston attractions
The Book Bug
4/5(5 reviews)
Take the family on an outing to The Book Bug during your trip to Miner. While in this relaxing area, you can savor the top-notch restaurants.
Recent reviews of Sikeston hotels
Recent reviews of Sikeston hotels

Best Western Plus Sikeston
5/5 Excellent
"Our room was very nice and clean. We did not have any noise distractions. The breakfast was good and had several options. The front desk staff that checked us in was very welcoming. The only thing that was not the best was that we realized the morning we checked out that our door didn't lock from the outside."
A verified traveler stayed at Best Western Plus Sikeston
Posted 2 days ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Stay near popular Sikeston attractions
- Hotels near The Book Bug
- Hotels near Sikeston Depot Museum
- Hotels near Central Park
- Hotels near Boot Heel Golf Club
- Hotels near Shawnee National Forest
- Hotels near Mississippi River
- Hotels near Ohio River
- Hotels near Southeast Missouri State University
- Hotels near Riverfront Bridge Park
- Hotels near Riverfront Park
- Hotels near Big Oak Tree State Park
- Hotels near The Heritage House
- Hotels near eDen Spa & Salon
- Hotels near Mound City National Cemetery
- Hotels near Fort Defiance State Park
- Hotels near Stoddard County Civil War Memorial Cemetery
- Hotels near Dexter Welcome Center Depot and Museum
- Hotels near Marston Community Center
- Hotels near Fort D Historic Site
- Hotels near New Madrid Historical Museum
More Hotel Options in Sikeston
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Sikeston Hotels by Brand
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Explore more hotels
- Drury Plaza Hotel Cape Girardeau Conference Center
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
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