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Compare 15,553 hotels close to Mississippi River with room rates, reviews, and availability. Most hotels are fully refundable.

River's Edge Motel
River's Edge Motel
8.8 out of 10, Excellent, (315)
The price is SAR 281
SAR 319 total
includes taxes & fees
28 Mar - 29 Mar

Lighthouse Hospitality Hannibal
Lighthouse Hospitality Hannibal
9.2 out of 10, Wonderful, (106)
The price is SAR 525
SAR 732 total
includes taxes & fees
25 Mar - 26 Mar

Sleep Inn & Suites
Sleep Inn & Suites
9.6 out of 10, Exceptional, (1009)
The price is SAR 402
SAR 461 total
includes taxes & fees
13 Apr - 14 Apr

Best Western On The River
Best Western On The River
8.6 out of 10, Excellent, (1009)
The price is SAR 401
SAR 461 total
includes taxes & fees
25 Mar - 26 Mar

Garden House Bed and Breakfast
Garden House Bed and Breakfast
8.4 out of 10, Very Good, (15)
The price is SAR 402
SAR 461 total
includes taxes & fees
26 Mar - 27 Mar

The Eagles Nest Inn
The Eagles Nest Inn
10.0 out of 10, Exceptional, (1)
The price is SAR 354
SAR 402 total
includes taxes & fees
26 Mar - 27 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Hotels near Other Attractions
Hotels near Other Attractions

Bluff City Theater
Enjoy a show at Bluff City Theater, a theater with a story to tell in Hannibal. While in this walkable area, you can savor the top-notch restaurants.
Recent reviews of Mississippi River hotels
Recent reviews of Mississippi River hotels

21C Museum Hotel St Louis
5/5 Excellent
"Welcoming, kind staff. So enjoyed our stay."
A verified traveler stayed at 21C Museum Hotel St Louis
Posted 7 hours ago
Explore a world of travel with Expedia
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