Photo by Ryan Coleman
Find 4 Star Hotels in Sikeston, MO from SAR 630
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Sikeston 4 Star Hotels
Tonight
Tomorrow
Next weekend
In two weeks
Compare Sikeston 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Davie School Inn
Davie School Inn
10.0 out of 10, Exceptional, (47)
The price is SAR 630
SAR 699 total
includes taxes & fees
16 Mar - 17 Mar

Urban Lofts
Urban Lofts
Save an average of 15% on thousands of hotels when you're signed in
Sikeston and related destinations
Explore Sikeston: its food, riverfront, museums, and more!

Photo by Ryan Coleman
Open Photo by Ryan Coleman
Explore the historic buildings and museums of this delightful South Carolina city that’s also known for its nature trails and outdoor pursuits.

Once a Mexican migrant settlement, this Californian town is located on the edge of one of the most important wetland regions in North America.

Photo by Jess. LongestBusRide
Open Photo by Jess. LongestBusRide
Experience romantic Olive Branch: its food, entertainment, live music, and more!
Lima awaits: its university life, food, cathedral, and more!

Photo by throwingsofas
Open Photo by throwingsofas
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Sikeston Hotels by Star Rating
Stay near popular Sikeston attractions
- Hotels near Boot Heel Golf Club
- Hotels near The Book Bug
- Hotels near Sikeston Depot Museum
- Hotels near Central Park
- Hotels near Shawnee National Forest
- Hotels near Mississippi River
- Hotels near Ohio River
- Hotels near Southeast Missouri State University
- Hotels near Riverfront Bridge Park
- Hotels near Riverfront Park
- Hotels near Big Oak Tree State Park
- Hotels near Mound City National Cemetery
- Hotels near Fort Defiance State Park
- Hotels near eDen Spa & Salon
- Hotels near New Madrid Historical Museum
- Hotels near Fort D Historic Site
- Hotels near Stoddard County Civil War Memorial Cemetery
- Hotels near River Ridge Winery
- Hotels near Dexter Welcome Center Depot and Museum
- Hotels near The Heritage House
More Hotel Options in Sikeston
- Adults Only Resorts & Hotels in Sikeston
- Adventure Hotels in Sikeston
- Business Hotels in Sikeston
- Casinos in Sikeston
- Cheap Hotels in Sikeston
- Family Hotels in Sikeston
- Golf Hotels in Sikeston
- Historic Hotels in Sikeston
- Hotel Wedding Venues in Sikeston
- Hotels with Bars in Sikeston
- Hotels with Free Parking in Sikeston
- Hotels with Hot Tubs in Sikeston
- Hotels with WiFi in Sikeston
- Hotels with a Pool in Sikeston
- Hotels with an Indoor Pool in Sikeston
- Hotels with smoking rooms in Sikeston
- Luxury Hotels in Sikeston
- Pet-friendly Hotels in Sikeston
- Resorts & Hotels with Spas in Sikeston
- Romantic Hotels in Sikeston
- Shopping Hotels in Sikeston
- Winery Hotels in Sikeston
Explore more hotels
- The Riverview
- Drury Plaza Hotel Cape Girardeau Conference Center
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
- Pear Tree Inn Cape Girardeau West
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
- Candlewood Suites Cape Girardeau by IHG
- Courtyard by Marriott Cape Girardeau Downtown
- Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Drury Inn & Suites Cape Girardeau
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Quality Inn
- Drury Inn & Suites Jackson MO
- Holiday Inn Express & Suites Perryville by IHG
- Rest, Relax and Renew. Our log cabin experience awaits your arrival.
- New cabin in the woods with private hot tub
- Beautiful location in the secluded woods
- Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery
- Hampton Inn Cape Girardeau I 55 East
- Town House Inn Cape Giradreau