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Compare 561 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar Bluff
9.4 out of 10, Exceptional, (709)
The price is SAR 364
SAR 411 total
includes taxes & fees
4 May - 5 May

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
9.0 out of 10, Wonderful, (527)
The price is SAR 313
SAR 338 total
includes taxes & fees
10 Apr - 11 Apr

Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
9.4 out of 10, Exceptional, (1006)
The price is SAR 321
SAR 369 total
includes taxes & fees
13 Apr - 14 Apr

Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
9.0 out of 10, Wonderful, (1007)
The price is SAR 270
SAR 305 total
includes taxes & fees
5 May - 6 May

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
9.4 out of 10, Exceptional, (916)
The price is SAR 355
SAR 400 total
includes taxes & fees
27 Apr - 28 Apr

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
9.6 out of 10, Exceptional, (1005)
The price is SAR 355
SAR 400 total
includes taxes & fees
13 Apr - 14 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
9.0/10Wonderful (527 reviews)
15% off
Price is SAR 408
per night
SAR 884 total
includes taxes & fees
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Learn more about Southeast Missouri
Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

More cheap stays in Southeast Missouri
More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
The price is SAR 201 per night from Apr 13 to Apr 14
SAR 201
SAR 229 total
includes taxes & fees
13 Apr - 14 Apr
8/10 Very Good! (902 reviews)
Hotels in Southeast Missouri with star-rating
Hotels in Southeast Missouri with star-rating

4 Star Hotels
1 properties
Stay near popular Southeast Missouri attractions
Stay near popular Southeast Missouri attractions

Elephant Rocks State Park
5/5(13 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Recent reviews of Southeast Missouri hotels
Recent reviews of Southeast Missouri hotels

Drury Inn & Suites Cape Girardeau
5/5 Excellent
"5 Stars is not enough for all of the staff on duty April 4th, 2025. These folks are a SOLID 11! There was a genuine tornado approaching and they made sure all the lodgers were in safe spaces and appraised of what was going on. There was no hesitation of what to do, where to go and all was calm. Luckily, all was good.
Oh yeah the dinner & breakfast was great the place was clean and our room was fantastic. Value was excellent.
Allen B."
A verified traveler stayed at Drury Inn & Suites Cape Girardeau
Posted 2 days ago
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Hotels in Southeast Missouri Neighborhoods
Stay near popular Southeast Missouri attractions
- Hotels near Elephant Rocks State Park
- Hotels near Johnson's Shut-ins State Park
- Hotels near Southeast Missouri State University
- Hotels near Ozark National Scenic Riverways
- Hotels near Echo Bluff State Park
- Hotels near Lake Wappapello
- Hotels near Isle Casino Cape Girardeau
- Hotels near Alley Spring & Mill
- Hotels near Big Spring
- Hotels near Century Casino Caruthersville
- Hotels near Bonne Terre Mine
- Hotels near Current River State Park
- Hotels near Taum Sauk Mountain State Park
- Hotels near Sainte Genevieve Winery
- Hotels near Hunter Valley Winery
- Hotels near Rocky Falls
- Hotels near K Bridge Recreation Area
- Hotels near Crown Valley Winery
- Hotels near Black River Coliseum
- Hotels near National Shrine of Our Lady of the Miraculous Medal
More Hotel Options in Southeast Missouri
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- Hotel Wedding Venues in Southeast Missouri
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- Hotels with Free Parking in Southeast Missouri
- Hotels with Hot Tubs in Southeast Missouri
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- Hotels with WiFi in Southeast Missouri
- Hotels with a Pool in Southeast Missouri
- Hotels with an Indoor Pool in Southeast Missouri
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- Pet-friendly Hotels in Southeast Missouri
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- Ski Hotels in Southeast Missouri
- Winery Hotels in Southeast Missouri
More Accommodation Types in Southeast Missouri
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Hotels near Southeast Missouri Airports
Southeast Missouri Hotels by Brand
Other Hotels near Southeast Missouri, Missouri
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Explore more hotels
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