Photo by Ryan Coleman

Find Luxury Hotels in Sikeston, MO

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Compare Sikeston Luxury Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Days Inn and Suites by Wyndham Sikeston
Room

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1005)
"Nice place. Quiet. God breakfest"
The price is SAR 236
SAR 269 total
includes taxes & fees
13 Jan - 14 Jan
Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1002)
"I stayed one night on my travels and the staff was friendly, room was clean, and there are a lot of dining options in the area."
The price is SAR 220
SAR 248 total
includes taxes & fees
23 Jan - 24 Jan
Pear Tree Inn Cape Girardeau Near the Medical Center
Quality Inn
Exterior

Quality Inn

2.5 star property
7.0 out of 10, Good, (534)
"It was very nice"
The price is SAR 228
SAR 257 total
includes taxes & fees
9 Feb - 10 Feb
Quality Inn
Drury Inn & Suites Sikeston, MO
Pool

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1004)
"It was a nice a comfortable stay with free breakfast and dinner included. There were even free cocktails. We were very pleased with the food. The pillows and bedding are very comfortable. "
The price is SAR 372
SAR 427 total
includes taxes & fees
24 Jan - 25 Jan
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Cape Girardeau
Exterior

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (869)
"Just remodeled "
The price is SAR 355
SAR 400 total
includes taxes & fees
3 Feb - 4 Feb
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Are you looking for a luxury hotel for your stay in Sikeston?
Use Expedia and let us help you arrange a flight to Cairo, IL (CIR-Cairo Regional) airport or Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Sikeston has to offer. During your visit, you might want to enjoy the shopping which Sikeston is known for.
How many luxury hotels will I find in Sikeston?
Lie in the lap of luxury during your getaway to Sikeston in one of Expedia’s 5 luxury hotels.
When can I expect good weather in Sikeston?
Planning for the weather is a good way to make your trip to Sikeston relaxing and enjoyable, especially when you’re splurging. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.
What's there to see and do in Sikeston?
Experience Sikeston with a stop at The Book Bug, Central Park, and Sikeston Depot Museum. If you have a little extra time during your trip, you might want to make a stop at River Ridge Winery and Boot Heel Golf Club.