Photo by Ryan Coleman

Find Luxury Hotels in Sikeston, MO

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Check availability on Sikeston Luxury Hotels

Compare Sikeston Luxury Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Days Inn and Suites by Wyndham Sikeston
Room

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1001)
"Great room"
The price is SAR 239
SAR 272 total
includes taxes & fees
16 Feb - 17 Feb
Days Inn and Suites by Wyndham Sikeston
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Historical Kage House

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

10.0 out of 10, Exceptional, (209)
"Clean and large space. Easy access to lots of shops and restaurants. Great hosts."
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1001)
" CC"
The price is SAR 219
SAR 247 total
includes taxes & fees
9 Mar - 10 Mar
Pear Tree Inn Cape Girardeau Near the Medical Center
Quality Inn
Exterior

Quality Inn

2.5 star property
7.0 out of 10, Good, (540)
"It was very nice"
The price is SAR 230
SAR 259 total
includes taxes & fees
25 Feb - 26 Feb
Quality Inn
Drury Inn & Suites Sikeston, MO
Pool

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1002)
"Perfect location, love the evening and breakfast meals along with the 3 free drinks "
The price is SAR 371
SAR 427 total
includes taxes & fees
17 Feb - 18 Feb
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Cape Girardeau
Exterior

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (885)
"Nice hotel. Great food & friendly staff. Would stay again."
The price is SAR 354
SAR 400 total
includes taxes & fees
23 Feb - 24 Feb
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Are you looking for a luxury hotel for your stay in Sikeston?
Use Expedia and let us help you arrange a flight to Cairo, IL (CIR-Cairo Regional) airport or Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Sikeston has to offer. During your visit, you might want to enjoy the shopping which Sikeston is known for.
How many luxury hotels will I find in Sikeston?
Lie in the lap of luxury during your getaway to Sikeston in one of Expedia’s 5 luxury hotels.
When can I expect good weather in Sikeston?
Planning for the weather is a good way to make your trip to Sikeston relaxing and enjoyable, especially when you’re splurging. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.
What's there to see and do in Sikeston?
Experience Sikeston with a stop at The Book Bug, Sikeston Depot Museum, and Boot Heel Golf Club. If you have a little extra time during your trip, you might want to make a stop at Stoddard County Civil War Memorial Cemetery and Central Park.