Photo by Ryan Coleman

Find Luxury Hotels in Sikeston, MO

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Check availability on Sikeston Luxury Hotels

Compare Sikeston Luxury Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Days Inn and Suites by Wyndham Sikeston
1 bedroom, desk, laptop workspace, blackout drapes

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1002)
"Very accommodating staff"
The price is SAR 303
SAR 345 total
includes taxes & fees
9 May - 10 May
Days Inn and Suites by Wyndham Sikeston
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Property grounds

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

10.0 out of 10, Exceptional, (214)
"Clean and large space. Easy access to lots of shops and restaurants. Great hosts."
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Pear Tree Inn Cape Girardeau Near the Medical Center
Seasonal outdoor pool

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1002)
"Continental breakfast where the hostess made the waffles for you; friendly staff."
The price is SAR 219
SAR 247 total
includes taxes & fees
11 May - 12 May
Pear Tree Inn Cape Girardeau Near the Medical Center
Quality Inn
Lobby

Quality Inn

2.5 star property
7.0 out of 10, Good, (571)
"Love it very clean and very quiet love the experience"
The price is SAR 240
SAR 271 total
includes taxes & fees
5 May - 6 May
Quality Inn
Drury Inn & Suites Sikeston, MO
Property amenity

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1003)
"Wonder stay! Excellent hotel. "
The price is SAR 371
SAR 427 total
includes taxes & fees
18 May - 19 May
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Cape Girardeau
Business center

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (925)
"Always The best hotel "
The price is SAR 354
SAR 400 total
includes taxes & fees
1 Jun - 2 Jun
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Are you looking for a luxury hotel for your stay in Sikeston?
Use Expedia and let us help you arrange a flight to Cairo, IL (CIR-Cairo Regional) airport or Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Sikeston has to offer. During your visit, you might want to enjoy the shopping which Sikeston is known for.
How many luxury hotels will I find in Sikeston?
Lie in the lap of luxury during your getaway to Sikeston in one of Expedia’s 5 luxury hotels.
When can I expect good weather in Sikeston?
Planning for the weather is a good way to make your trip to Sikeston relaxing and enjoyable, especially when you’re splurging. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.
What's there to see and do in Sikeston?
Experience Sikeston with a stop at Sikeston Depot Museum, Central Park, and The Book Bug. If you have a little extra time during your trip, you might want to make a stop at Boot Heel Golf Club and Front Street Studio & Art Gallery.