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Compare hotels near Cairo Regional airport with room rates, reviews, and updated availability. Most hotels are fully refundable.

Quality Inn Cairo I-57
Quality Inn Cairo I-57
6.6 out of 10, (248)
The price is SAR 319
SAR 354 total
includes taxes & fees
13 Apr - 14 Apr

Eagle Inn Charleston
Eagle Inn Charleston
6.8 out of 10, (95)
The price is SAR 206
SAR 229 total
includes taxes & fees
2 May - 3 May

Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
6.6 out of 10, (548)
The price is SAR 246
SAR 274 total
includes taxes & fees
6 Apr - 7 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Recent reviews of Cairo Regional hotels
Recent reviews of Cairo Regional hotels

Country Yard Inn and Suite
5/5 Excellent
"Nice place excellent service "
A verified traveler stayed at Country Yard Inn and Suite
Posted 1 day ago
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Hotels Close to Nearby Airports
Hotels near popular Cairo Attractions
- Shawnee National Forest
- Mississippi River
- Ohio River
- Southeast Missouri State University
- Isle Casino Cape Girardeau
- Riverfront Bridge Park
- Riverfront Park
- Columbus-Belmont State Park
- Cape Rock Park
- Henry N Barkhausen Cache River Wetlands Center
- Mound City National Cemetery
- eDen Spa & Salon
- The Book Bug
- Fort D Historic Site
- Fort Defiance State Park
- Central Park
- Ullin City Hall
- Sikeston Depot Museum
- Shawnee Community College
- Ballard Wildlife Management Area
Hotel options around Cairo Regional
- Charming 3-bedroom house near ball park in quiet neighborhood
- The Riverview
- Pear Tree Inn Sikeston
- Best Western Plus Sikeston
- Drury Inn & Suites Sikeston, MO
- Days Inn and Suites by Wyndham Sikeston
- Country Yard Inn and Suite
- Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
- Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
- Comfort Inn & Suites Sikeston I-55
- Charming cottage overlooking Lake Acre
- Super 8 by Wyndham Sikeston/Miner Area
- Charming Home just minutes from Interstate and Mall
- Building at Cape Girardeau Regional Airport
- Courtyard by Marriott Cape Girardeau Downtown
- Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.
- Charming 3-bedroom house with WiFi and AC in beautiful Joppa.
- Hampton Inn Sikeston
- Serenity South -- Gardens, River-Views, and Refreshing Space
- River's Dawn - Modernized Historic Home - River Views - King Bed - Fast Wifi