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Compare hotels near Cairo Regional airport with room rates, reviews, and updated availability. Most hotels are fully refundable.

Quality Inn Cairo I-57
Quality Inn Cairo I-57
6.6 out of 10, (250)
The price is SAR 265
SAR 295 total
includes taxes & fees
27 May - 28 May

Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
6.6 out of 10, (552)
The price is SAR 236
SAR 262 total
includes taxes & fees
18 May - 19 May

Eagle Inn Charleston
Eagle Inn Charleston
6.8 out of 10, (96)
The price is SAR 239
SAR 266 total
includes taxes & fees
28 Apr - 29 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Recent reviews of Cairo Regional hotels
Recent reviews of Cairo Regional hotels

The Riverview
5/5 Excellent
"Very clean hotel with bar , restaurant and a casino attached. "
A verified traveler from Germantown stayed at The Riverview
Posted 3 days ago
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Hotels Close to Nearby Airports
Hotels near popular Cairo Attractions
- Shawnee National Forest
- Mississippi River
- Ohio River
- Southeast Missouri State University
- Isle Casino Cape Girardeau
- Riverfront Bridge Park
- Riverfront Park
- Columbus-Belmont State Park
- Henry N Barkhausen Cache River Wetlands Center
- Cape Rock Park
- eDen Spa & Salon
- The Book Bug
- Mound City National Cemetery
- Central Park
- Sikeston Depot Museum
- Ullin City Hall
- Fort Defiance State Park
- Fort D Historic Site
Hotel options around Cairo Regional
- Pear Tree Inn Sikeston
- The Riverview
- Best Western Plus Sikeston
- Drury Inn & Suites Sikeston, MO
- Days Inn and Suites by Wyndham Sikeston
- Country Yard Inn and Suite
- Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
- Comfort Inn & Suites Sikeston I-55
- Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
- Charming cottage overlooking Lake Acre
- Super 8 by Wyndham Sikeston/Miner Area
- Charming Home just minutes from Interstate and Mall
- Building at Cape Girardeau Regional Airport
- Courtyard by Marriott Cape Girardeau Downtown
- Hampton Inn Sikeston
- Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.
- Serenity South -- Gardens, River-Views, and Refreshing Space
- Charming 3-bedroom house with WiFi and AC in beautiful Joppa.
- Little Blue Cottage on Spanish
- River's Dawn - Modernized Historic Home - River Views - King Bed - Fast Wifi