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Compare 76 Vacation Homes in Sikeston with updated reviews, rates, and availability.

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (130)
"When looking for a VRBO for our daughter's college visit, we knew the perfect place to stay! This is our second stay at Serenity South and it was just as incredible as the first visit. Clean, inviting and cozy. Thanks Jo for another beautiful stay."
The price is SAR 563
SAR 919 total
includes taxes & fees
21 Apr - 22 Apr
Serenity South -- Gardens, River-Views, and Refreshing Space

Notting Hill Cottage

9.6 out of 10, Exceptional, (308)
"Wonderful property and near to wineries and state parks. It had everything we needed and we loved the hot tub!"
Notting Hill Cottage

Beautiful location in the secluded woods

9.8 out of 10, Exceptional, (26)
"If you're looking to visit Holy Boulders, this spot gets you within 5-10 minutes of either trailhead. It was clean, roomy, and has everything you need when you're not at the crag."
The price is SAR 409
SAR 679 total
includes taxes & fees
22 Apr - 23 Apr
Beautiful location in the secluded woods

* On the Wine Trail * Hot Tub * Wi-Fi *

9.8 out of 10, Exceptional, (225)
"Property was just as described! Very centrally located on the wine trail and had everything we needed! "
* On the Wine Trail * Hot Tub * Wi-Fi *

Wine Trail, Cozy Cabin plus hot tub

10.0 out of 10, Exceptional, (91)
"This was a good location for exploring southern Illinois and Shawnee National Forest. We enjoyed some hikes with the dog at Giant City State Park before the storms hit. The furnishings were comfortable and the hot tub was a perfect ending to the day."
Wine Trail, Cozy Cabin plus hot tub

* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

10.0 out of 10, Exceptional, (90)
"The place was clean and the host was super nice! We were in town for a wedding at Havisham and this location was perfect! We were able to walk there in just a few minutes!"
The price is SAR 672
SAR 839 total
includes taxes & fees
19 Apr - 20 Apr
* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

Minutes from WineTrail, Giant City, Shawnee Forest - Daily Deer Viewing - Rural

10.0 out of 10, Exceptional, (115)
"My husband and I stayed with our dog at this property and had a wonderful time! We have been to the trail many times during peak season, but decided we wanted to do something a little more lowkey and bring our dog. We spent quite a bit of time in the house, reading, watching TV cooking, and all of the amenities that we needed were there. Communication with the property owner, Steve, was also very easy and he was very responsive.Would recommend this cozy home! "
The price is SAR 1,310
SAR 1,641 total
includes taxes & fees
26 Apr - 27 Apr
Minutes from WineTrail, Giant City, Shawnee Forest - Daily Deer Viewing - Rural

Brick Estate with pool in Quiet Carbondale Neighborhood

9.4 out of 10, Exceptional, (84)
"We enjoyed our stay here very much. The home is large yet cozy and located in a lovely quiet neighborhood. Perfect for visiting local family and friends!"
Brick Estate with pool in Quiet Carbondale Neighborhood

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

8.8 out of 10, Excellent, (28)
"all was so nice and we enjoyed our stay. grandkids and us loved having pool table and card games and all the peace and quiet there. thank u again for contacting me and giving us address. we appreciated that very much. "
The price is SAR 563
SAR 880 total
includes taxes & fees
22 Apr - 23 Apr
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

8.0 out of 10, Very Good, (1)
"The house has a very eclectic decor, but fun. We were a group of 10 ladies and had a great time. Thank you "
The price is SAR 1,122
SAR 1,776 total
includes taxes & fees
22 Apr - 23 Apr
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

Dexter Homestead. Very Cozy & NEW Remodel !

8.0 out of 10, Very Good, (22)
"Plenty of room to move about. Quiet neighborhood. Host took care of all our needs."
The price is SAR 371
SAR 770 total
includes taxes & fees
21 Apr - 22 Apr
Dexter Homestead. Very Cozy & NEW Remodel !

Private lake, beach & hot tub, romantic getaway or family vaca

10.0 out of 10, Exceptional, (23)
"We had a funeral in Poplar Bluff and needed a place to stay. This worked well for our family for the few days we stayed. "
Private lake, beach & hot tub, romantic getaway or family vaca

'The Lakehouse' Lovely Wappapello Country Home!

9.8 out of 10, Exceptional, (16)
"Traveled with my two daughters (teens) to visit my mom. The house was perfect for hanging around and visiting with family. Well stocked and good communication from the host. "
'The Lakehouse' Lovely Wappapello Country Home!

Charming 2-bedroom house in delightful Jackson with AC, WiFi

10.0 out of 10, Exceptional, (3)
"We had 4 of us for a 2 night stay. The property is clean, everything looked fresh and welcoming. The house is located about a mile off of hwy 61, so is close to fuel, restaurants, etc. We enjoyed the quiet surroundings."
Charming 2-bedroom house in delightful Jackson with AC, WiFi

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

10.0 out of 10, Exceptional, (5)
"A large and comfortable house with cool historical details and just about everything you need to have a great, easy, smooth-running vacation. Great location for downtown exploring."
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

Quaint, Beautiful Home next to SEMO and Hospital

9.8 out of 10, Exceptional, (34)
"The home had everything we needed for a relaxing weekend! Owner responded promptly and everything was as it was listed!"
Quaint, Beautiful Home next to SEMO and Hospital

Welcome campers, hikers, fishermen, girls' weekend wine getaways!!

2.0 star property
10.0 out of 10, Exceptional, (9)
"It was exactly what we were looking for and exceeded our expectations. We plan to be back! The hosts were wonderful! "
The price is SAR 750
SAR 927 total
includes taxes & fees
21 Apr - 22 Apr
Welcome campers, hikers, fishermen, girls' weekend wine getaways!!

"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

10.0 out of 10, Exceptional, (14)
"Chip was an excellent host, always available to provide tips about restaurants and answer any questions about the property. Property was in great condition and would not hesitate to recommend."
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

Embers of Murphysboro - 5 Star Cabin Sleeps up to 12 - GREAT AMMENITIES!

10.0 out of 10, Exceptional, (10)
"The property exceeded all of our expectations. We couldn’t have asked for better hosts. "
Embers of Murphysboro - 5 Star Cabin Sleeps up to 12 - GREAT AMMENITIES!

StarView Vineyards Winery Retreat

10.0 out of 10, Exceptional, (33)
"The house was clean and nicely updated. There was plenty of room for us. The area is easily accessible to activities. "
StarView Vineyards Winery Retreat
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Sikeston

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

10.0 out of 10, Exceptional, (377)
"Overall very nice place. Host were great and easy to contact. "
The price is SAR 439
SAR 771 total
includes taxes & fees
27 Apr - 28 Apr
Rest, Relax and Renew. Our log cabin experience awaits your arrival.

New cabin in the woods with private hot tub

10.0 out of 10, Exceptional, (109)
"Great clean cabin in the woods with hot tub clean and nice"
New cabin in the woods with private hot tub

Beautiful location in the secluded woods

9.8 out of 10, Exceptional, (26)
"If you're looking to visit Holy Boulders, this spot gets you within 5-10 minutes of either trailhead. It was clean, roomy, and has everything you need when you're not at the crag."
The price is SAR 409
SAR 679 total
includes taxes & fees
22 Apr - 23 Apr
Beautiful location in the secluded woods
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.