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Compare 76 Vacation Homes in Sikeston with updated reviews, rates, and availability.

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (128)
"When looking for a VRBO for our daughter's college visit, we knew the perfect place to stay! This is our second stay at Serenity South and it was just as incredible as the first visit. Clean, inviting and cozy. Thanks Jo for another beautiful stay."
The price is SAR 563
SAR 919 total
includes taxes & fees
31 Mar - 1 Apr
Serenity South -- Gardens, River-Views, and Refreshing Space

Notting Hill Cottage

9.6 out of 10, Exceptional, (304)
"We stayed here previously but it was under different ownership. The new owners have done a great job of making it really comfortable. It was a perfect spot for us to visit family and have our own space close by."
Notting Hill Cottage

Beautiful location in the secluded woods

9.8 out of 10, Exceptional, (24)
"If you’re looking for a comfortable, relaxing place to stay, look no further! This cute home located right next to Shawnee National Forest was the perfect weekend getaway for us and our dogs. The house is back in the woods with over 8 acres to explore. And the stars at night were incredible! Everything was very clean and our host provided bottled water and had all the makings for coffee. Will definitely stay here again next time we visit!"
Beautiful location in the secluded woods

* On the Wine Trail * Hot Tub * Wi-Fi *

9.8 out of 10, Exceptional, (221)
"Property manager was very communicative when we had something come up last minute. Excellent customer service! Property was very clean, and well decorated. Several locations for food are very close, at least 1-2 in walking distance with good food. "
The price is SAR 709
SAR 888 total
includes taxes & fees
31 Mar - 1 Apr
* On the Wine Trail * Hot Tub * Wi-Fi *

Wine Trail, Cozy Cabin plus hot tub

10.0 out of 10, Exceptional, (87)
"Wonderful! Hope to return sometime in the near future, The yard was so nice for our dogs, Beau and Gracie had so much fun playing ball! Thank you so much for making it pet friendly, we don’t travel without them. All the comforts of home, plus the hot tub!"
Wine Trail, Cozy Cabin plus hot tub

* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

10.0 out of 10, Exceptional, (88)
"Girls trip "
* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

Minutes from WineTrail, Giant City, Shawnee Forest - Daily Deer Viewing - Rural

10.0 out of 10, Exceptional, (115)
"My husband and I stayed with our dog at this property and had a wonderful time! We have been to the trail many times during peak season, but decided we wanted to do something a little more lowkey and bring our dog. We spent quite a bit of time in the house, reading, watching TV cooking, and all of the amenities that we needed were there. Communication with the property owner, Steve, was also very easy and he was very responsive.Would recommend this cozy home! "
The price is SAR 1,309
SAR 1,603 total
includes taxes & fees
26 Apr - 27 Apr
Minutes from WineTrail, Giant City, Shawnee Forest - Daily Deer Viewing - Rural

Brick Estate with pool in Quiet Carbondale Neighborhood

9.4 out of 10, Exceptional, (84)
"We enjoyed our stay here very much. The home is large yet cozy and located in a lovely quiet neighborhood. Perfect for visiting local family and friends!"
Brick Estate with pool in Quiet Carbondale Neighborhood

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

8.8 out of 10, Excellent, (27)
"Amazing property that we simply didn't stay long enough to enjoy in its completeness. Billiards and Putt-Putt on entry, so attractive that we started playing before we even unpacked! I'm very artsy interior, and lots of room and outdoor fire pit, multiple decks, and an in-ground pool. The home is even on the grounds, an event venue. Probably a wonderful combination for them! Would enjoy returning, but for a longer stay will you could enjoy all with the property had to offer! Highly recommend it"
The price is SAR 563
SAR 876 total
includes taxes & fees
7 Apr - 8 Apr
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

"The house has a very eclectic decor, but fun. We were a group of 10 ladies and had a great time. Thank you "
The price is SAR 1,122
SAR 1,775 total
includes taxes & fees
7 Apr - 8 Apr
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

Dexter Homestead. Very Cozy & NEW Remodel !

8.0 out of 10, Very Good, (22)
"Plenty of room to move about. Quiet neighborhood. Host took care of all our needs."
The price is SAR 371
SAR 762 total
includes taxes & fees
7 Apr - 8 Apr
Dexter Homestead. Very Cozy & NEW Remodel !

Private lake, beach & hot tub, romantic getaway or family vaca

10.0 out of 10, Exceptional, (23)
"We had a funeral in Poplar Bluff and needed a place to stay. This worked well for our family for the few days we stayed. "
Private lake, beach & hot tub, romantic getaway or family vaca

'The Lakehouse' Lovely Wappapello Country Home!

9.6 out of 10, Exceptional, (15)
"Traveled with my two daughters (teens) to visit my mom. The house was perfect for hanging around and visiting with family. Well stocked and good communication from the host. "
'The Lakehouse' Lovely Wappapello Country Home!

Charming 2-bedroom house in delightful Jackson with AC, WiFi

10.0 out of 10, Exceptional, (3)
"We had 4 of us for a 2 night stay. The property is clean, everything looked fresh and welcoming. The house is located about a mile off of hwy 61, so is close to fuel, restaurants, etc. We enjoyed the quiet surroundings."
Charming 2-bedroom house in delightful Jackson with AC, WiFi

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

10.0 out of 10, Exceptional, (5)
"A large and comfortable house with cool historical details and just about everything you need to have a great, easy, smooth-running vacation. Great location for downtown exploring."
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

Quaint, Beautiful Home next to SEMO and Hospital

9.8 out of 10, Exceptional, (34)
"The home had everything we needed for a relaxing weekend! Owner responded promptly and everything was as it was listed!"
Quaint, Beautiful Home next to SEMO and Hospital

Welcome campers, hikers, fishermen, girls' weekend wine getaways!!

2.0 star property
10.0 out of 10, Exceptional, (7)
"This place is just what we needed for our snow goose hunting camp! Place was clean and tidy and even had a pool table that made for hours of fun! Host went above and beyond to be helpful and was excellent with communication and was even kind enough to bring us some snow goose summer sausage (which was delicious)! I wouldn't hesitate to stay here again and would recommend it to anyone!!!"
The price is SAR 750
SAR 923 total
includes taxes & fees
1 Apr - 2 Apr
Welcome campers, hikers, fishermen, girls' weekend wine getaways!!

"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

10.0 out of 10, Exceptional, (13)
"Chip was fantastic and went above and beyond to get us acquainted with the property! Fantastic weekend in a beautiful home with family and friends!"
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

Embers of Murphysboro - 5 Star Cabin Sleeps up to 12 - GREAT AMMENITIES!

10.0 out of 10, Exceptional, (8)
"This location was absolutely perfect for a combination of winery tours and hiking. It is tucked away off the road for a wonderful sense of privacy. The overall house was immaculately clean and sparkled just like in the photos. Kitchen was very large with two sink areas for prep. The professional stove took a minute to figure out but then cooking was a breeze. The only issue we had in the kitchen is that we never did figure out how to turn on the lights above the stove. All the bedrooms and...
Embers of Murphysboro - 5 Star Cabin Sleeps up to 12 - GREAT AMMENITIES!

StarView Vineyards Winery Retreat

10.0 out of 10, Exceptional, (33)
"The house was clean and nicely updated. There was plenty of room for us. The area is easily accessible to activities. "
StarView Vineyards Winery Retreat
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Sikeston

Beautiful location in the secluded woods

9.8 out of 10, Exceptional, (24)
"If you’re looking for a comfortable, relaxing place to stay, look no further! This cute home located right next to Shawnee National Forest was the perfect weekend getaway for us and our dogs. The house is back in the woods with over 8 acres to explore. And the stars at night were incredible! Everything was very clean and our host provided bottled water and had all the makings for coffee. Will definitely stay here again next time we visit!"
Beautiful location in the secluded woods

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

10.0 out of 10, Exceptional, (375)
"Everything was perfect,it was a very comfy and cozy cabin,we really enjoyed our getaway here."
The price is SAR 439
SAR 774 total
includes taxes & fees
31 Mar - 1 Apr
Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery

10.0 out of 10, Exceptional, (118)
"Had a nice stay in a cute little cabin in the woods. Only downside I would say is the location, it’s literally a cabin in the woods. Not saying that’s a bad thing, at certain times of the year you may need a 4x4 vehicle to get in and out. We had a little Prius and the roads were a little muddy. Otherwise nothing but great things to say, would return in the future.. would highly recommend the giant state park restaurant, get the chicken!!! Also the iron whisk for a nice breakfast spot. "
Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.