Find hotels in Otay Mesa, San Diego from SAR 270

  • Plan, book, stay with confidence

  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Discover 4,590 Otay Mesa hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
7.6 out of 10, Good, (1414)
"The place was nice to stay every close to the otay board. "
The price is SAR 496
SAR 558 total
includes taxes & fees
27 Apr - 28 Apr
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

2.5 star property
7.2 out of 10, Good, (998)
"location was ok. location is close to cbx"
The price is SAR 372
SAR 419 total
includes taxes & fees
20 Apr - 21 Apr
Quality Suites San Diego Otay Mesa

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1167)
"It's a nice casino."
The price is SAR 360
SAR 441 total
includes taxes & fees
20 Apr - 21 Apr
Sycuan Casino Resort

Days Inn by Wyndham San Diego-East/El Cajon

2.0 star property
7.6 out of 10, Good, (1002)
"Clean and very friendly staff."
The price is SAR 316
SAR 348 total
includes taxes & fees
15 Apr - 16 Apr
Days Inn by Wyndham San Diego-East/El Cajon

Super 8 by Wyndham El Cajon/San Diego

2.0 star property
7.6 out of 10, Good, (1002)
"Good stay and good service "
The price is SAR 314
SAR 346 total
includes taxes & fees
13 Apr - 14 Apr
Super 8 by Wyndham El Cajon/San Diego

Best Western Plus La Mesa San Diego

2.5 star property
8.2 out of 10, Very Good, (1000)
"THE STAFF WAS OUTSTANDING! THE ROOM WAS PERFECT FOR OUR NEEDS!"
The price is SAR 388
SAR 426 total
includes taxes & fees
20 Apr - 21 Apr
Best Western Plus La Mesa San Diego

SpringHill Suites by Marriott Chula Vista Eastlake

3.5 star property
9.6 out of 10, Exceptional, (296)
"Very accommodating and especially cleanliness. Easy check ins . Breakfasts just end too early!"
The price is SAR 657
SAR 724 total
includes taxes & fees
13 Apr - 14 Apr
SpringHill Suites by Marriott Chula Vista Eastlake

Ayres Hotel San Diego South - Chula Vista

3.0 star property
9.8 out of 10, Exceptional, (1102)
"Second time staying here. Staff is very friendly and helpful."
The price is SAR 598
SAR 659 total
includes taxes & fees
20 Apr - 21 Apr
Ayres Hotel San Diego South - Chula Vista

Heritage Inn La Mesa

2.0 star property
6.4 out of 10, (1004)
"Room was clean and ready "
The price is SAR 270
SAR 298 total
includes taxes & fees
10 Apr - 11 Apr
Heritage Inn La Mesa

Lamplighter Inn & Suites at SDSU

2.5 star property
9.0 out of 10, Wonderful, (1092)
"very safe and clean"
The price is SAR 542
SAR 599 total
includes taxes & fees
10 Apr - 11 Apr
Lamplighter Inn & Suites at SDSU

Best Western Chula Vista/Otay Valley Hotel

2.5 star property
7.8 out of 10, Good, (1376)
"Very close to CBX "
The price is SAR 412
SAR 453 total
includes taxes & fees
20 Apr - 21 Apr
Best Western Chula Vista/Otay Valley Hotel

La Quinta Inn by Wyndham San Diego Chula Vista

3.0 star property
8.6 out of 10, Excellent, (1135)
"Everything was well clean and safe. "
The price is SAR 484
SAR 533 total
includes taxes & fees
13 Apr - 14 Apr
La Quinta Inn by Wyndham San Diego Chula Vista

Studio 6 Suites San Ysidro, CA -San Diego South Bay

2.5 star property
7.8 out of 10, Good, (963)
"Cercano a las outles, zona tranquila "
The price is SAR 282
SAR 317 total
includes taxes & fees
10 Apr - 11 Apr
Studio 6 Suites San Ysidro, CA -San Diego South Bay

Valli Hi Motel

2.5 star property
8.2 out of 10, Very Good, (999)
"Good place to stay. Clean, quiet, the staff are very nice and helpful. "
The price is SAR 311
SAR 350 total
includes taxes & fees
14 Apr - 15 Apr
Valli Hi Motel

Best Western Americana Inn

2.5 star property
8.8 out of 10, Excellent, (1067)
"Ok. Good"
The price is SAR 459
SAR 517 total
includes taxes & fees
15 Apr - 16 Apr
Best Western Americana Inn

Chula Vista Inn

2.5 star property
6.4 out of 10, (1003)
"Great stay as always !"
The price is SAR 321
SAR 353 total
includes taxes & fees
13 Apr - 14 Apr
Chula Vista Inn

Quality Inn San Diego South - Chula Vista

2.5 star property
7.6 out of 10, Good, (908)
"Better than most "
The price is SAR 308
SAR 339 total
includes taxes & fees
20 Apr - 21 Apr
Quality Inn San Diego South - Chula Vista

Days Inn by Wyndham Chula Vista/San Diego

2.0 star property
6.2 out of 10, (902)
"Clean room, everything was great"
The price is SAR 354
SAR 390 total
includes taxes & fees
5 May - 6 May
Days Inn by Wyndham Chula Vista/San Diego

Hotel Palmeras Chula Vista

2.0 star property
7.0 out of 10, Good, (1719)
"Nice "
The price is SAR 270
SAR 297 total
includes taxes & fees
13 Apr - 14 Apr
Hotel Palmeras Chula Vista

Hercor Hotel - Urban Boutique

3.0 star property
8.6 out of 10, Excellent, (1143)
"IMME HE QUEDADO EN ESTE HOTEL ANTES Y TODO ESTA MUY BIEN. LAS PERSONAS MUY AMABLES Y LOS CUARTOS MUY ESPACIOSOS"
The price is SAR 405
SAR 446 total
includes taxes & fees
1 May - 2 May
Hercor Hotel - Urban Boutique
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Otay Mesa
Save an average of 15% on thousands of hotels when you're signed in

Frequently asked questions

What's it like in Otay Mesa?

Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.

How many hotels will I be able to find in the Otay Mesa area?

Expedia has 5 Otay Mesa hotels and other accommodations, and one might make a good home base for venturing out into the greater San Diego area.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.

Where can I learn more about changing or cancelling my trip to Otay Mesa?

To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.

What is there to do in this San Diego neighborhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.