Find 4 Star Hotels in Otay Mesa, CA from SAR 363
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Otay Mesa 4 Star Hotels
Tonight
Tomorrow
This weekend
Next weekend
Compare Otay Mesa 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

San Diego Marriott Gaslamp Quarter
San Diego Marriott Gaslamp Quarter
8.6 out of 10, Excellent, (1330)
The price is SAR 666
SAR 751 total
includes taxes & fees
9 Mar - 10 Mar

Hyatt Regency Mission Bay Spa and Marina
Hyatt Regency Mission Bay Spa and Marina
8.6 out of 10, Excellent, (1447)
The price is SAR 634
SAR 879 total
includes taxes & fees
9 Mar - 10 Mar

Sheraton San Diego Resort
Sheraton San Diego Resort
8.0 out of 10, Very Good, (2562)
The price is SAR 539
SAR 759 total
includes taxes & fees
7 Mar - 8 Mar

Omni San Diego Hotel
Omni San Diego Hotel
9.0 out of 10, Wonderful, (1861)
The price is SAR 777
SAR 1,041 total
includes taxes & fees
21 Mar - 22 Mar

Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
9.0 out of 10, Wonderful, (2792)
The price is SAR 709
SAR 977 total
includes taxes & fees
8 Mar - 9 Mar

Hotel Indigo San Diego-Gaslamp Quarter by IHG
Hotel Indigo San Diego-Gaslamp Quarter by IHG
8.6 out of 10, Excellent, (1006)
The price is SAR 784
SAR 1,019 total
includes taxes & fees
2 Mar - 3 Mar

Loews Coronado Bay Resort
Loews Coronado Bay Resort
8.8 out of 10, Excellent, (1004)
The price is SAR 784
SAR 1,041 total
includes taxes & fees
2 Mar - 3 Mar

Wyndham San Diego Bayside
Wyndham San Diego Bayside
8.2 out of 10, Very Good, (5608)
The price is SAR 571
SAR 643 total
includes taxes & fees
7 Mar - 8 Mar
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Otay Mesa.

Pendry San Diego
550 J Street, San Diego, CA
The price is SAR 1,031 per night from Mar 14 to Mar 15
SAR 1,031
SAR 1,354 total
includes taxes & fees
14 Mar - 15 Mar
9.2/10 Wonderful! (1,001 reviews)
Still don't see what you're looking for?
See all properties in Otay Mesa.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent reviews of Otay Mesa hotels
Recent reviews of Otay Mesa hotels

Marriott Marquis San Diego Marina
5/5 Excellent
Cool spot for a little get away
"Great stay we almost extended our stay but we had to go"
A verified traveler stayed at Marriott Marquis San Diego Marina
Posted 1 day ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Otay Mesa Hotels by Star Rating
Stay near popular Otay Mesa attractions
- Hotels near San Diego Zoo
- Hotels near San Diego Convention Center
- Hotels near Mission Bay
- Hotels near San Ysidro Border Crossing
- Hotels near Balboa Park
- Hotels near Mission Beach
- Hotels near Petco Park
- Hotels near San Diego State University
- Hotels near Hotel Circle
- Hotels near Marine Corps Recruit Depot
- Hotels near Naval Base San Diego
- Hotels near USS Midway Museum
- Hotels near Hotel del Coronado
- Hotels near Port of San Diego
- Hotels near Coronado Beach
- Hotels near University of San Diego
- Hotels near B Street Cruise Ship Terminal
- Hotels near Mission Beach Boardwalk
- Hotels near Seaport Village
- Hotels near Las Americas Premium Outlets
More Hotel Options in Otay Mesa
- Beach Hotels in Otay Mesa
- Business Hotels in Otay Mesa
- Casinos in Otay Mesa
- Cheap Hotels in Otay Mesa
- Family Hotels in Otay Mesa
- Golf Hotels in Otay Mesa
- Historic Hotels in Otay Mesa
- Hotels with Free Parking in Otay Mesa
- Hotels with Hot Tubs in Otay Mesa
- Hotels with WiFi in Otay Mesa
- Hotels with a Pool in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
- Luxury Hotels in Otay Mesa
- Resorts & Hotels with Spas in Otay Mesa
- Shopping Hotels in Otay Mesa
- Winery Hotels in Otay Mesa
Explore more hotels
- Sheraton San Diego Resort
- Kings Inn San Diego
- Marriott Marquis San Diego Marina
- Lafayette Hotel & Club
- Paradise Point Resort & Spa
- Loews Coronado Bay Resort
- San Diego Mission Bay Resort
- Legacy Resort Hotel & Spa
- Manchester Grand Hyatt San Diego
- Best Western Plus Marina Gateway Hotel
- The Horton Grand, Downtown/Gaslamp Quarter
- Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
- Days Inn by Wyndham San Diego Hotel Circle
- Pendry San Diego
- San Diego Marriott Gaslamp Quarter
- Hilton San Diego Mission Valley
- The Sofia Hotel
- Alma San Diego Downtown, a Tribute Portfolio Hotel
- AC Hotel by Marriott San Diego Downtown Gaslamp Quarter
- Bahia Resort Hotel