Find Resorts & Hotels with Spas in Otay Mesa, CA
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Otay Mesa Resorts & Hotels with Spas
Tonight
Tomorrow
This weekend
Next weekend
Compare Otay Mesa Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay Mesa
7.2 out of 10, Good, (1155)
The price is SAR 368
SAR 414 total
includes taxes & fees
13 Apr - 14 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find out more about Otay Mesa
Find out more about Otay Mesa
Recent reviews of Otay Mesa hotels
Recent reviews of Otay Mesa hotels

Loews Coronado Bay Resort
5/5 Excellent
"Nice places , pool area was great , exercise room was excellent , the girls at the spa were friendly and very helpful,restaurant was great, "
A verified traveler stayed at Loews Coronado Bay Resort
Posted 15 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Find More Hotels near Otay Mesa
- Resorts & Hotels with Spas in Downtown San Diego
- Resorts & Hotels with Spas in Pacific Beach
- Resorts & Hotels with Spas in Gaslamp Quarter
- Resorts & Hotels with Spas in Ocean Beach
- Resorts & Hotels with Spas in Point Loma
- Resorts & Hotels with Spas in Mission Valley
- Resorts & Hotels with Spas in Little Italy
More Hotel Options in Otay Mesa
- Beach Hotels in Otay Mesa
- Business Hotels in Otay Mesa
- Casinos in Otay Mesa
- Cheap Hotels in Otay Mesa
- Family Hotels in Otay Mesa
- Golf Hotels in Otay Mesa
- Historic Hotels in Otay Mesa
- Hotels with Free Parking in Otay Mesa
- Hotels with Hot Tubs in Otay Mesa
- Hotels with WiFi in Otay Mesa
- Hotels with a Pool in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
- Luxury Hotels in Otay Mesa
- Shopping Hotels in Otay Mesa
- Winery Hotels in Otay Mesa
More Accommodation Types in Otay Mesa
- Vacation Homes in San Diego
- Apartments in San Diego
- Condo Rentals in San Diego
- Cottages in San Diego
- Villas in San Diego
- Guest Houses in San Diego
- Aparthotels in San Diego
- Resorts in San Diego
- Motels in San Diego
- Hostels in San Diego
- B&B in San Diego
- Cabin Rentals in San Diego
- RV Parks in San Diego
- Inns in San Diego
- Houseboats in San Diego
Hotels near popular San Diego Attractions
Otay Mesa Hotels by Star Rating
Explore more hotels
- Handlery Hotel
- Comfort Inn Sea World Area
- Hilton San Diego Mission Valley
- Sheraton San Diego Resort
- Sheraton Mission Valley San Diego Hotel
- The Little Italy Hotel Downtown San Diego
- The Dextro Hotel, BW Premier Collection
- Lafayette Hotel & Club
- Wyndham Garden San Diego Near SeaWorld
- Bahia Resort Hotel
- Bay Club Hotel & Marina
- Kings Inn San Diego
- Hard Rock Hotel San Diego
- DoubleTree by Hilton Hotel San Diego - Mission Valley
- Palihotel San Diego Gaslamp Quarter
- Manchester Grand Hyatt San Diego
- Embassy Suites by Hilton San Diego Bay Downtown
- The Guild Hotel, San Diego, A Tribute Portfolio Hotel by Marriott
- Alma San Diego Downtown, a Tribute Portfolio Hotel
- Omni San Diego Hotel