Find 5 Star Hotels in Otay Mesa, CA from SAR 571
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Otay Mesa 5 Star Hotels
Tonight
Tomorrow
This weekend
Next weekend
Compare Otay Mesa 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Pendry San Diego
Pendry San Diego
9.2 out of 10, Wonderful, (1002)
The price is SAR 1,032
SAR 1,387 total
includes taxes & fees
22 May - 23 May

The US Grant, a Luxury Collection Hotel, San Diego
The US Grant, a Luxury Collection Hotel, San Diego
9.0 out of 10, Wonderful, (1005)
The price is SAR 1,084
SAR 1,257 total
includes taxes & fees
11 May - 12 May

Beach Village at The Del, LXR Hotels & Resorts
Beach Village at The Del, LXR Hotels & Resorts
9.0 out of 10, Wonderful, (99)
The price is SAR 2,971
SAR 3,461 total
includes taxes & fees
12 May - 13 May
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Otay Mesa.

Wyndham San Diego Bayside
1355 N Harbor Drive, San Diego, CA
The price is SAR 571 per night from May 11 to May 12
SAR 571
SAR 662 total
includes taxes & fees
11 May - 12 May
8.2/10 Very Good! (5,682 reviews)
Still don't see what you're looking for?
See all properties in Otay Mesa.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Otay Mesa Hotels by Star Rating
Stay near popular Otay Mesa attractions
- Hotels near Cross Border Xpress
- Hotels near San Diego Zoo
- Hotels near San Diego Convention Center
- Hotels near Mission Bay
- Hotels near Petco Park
- Hotels near San Ysidro Border Crossing
- Hotels near Mission Beach
- Hotels near Balboa Park
- Hotels near San Diego State University
- Hotels near Hotel Circle
- Hotels near Naval Base San Diego
- Hotels near Coronado Beach
- Hotels near Marine Corps Recruit Depot
- Hotels near University of San Diego
- Hotels near USS Midway Museum
- Hotels near Port of San Diego
- Hotels near Seaport Village
- Hotels near Mission Beach Boardwalk
- Hotels near Hotel del Coronado
- Hotels near Naval Base Coronado
More Hotel Options in Otay Mesa
- Beach Hotels in Otay Mesa
- Business Hotels in Otay Mesa
- Casinos in Otay Mesa
- Cheap Hotels in Otay Mesa
- Family Hotels in Otay Mesa
- Golf Hotels in Otay Mesa
- Historic Hotels in Otay Mesa
- Hotels with Free Parking in Otay Mesa
- Hotels with Hot Tubs in Otay Mesa
- Hotels with WiFi in Otay Mesa
- Hotels with a Pool in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
- Luxury Hotels in Otay Mesa
- Resorts & Hotels with Spas in Otay Mesa
- Shopping Hotels in Otay Mesa
- Winery Hotels in Otay Mesa
Explore more hotels
- Bahia Resort Hotel
- Wyndham Garden San Diego Near SeaWorld
- Best Western Seven Seas
- DoubleTree by Hilton Hotel San Diego - Mission Valley
- Loews Coronado Bay Resort
- Palihotel San Diego Gaslamp Quarter
- Comfort Inn Sea World Area
- Days Inn by Wyndham San Diego Hotel Circle
- The Guild Hotel, San Diego, A Tribute Portfolio Hotel by Marriott
- Legacy Resort Hotel & Spa
- Hyatt Regency Mission Bay Spa and Marina
- Sheraton San Diego Resort
- Embassy Suites by Hilton San Diego Bay Downtown
- Marriott Marquis San Diego Marina
- Manchester Grand Hyatt San Diego
- Hard Rock Hotel San Diego
- Pendry San Diego
- The Sofia Hotel
- The Little Italy Hotel Downtown San Diego
- The Westin San Diego Bayview