Photo by Michele Butts
Find Business Hotels in La Mesa, CA
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on La Mesa Business Hotels
Tonight
Tomorrow
This weekend
Next weekend
Compare La Mesa Business Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Best Western Plus La Mesa San Diego
Best Western Plus La Mesa San Diego
8.2 out of 10, Very Good, (1001)
The price is SAR 443
SAR 487 total
includes taxes & fees
20 Apr - 21 Apr

Holiday Inn Express La Mesa Near SDSU by IHG
Holiday Inn Express La Mesa Near SDSU by IHG
8.4 out of 10, Very Good, (270)
The price is SAR 475
SAR 523 total
includes taxes & fees
23 Mar - 24 Mar

Motel 6 La Mesa, CA
Motel 6 La Mesa, CA
7.2 out of 10, Good, (1002)
The price is SAR 364
SAR 400 total
includes taxes & fees
30 Mar - 31 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find out more about La Mesa
Find out more about La Mesa
Recent reviews of La Mesa hotels
Recent reviews of La Mesa hotels

Paradise Point Resort & Spa
5/5 Excellent
"The resort is gorgeous, making any walk around so pleasant! Their yoga class with Ishmael was one of the best yoga classes i have ever experienced. Highly recommend! "
A verified traveler stayed at Paradise Point Resort & Spa
Posted 20 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Find More Hotels near La Mesa
More Hotel Options in La Mesa
- Adults Only Resorts & Hotels in La Mesa
- Adventure Hotels in La Mesa
- Beach Hotels in La Mesa
- Cheap Hotels in La Mesa
- Family Hotels in La Mesa
- Golf Hotels in La Mesa
- Historic Hotels in La Mesa
- Hotel Wedding Venues in La Mesa
- Hotel with a Concierge in La Mesa
- Hotels with Bars in La Mesa
- Hotels with Free Parking in La Mesa
- Hotels with Hot Tubs in La Mesa
- Hotels with WiFi in La Mesa
- Hotels with a Pool in La Mesa
- Hotels with smoking rooms in La Mesa
- Luxury Hotels in La Mesa
- Pet-friendly Hotels in La Mesa
- Resorts & Hotels with Spas in La Mesa
- Romantic Hotels in La Mesa
- Shopping Hotels in La Mesa
More Accommodation Types in La Mesa
- Vacation Homes in California
- Condo Rentals in California
- Apartments in California
- Cabin Rentals in California
- Cottages in California
- Villas in California
- Motels in California
- Resorts in California
- Guest Houses in California
- B&B in California
- Aparthotels in California
- Chalets in California
- RV Parks in California
- Lodges in California
- Hostels in California
- Inns in California
- Houseboats in California
- Condo Resorts in California
- Holiday Park Resorts in California
- Residences in California
- Ranches in California
- Country Houses in California
- Capsule Hotels in California
- Safari Tentalow in California
- Treehouses in California
Hotels near popular La Mesa Attractions
- Hotels near Mount Helix Park
- Hotels near Computer Museum of America
- Hotels near San Diego Zoo
- Hotels near San Diego Convention Center
- Hotels near Mission Bay
- Hotels near San Ysidro Border Crossing
- Hotels near Balboa Park
- Hotels near Mission Beach
- Hotels near Petco Park
- Hotels near San Diego State University
La Mesa Hotels by Star Rating
Explore more hotels
- Best Western Seven Seas
- Omni San Diego Hotel
- Handlery Hotel
- Legacy Resort Hotel & Spa
- Paradise Point Resort & Spa
- Kings Inn San Diego
- Hard Rock Hotel San Diego
- Sheraton Mission Valley San Diego Hotel
- Lafayette Hotel & Club
- Best Western Premier Hotel Del Mar
- Loews Coronado Bay Resort
- Hyatt Regency Mission Bay Spa and Marina
- Marriott Marquis San Diego Marina
- Embassy Suites by Hilton San Diego La Jolla
- Hilton San Diego Mission Valley
- DoubleTree by Hilton San Diego - Del Mar
- Alma San Diego Downtown, a Tribute Portfolio Hotel
- Manchester Grand Hyatt San Diego
- Comfort Inn San Diego Airport At The Harbor
- Bahia Resort Hotel