Photo by Linda Cronan

Find hotels in Medical Center District, San Antonio from SAR 267

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Discover 4,215 Medical Center District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Riverwalk Plaza
Lobby

Riverwalk Plaza

4.0 star property
8.2 out of 10, Very Good, (4511)
"Great hotel!!! Very clean and the staff very friendly! Loved!"
The price is SAR 348
SAR 411 total
includes taxes & fees
13 Jan - 14 Jan
Riverwalk Plaza
Drury Plaza Hotel San Antonio Riverwalk
Exterior

Drury Plaza Hotel San Antonio Riverwalk

3.0 star property
9.4 out of 10, Exceptional, (3025)
"We loved the stay but I think that when we reserve should have a note that the charge for parking. "
The price is SAR 450
SAR 532 total
includes taxes & fees
22 Jan - 23 Jan
Drury Plaza Hotel San Antonio Riverwalk
Menger Hotel
Exterior

Menger Hotel

3.5 star property
9.0 out of 10, Wonderful, (3156)
"The Menger Hotel I think is one of the best locations in San Antonio to stay. You have got everything you need right around the corner. It is safe and the food and entertainment never ends. Staff is friendly and is great for information. Beautiful historical Hotel. Try to stay at least 2 times a year."
The price is SAR 409
SAR 490 total
includes taxes & fees
12 Jan - 13 Jan
Menger Hotel
Omni La Mansion del Rio
Terrace/patio

Omni La Mansion del Rio

4.0 star property
9.4 out of 10, Exceptional, (2422)
"Nice hotel in old traditional building, on the riverwalk at the happening area, walking distance to attractions, restaurants, centrally located, nice breakfast area, pool. Parking garage across the street, easy to park. The room was spacious; would recommend a river view room with a private balcony."
The price is SAR 667
SAR 800 total
includes taxes & fees
12 Jan - 13 Jan
Omni La Mansion del Rio
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Pool

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3.0 star property
7.8 out of 10, Good, (3345)
"Stayed a week and was pleasantly surprised. It was quiet, the breakfast was amazing and was walkable to all of Riverwalks havings. Also having laundry available was a plus. "
The price is SAR 267
SAR 537 total
includes taxes & fees
20 Jan - 21 Jan
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Hotel Contessa
Living area

Hotel Contessa

4.0 star property
9.0 out of 10, Wonderful, (2998)
"Beautiful hotel. Super clean. Breakfast was delicious. The pool was warm in January which was nice. We appreciated the safety measures including key access only to the elevators. Every single staff member greeted us or spoke kindly. We will be back. It was great being steps away from the Riverwalk. "
The price is SAR 539
SAR 695 total
includes taxes & fees
20 Jan - 21 Jan
Hotel Contessa
Hyatt Regency San Antonio Riverwalk
Pool

Hyatt Regency San Antonio Riverwalk

4.0 star property
9.0 out of 10, Wonderful, (1668)
"The hotel was at max capacity so grabbing an elevator was not easy. BUT--that was to be expected. We enjoyed our stay!!"
The price is SAR 747
SAR 1,015 total
includes taxes & fees
12 Jan - 13 Jan
Hyatt Regency San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Downtown
Exterior

La Quinta Inn & Suites by Wyndham San Antonio Downtown

2.5 star property
8.8 out of 10, Excellent, (2596)
"Very good at q All"
The price is SAR 339
SAR 401 total
includes taxes & fees
27 Jan - 28 Jan
La Quinta Inn & Suites by Wyndham San Antonio Downtown
Hotel Valencia Riverwalk
Exterior

Hotel Valencia Riverwalk

4.5 star property
9.4 out of 10, Exceptional, (1851)
"Beautiful hotel very professional and accommodating staff."
The price is SAR 542
SAR 709 total
includes taxes & fees
15 Jan - 16 Jan
Hotel Valencia Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Front of property

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

2.5 star property
8.6 out of 10, Excellent, (2160)
"it was very clean staff was great i really enjoyed my stay"
The price is SAR 333
SAR 394 total
includes taxes & fees
12 Jan - 13 Jan
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Hyatt Place San Antonio - Riverwalk
Room

Hyatt Place San Antonio - Riverwalk

3.0 star property
8.8 out of 10, Excellent, (1052)
"Very convinient. "
The price is SAR 462
SAR 546 total
includes taxes & fees
18 Jan - 19 Jan
Hyatt Place San Antonio - Riverwalk
Crockett Hotel
Reception

Crockett Hotel

3.0 star property
8.8 out of 10, Excellent, (2239)
"The concierge was very helpful and informative . My family of 4 has a great stay it was walking distance to all the sights the kids wanted to see"
The price is SAR 409
SAR 484 total
includes taxes & fees
12 Jan - 13 Jan
Crockett Hotel
Canopy by Hilton San Antonio Riverwalk
Exterior

Canopy by Hilton San Antonio Riverwalk

4.0 star property
9.2 out of 10, Wonderful, (1409)
"Wounderful place to stay"
The price is SAR 727
SAR 874 total
includes taxes & fees
16 Jan - 17 Jan
Canopy by Hilton San Antonio Riverwalk
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
Exterior

Holiday Inn San Antonio - Riverwalk, an IHG Hotel

3.0 star property
8.4 out of 10, Very Good, (1004)
"The breakfast was very good "
The price is SAR 349
SAR 413 total
includes taxes & fees
19 Jan - 20 Jan
Holiday Inn San Antonio - Riverwalk, an IHG Hotel
InterContinental San Antonio Riverwalk, an IHG Hotel
Exterior

InterContinental San Antonio Riverwalk, an IHG Hotel

4.5 star property
9.4 out of 10, Exceptional, (229)
"Excellent from rooms to service"
The price is SAR 582
SAR 816 total
includes taxes & fees
14 Jan - 15 Jan
InterContinental San Antonio Riverwalk, an IHG Hotel
Grand Hyatt San Antonio River Walk
Pool

Grand Hyatt San Antonio River Walk

4.0 star property
9.0 out of 10, Wonderful, (1084)
"hotel was very nice and within walking distance of many attractions and restaurants"
The price is SAR 668
SAR 801 total
includes taxes & fees
12 Jan - 13 Jan
Grand Hyatt San Antonio River Walk
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Exterior

Sonesta ES Suites San Antonio Downtown Alamo Plaza

3.0 star property
8.2 out of 10, Very Good, (1313)
"Friendly staff! Easy checkin"
The price is SAR 285
SAR 337 total
includes taxes & fees
15 Jan - 16 Jan
Sonesta ES Suites San Antonio Downtown Alamo Plaza
The St. Anthony, A Luxury Collection Hotel, San Antonio
Room

The St. Anthony, A Luxury Collection Hotel, San Antonio

4.5 star property
8.8 out of 10, Excellent, (1001)
"Amazing Hotel!"
The price is SAR 807
SAR 954 total
includes taxes & fees
17 Jan - 18 Jan
The St. Anthony, A Luxury Collection Hotel, San Antonio
The Maverick, powered by Placemakr - River Walk
Room

The Maverick, powered by Placemakr - River Walk

4.0 star property
8.6 out of 10, Excellent, (499)
"The staff and location was the best, the building was old, but clean and nice. You had to sign in or sign up for various apps in order to watch TV, i.e. Netflix or Freevee or Pluto. It would have been nice to have double pane windows as the outside noise was a little loud throughout the night. "
The price is SAR 389
SAR 454 total
includes taxes & fees
27 Jan - 28 Jan
The Maverick, powered by Placemakr - River Walk
AC Hotel by Marriott San Antonio Riverwalk
Exterior

AC Hotel by Marriott San Antonio Riverwalk

4.0 star property
8.8 out of 10, Excellent, (610)
"Great facility and location "
The price is SAR 428
SAR 506 total
includes taxes & fees
14 Jan - 15 Jan
AC Hotel by Marriott San Antonio Riverwalk
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What is Medical Center District like?

Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.

What's a favorite place to stay in Medical Center District?

Based on Expedia customer reviews, Drury Inn & Suites San Antonio Northwest Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and an indoor pool. Other favorite options in the area include SpringHill Suites by Marriott San Antonio Medical Center/NW and Fairfield Inn & Suites by Marriott San Antonio Medical Center.

How many hotels will I be able to find in Medical Center District?

Expedia has 126 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.

Where can I learn more about changing or cancelling my trip to Medical Center District?

For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.

What can I see and do in this San Antonio neighborhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and The San Antonio Art Institute. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.