Photo by Linda Cronan
Find hotels in Medical Center District, San Antonio from SAR 152
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Go beyond your typical stay in Medical Center District
Pet friendly
Check prices for these dates
Tonight
Tomorrow
This weekend
Next weekend
Discover 4,252 Medical Center District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Drury Inn & Suites San Antonio Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
9.2 out of 10, Wonderful, (1223)
The price is SAR 375
SAR 443 total
includes taxes & fees
8 May - 9 May

San Antonio Marriott Northwest Medical Center
San Antonio Marriott Northwest Medical Center
8.4 out of 10, Very Good, (1005)
The price is SAR 357
SAR 424 total
includes taxes & fees
2 Jun - 3 Jun

Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
8.6 out of 10, Excellent, (1004)
The price is SAR 368
SAR 434 total
includes taxes & fees
11 May - 12 May

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
8.6 out of 10, Excellent, (2476)
The price is SAR 372
SAR 440 total
includes taxes & fees
6 May - 7 May

Fairfield Inn & Suites by Marriott San Antonio Medical Center
Fairfield Inn & Suites by Marriott San Antonio Medical Center
9.0 out of 10, Wonderful, (838)
The price is SAR 345
SAR 403 total
includes taxes & fees
18 May - 19 May

SpringHill Suites by Marriott San Antonio Medical Center/NW
SpringHill Suites by Marriott San Antonio Medical Center/NW
8.8 out of 10, Excellent, (1002)
The price is SAR 409
SAR 483 total
includes taxes & fees
11 May - 12 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Where to stay in Medical Center District
Where to stay in Medical Center District
Hotels in top San Antonio neighborhoods Learn more about Medical Center District

Downtown San Antonio
4 out of top 10 points of interest in this area
4/5(9,525 area reviews)
Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.
Recent reviews of Medical Center District hotels
Recent reviews of Medical Center District hotels

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
5/5 Excellent
Fun Fun Fun at the Hyatt/Wild Oak Ranch!
"Great fun! We loved the lazy river, the water slide and the Antlers Lodge restaurant across the street at The Hyatt Spa. "
A verified traveler stayed at Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Posted 7 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top San Antonio neighborhoods
Hotels near popular San Antonio Attractions
- Hotels near USAA Corporate Office Headquarters
- Hotels near South Texas Medical Center
- Hotels near University of Texas Health and Science Center at San Antonio
- Hotels near CHRISTUS Santa Rosa Hospital - Medical Center
- Hotels near Oak Hills Country Club
- Hotels near The San Antonio Art Institute
- Hotels near River Walk
More Accommodation Types in
- Vacation Homes in San Antonio
- Apartments in San Antonio
- Cottages in San Antonio
- Condo Rentals in San Antonio
- Motels in San Antonio
- Villas in San Antonio
- Guest Houses in San Antonio
- Resorts in San Antonio
- B&B in San Antonio
- Aparthotels in San Antonio
- RV Parks in San Antonio
- Inns in San Antonio
- Lodges in San Antonio
- Residences in San Antonio
- Holiday Park Resorts in San Antonio
- Ranches in San Antonio
Hotels Close to Nearby Airports
Medical Center District Hotels by Star Rating
Explore more hotels
- Hotel Contessa
- Hyatt Vacation Club at Wild Oak Ranch, San Antonio
- La Cantera Resort & Spa
- Days Inn by Wyndham San Antonio Alamo/Riverwalk
- Omni La Mansion del Rio
- Grand Hyatt San Antonio River Walk
- Sonesta ES Suites San Antonio Downtown Alamo Plaza
- Hyatt Regency Hill Country Resort & Spa
- JW Marriott San Antonio Hill Country Resort & Spa
- La Quinta Inn & Suites by Wyndham San Antonio Airport
- The Westin Riverwalk, San Antonio
- Hilton San Antonio Hill Country