Photo by Linda Cronan

Find hotels in Medical Center District, San Antonio from SAR 251

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Discover 4,157 Medical Center District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Riverwalk Plaza
Lobby

Riverwalk Plaza

4.0 star property
8.2 out of 10, Very Good, (4300)
"good property - older and layout is weird but it was a fine stay"
The price is SAR 368
SAR 435 total
includes taxes & fees
15 Dec - 16 Dec
Riverwalk Plaza
Menger Hotel
Outdoor pool

Menger Hotel

3.5 star property
9.0 out of 10, Wonderful, (3099)
"Awesome. Even with all of the construction!"
The price is SAR 492
SAR 571 total
includes taxes & fees
16 Dec - 17 Dec
Menger Hotel
Drury Plaza Hotel San Antonio Riverwalk
Exterior

Drury Plaza Hotel San Antonio Riverwalk

3.0 star property
9.4 out of 10, Exceptional, (2939)
"The Hotel was an amazing experience overall. It neighbors the historic Riverwalk and is literally an 8 minute walk to the Alamo and an 8-9 minute walk (if you choose to) to the H.E.B. market. Staff is excellent and very friendly. "
The price is SAR 451
SAR 533 total
includes taxes & fees
27 Nov - 28 Nov
Drury Plaza Hotel San Antonio Riverwalk
Omni La Mansion del Rio
Terrace/patio

Omni La Mansion del Rio

4.0 star property
9.2 out of 10, Wonderful, (2374)
"Beautiful property"
The price is SAR 699
SAR 817 total
includes taxes & fees
25 Nov - 26 Nov
Omni La Mansion del Rio
Hotel Valencia Riverwalk
Exterior

Hotel Valencia Riverwalk

4.5 star property
9.4 out of 10, Exceptional, (1870)
"We loved that it was on the RiverWalk and within walking distance of most things we wanted to see. The staff was excellent and there really isn’t anything we could point out that we didn’t like. All in all it was a pleasant experience!"
The price is SAR 595
SAR 746 total
includes taxes & fees
22 Dec - 23 Dec
Hotel Valencia Riverwalk
Hyatt Place San Antonio - Riverwalk
Room

Hyatt Place San Antonio - Riverwalk

3.0 star property
8.8 out of 10, Excellent, (1060)
"Excellent!"
The price is SAR 456
SAR 526 total
includes taxes & fees
25 Nov - 26 Nov
Hyatt Place San Antonio - Riverwalk
Canopy by Hilton San Antonio Riverwalk
Exterior

Canopy by Hilton San Antonio Riverwalk

4.0 star property
9.2 out of 10, Wonderful, (1414)
"A beautiful hotel near the River Walk... Just far enough away to be quiet but close enough to all the restaurants, bars and entertainment that you can walk. Loved it!"
The price is SAR 696
SAR 807 total
includes taxes & fees
15 Dec - 16 Dec
Canopy by Hilton San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Downtown
Exterior

La Quinta Inn & Suites by Wyndham San Antonio Downtown

2.5 star property
8.8 out of 10, Excellent, (2535)
"Staff was extremely pleasant and room was nice "
The price is SAR 301
SAR 347 total
includes taxes & fees
22 Dec - 23 Dec
La Quinta Inn & Suites by Wyndham San Antonio Downtown
Hyatt Regency San Antonio Riverwalk
Pool

Hyatt Regency San Antonio Riverwalk

4.0 star property
9.0 out of 10, Wonderful, (1666)
"Close to where I needed to be."
The price is SAR 628
SAR 856 total
includes taxes & fees
26 Nov - 27 Nov
Hyatt Regency San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Pool

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3.0 star property
7.6 out of 10, Good, (3201)
"Enjoyed the location."
The price is SAR 301
SAR 346 total
includes taxes & fees
25 Nov - 26 Nov
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
InterContinental San Antonio Riverwalk, an IHG Hotel
Exterior

InterContinental San Antonio Riverwalk, an IHG Hotel

4.5 star property
9.8 out of 10, Exceptional, (157)
"Great staff"
The price is SAR 530
SAR 736 total
includes taxes & fees
18 Dec - 19 Dec
InterContinental San Antonio Riverwalk, an IHG Hotel
The Maverick, powered by Placemakr - River Walk
Room

The Maverick, powered by Placemakr - River Walk

4.0 star property
8.6 out of 10, Excellent, (419)
"The historic feel was amazing!! "
The price is SAR 410
SAR 466 total
includes taxes & fees
15 Dec - 16 Dec
The Maverick, powered by Placemakr - River Walk
Crockett Hotel
Pool

Crockett Hotel

3.0 star property
8.8 out of 10, Excellent, (2136)
"The staff members are extremely nice. We dined at the Crockett Tavern and we loved the atmosphere."
The price is SAR 393
SAR 450 total
includes taxes & fees
15 Dec - 16 Dec
Crockett Hotel
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Front of property

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

2.5 star property
8.6 out of 10, Excellent, (2142)
"I needed to stay overnight for a hospital visit - it was very convenient to where I needed to be, the staff was kind and courteous, and the room was perfect. Will be back to stay again."
The price is SAR 251
SAR 297 total
includes taxes & fees
4 Dec - 5 Dec
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Homewood Suites by Hilton San Antonio Riverwalk/Downtown
Exterior

Homewood Suites by Hilton San Antonio Riverwalk/Downtown

3.0 star property
8.4 out of 10, Very Good, (1006)
"Very clean and nicely furnished. Plenty of room. Fantastic location! Will definitely stay here again."
The price is SAR 412
SAR 482 total
includes taxes & fees
15 Dec - 16 Dec
Homewood Suites by Hilton San Antonio Riverwalk/Downtown
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Exterior

Sonesta ES Suites San Antonio Downtown Alamo Plaza

3.0 star property
8.2 out of 10, Very Good, (1371)
"Close to eveything"
The price is SAR 327
SAR 376 total
includes taxes & fees
1 Dec - 2 Dec
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Grand Hyatt San Antonio River Walk
Pool

Grand Hyatt San Antonio River Walk

4.0 star property
9.0 out of 10, Wonderful, (1080)
"Ok"
The price is SAR 598
SAR 810 total
includes taxes & fees
26 Nov - 27 Nov
Grand Hyatt San Antonio River Walk
La Quinta Inn & Suites by Wyndham San Antonio Airport
Exterior

La Quinta Inn & Suites by Wyndham San Antonio Airport

2.5 star property
7.8 out of 10, Good, (2762)
"Ok location"
The price is SAR 282
SAR 334 total
includes taxes & fees
2 Dec - 3 Dec
La Quinta Inn & Suites by Wyndham San Antonio Airport
Hotel Gibbs Downtown Riverwalk
Front of property

Hotel Gibbs Downtown Riverwalk

4.5 star property
9.0 out of 10, Wonderful, (3223)
"Great stay "
The price is SAR 392
SAR 457 total
includes taxes & fees
24 Nov - 25 Nov
Hotel Gibbs Downtown Riverwalk
AC Hotel by Marriott San Antonio Riverwalk
Restaurant

AC Hotel by Marriott San Antonio Riverwalk

4.0 star property
8.8 out of 10, Excellent, (532)
"Property was beautiful. Staff was nice. Rooms were clean. Good resturants and bars inside the hotel and in the area. Breakfast was good when ordering from the menu. The only thing that was disappointing was I booked a King bed city veiw and they gave me a room with 2 queen beds and I didn't sleep well at all due to my feet were hanging off the bed. Make sure you call and checkbto make sure they give you the correct room."
The price is SAR 443
SAR 510 total
includes taxes & fees
25 Nov - 26 Nov
AC Hotel by Marriott San Antonio Riverwalk
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What is Medical Center District like?

Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.

What's a favorite place to stay in Medical Center District?

Based on Expedia customer reviews, Drury Inn & Suites San Antonio Northwest Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and an indoor pool. Other favorite options in the area include SpringHill Suites by Marriott San Antonio Medical Center/NW and Fairfield Inn & Suites by Marriott San Antonio Medical Center.

How many hotels will I be able to find in Medical Center District?

Expedia has 119 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.

Where can I learn more about changing or cancelling my trip to Medical Center District?

For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.

What can I see and do in this San Antonio neighborhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and The San Antonio Art Institute. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.