Photo by Linda Cronan
Find 5 Star Hotels in Medical Center District, TX from SAR 409
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Medical Center District 5 Star Hotels
Tonight
Tomorrow
This weekend
Next weekend
Compare Medical Center District 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Thompson San Antonio - Riverwalk, by Hyatt
Thompson San Antonio - Riverwalk, by Hyatt
9.0 out of 10, Wonderful, (707)
The price is SAR 794
SAR 1,067 total
includes taxes & fees
13 Apr - 14 Apr

The Luxury Suites at Arrive Eilan
The Luxury Suites at Arrive Eilan
7.4 out of 10, Good, (129)
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Medical Center District.

Riverwalk Plaza
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
The price is SAR 409 per night from Mar 30 to Mar 31
SAR 409
SAR 483 total
includes taxes & fees
30 Mar - 31 Mar
8/10 Very Good! (4,945 reviews)
Still don't see what you're looking for?
See all properties in Medical Center District.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Medical Center District Hotels by Star Rating
Hotels in Medical Center District Neighborhoods
Stay near popular Medical Center District attractions
- Hotels near USAA Corporate Office Headquarters
- Hotels near South Texas Medical Center
- Hotels near University of Texas Health and Science Center at San Antonio
- Hotels near CHRISTUS Santa Rosa Hospital - Medical Center
- Hotels near Oak Hills Country Club
- Hotels near The San Antonio Art Institute
- Hotels near Six Flags Fiesta Texas
- Hotels near Lackland Air Force Base
- Hotels near River Walk
- Hotels near Alamo
- Hotels near San Antonio River
- Hotels near Henry B. González Convention Center
- Hotels near San Antonio Zoo and Aquarium
- Hotels near Alamodome
- Hotels near The Shops of La Cantera
- Hotels near Frost Bank Center
Explore more hotels
- Sonesta ES Suites San Antonio Downtown Alamo Plaza
- Spark By Hilton San Antonio Northwest near Six Flags
- La Quinta Inn & Suites By Wyndham San Antonio At The Rim
- Hyatt Regency San Antonio Riverwalk
- Canopy by Hilton San Antonio Riverwalk
- Hyatt Regency Hill Country Resort & Spa
- La Quinta Inn & Suites by Wyndham San Antonio Downtown
- Hyatt Vacation Club at Wild Oak Ranch, San Antonio
- The Westin Riverwalk, San Antonio
- Hotel Valencia Riverwalk
- Omni La Mansion del Rio
- Red Roof Inn PLUS+ San Antonio Downtown - Riverwalk
- Element San Antonio Riverwalk
- InterContinental San Antonio Riverwalk by IHG
- JW Marriott San Antonio Hill Country Resort & Spa
- Holiday Inn San Antonio - Riverwalk by IHG
- Hyatt Place San Antonio - Riverwalk
- Drury Plaza Hotel San Antonio Airport
- Thompson San Antonio - Riverwalk, by Hyatt
- La Quinta Inn & Suites by Wyndham San Antonio Airport