Find Resorts & Hotels with Spas in Southeast Missouri, MO
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Compare Southeast Missouri Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
9.4 out of 10, Exceptional, (1003)
The price is SAR 321
SAR 369 total
includes taxes & fees
2 Apr - 3 Apr

Drury Inn & Suites Hayti Caruthersville
Drury Inn & Suites Hayti Caruthersville
9.4 out of 10, Exceptional, (1000)
The price is SAR 383
SAR 436 total
includes taxes & fees
6 Apr - 7 Apr

Super 8 by Wyndham Perryville
Super 8 by Wyndham Perryville
8.4 out of 10, Very Good, (835)
The price is SAR 255
SAR 292 total
includes taxes & fees
10 Apr - 11 Apr

Hampton Inn Cape Girardeau I 55 East
Hampton Inn Cape Girardeau I 55 East
9.6 out of 10, Exceptional, (696)
The price is SAR 411
SAR 464 total
includes taxes & fees
6 Apr - 7 Apr

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MO
9.6 out of 10, Exceptional, (1003)
The price is SAR 338
SAR 357 total
includes taxes & fees
31 Mar - 1 Apr

Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
9.0 out of 10, Wonderful, (1001)
The price is SAR 287
SAR 324 total
includes taxes & fees
30 Mar - 31 Mar

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
9.4 out of 10, Exceptional, (910)
The price is SAR 354
SAR 400 total
includes taxes & fees
30 Mar - 31 Mar

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
8.4 out of 10, Very Good, (641)
The price is SAR 246
SAR 280 total
includes taxes & fees
27 Mar - 28 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find out more about Southeast Missouri
Find out more about Southeast Missouri
Recent reviews of Southeast Missouri hotels
Recent reviews of Southeast Missouri hotels

Drury Plaza Hotel Cape Girardeau Conference Center
5/5 Excellent
"The Drury was excellent. The room was sapcious and very clean. Breakfast in the morning was great. Easy access to the interstate."
A verified traveler stayed at Drury Plaza Hotel Cape Girardeau Conference Center
Posted 5 days ago

Drury Inn & Suites Cape Girardeau
5/5 Excellent
"Staff was polite and very helpful and attentive. Will stay here the next time I’m passing through."
A verified traveler stayed at Drury Inn & Suites Cape Girardeau
Posted 2 weeks ago
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More Hotel Options in Southeast Missouri
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- Historic Hotels in Southeast Missouri
- Hotel Wedding Venues in Southeast Missouri
- Hotel with a Concierge in Southeast Missouri
- Hotels with Bars in Southeast Missouri
- Hotels with Free Parking in Southeast Missouri
- Hotels with Hot Tubs in Southeast Missouri
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- Hotels with WiFi in Southeast Missouri
- Hotels with a Pool in Southeast Missouri
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- Hotels with smoking rooms in Southeast Missouri
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- Romantic Hotels in Southeast Missouri
- Shopping Hotels in Southeast Missouri
- Ski Hotels in Southeast Missouri
- Winery Hotels in Southeast Missouri
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Hotels near popular Southeast Missouri Attractions
- Hotels near Elephant Rocks State Park
- Hotels near Johnson's Shut-ins State Park
- Hotels near Southeast Missouri State University
- Hotels near Ozark National Scenic Riverways
- Hotels near Lake Wappapello
- Hotels near Echo Bluff State Park
- Hotels near Isle Casino Cape Girardeau
- Hotels near Big Spring
- Hotels near Alley Spring & Mill
- Hotels near Century Casino Caruthersville
Southeast Missouri Hotels by Star Rating
Explore more hotels
- Pear Tree Inn Sikeston
- Candlewood Suites Cape Girardeau by IHG
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Best Western Plus Sikeston
- Drury Inn & Suites Cape Girardeau
- New Orleans Inn Portageville
- Drury Inn & Suites Sikeston, MO
- Courtyard by Marriott Cape Girardeau Downtown
- Drury Inn & Suites Jackson MO
- Comfort Inn Festus - St Louis South
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Drury Inn & Suites Hayti Caruthersville
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Holiday Inn Express & Suites Perryville by IHG
- Quality Inn
- Quality Inn Farmington
- Town House Inn Cape Giradreau
- Super 8 by Wyndham Perryville
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
- Days Inn by Wyndham Perryville