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Compare Southeast Missouri Hotels with WiFi room rates, reviews, and availability. Most hotels are fully refundable.

Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
6.6 out of 10, (548)
The price is SAR 247
SAR 274 total
includes taxes & fees
13 Apr - 14 Apr

Microtel Inn & Suites by Wyndham Sainte Genevieve
Microtel Inn & Suites by Wyndham Sainte Genevieve
8.8 out of 10, Excellent, (558)
The price is SAR 301
SAR 335 total
includes taxes & fees
27 Apr - 28 Apr

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
9.4 out of 10, Exceptional, (1003)
The price is SAR 372
SAR 427 total
includes taxes & fees
13 Apr - 14 Apr

Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
8.0 out of 10, Very Good, (903)
The price is SAR 201
SAR 229 total
includes taxes & fees
13 Apr - 14 Apr

Town House Inn
Town House Inn
7.8 out of 10, Good, (392)
The price is SAR 243
SAR 263 total
includes taxes & fees
20 Apr - 21 Apr

Hampton Inn Cape Girardeau I 55 East
Hampton Inn Cape Girardeau I 55 East
9.6 out of 10, Exceptional, (699)
The price is SAR 412
SAR 464 total
includes taxes & fees
13 Apr - 14 Apr

Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
6.6 out of 10, (522)
The price is SAR 271
SAR 309 total
includes taxes & fees
6 May - 7 May

Eagle Inn Charleston
Eagle Inn Charleston
6.8 out of 10, (95)
The price is SAR 239
SAR 266 total
includes taxes & fees
7 Apr - 8 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find out more about Southeast Missouri
Find out more about Southeast Missouri
Recent reviews of Southeast Missouri hotels
Recent reviews of Southeast Missouri hotels

Drury Inn & Suites Cape Girardeau
5/5 Excellent
"5 Stars is not enough for all of the staff on duty April 4th, 2025. These folks are a SOLID 11! There was a genuine tornado approaching and they made sure all the lodgers were in safe spaces and appraised of what was going on. There was no hesitation of what to do, where to go and all was calm. Luckily, all was good.
Oh yeah the dinner & breakfast was great the place was clean and our room was fantastic. Value was excellent.
Allen B."
A verified traveler stayed at Drury Inn & Suites Cape Girardeau
Posted 1 day ago
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Hotels near popular Southeast Missouri Attractions
- Hotels near Elephant Rocks State Park
- Hotels near Johnson's Shut-ins State Park
- Hotels near Southeast Missouri State University
- Hotels near Ozark National Scenic Riverways
- Hotels near Lake Wappapello
- Hotels near Echo Bluff State Park
- Hotels near Isle Casino Cape Girardeau
- Hotels near Big Spring
- Hotels near Alley Spring & Mill
- Hotels near Century Casino Caruthersville
Southeast Missouri Hotels by Star Rating
Explore more hotels
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Best Western Plus Sikeston
- Drury Inn & Suites Sikeston, MO
- Candlewood Suites Cape Girardeau by IHG
- Drury Inn & Suites Cape Girardeau
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Super 8 by Wyndham Perryville
- Quality Inn
- Hampton Inn Sikeston
- Comfort Inn Festus - St Louis South
- Drury Inn & Suites Hayti Caruthersville
- Drury Inn & Suites Jackson MO
- Days Inn and Suites by Wyndham Sikeston
- Courtyard by Marriott Cape Girardeau Downtown
- Fairfield Inn & Suites by Marriott Cape Girardeau
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- Holiday Inn Express & Suites Perryville by IHG
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- Holiday Inn Poplar Bluff by IHG