Find 4 Star Hotels in Southeast Missouri, MO

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Check availability on Southeast Missouri 4 Star Hotels

Compare Southeast Missouri 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Silo Farm Haus- located in the heart of wine country!
Exterior

Silo Farm Haus- located in the heart of wine country!

10.0 out of 10, Exceptional, (138)
"We truly enjoyed our weekend stay at this little hideaway. It was about 15 min drive to Farmington and Ste Gen. Several wineries close by. The craftsmanship of the building is amazing. The only thing that would have made it better would be a hot tub. "
The price is SAR 896
SAR 1,312 total
includes taxes & fees
9 Feb - 10 Feb
Silo Farm Haus- located in the heart of wine country!
The Riverview
Exterior

The Riverview

3.5 star property
9.2 out of 10, Wonderful, (134)
"The room was spacious and clean. Beds were very comfortable. "
The price is SAR 364
SAR 410 total
includes taxes & fees
10 Feb - 11 Feb
The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center
Exterior

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1002)
"I've stayed here a few times when I'm in Cape Girardeau and it's always amazing "
The price is SAR 371
SAR 419 total
includes taxes & fees
12 Feb - 13 Feb
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Cape Girardeau
Exterior

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (885)
"Great for the price!"
The price is SAR 354
SAR 400 total
includes taxes & fees
12 Feb - 13 Feb
Drury Inn & Suites Cape Girardeau
Baymont Inn and Suites by Wyndham Farmington, MO
Exterior

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property
8.0 out of 10, Very Good, (847)
"I have been staying here for months and it has been a comfortable place to stay. Staff is pleasant and friendly, rooms are clean, and it feels safe. "
The price is SAR 204
SAR 232 total
includes taxes & fees
16 Feb - 17 Feb
Baymont Inn and Suites by Wyndham Farmington, MO
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1003)
"The staff! Everyone was so nice. They all seemed to love their job and were very helpful. The room was clean, quiet and spacious. We booked a room there again on a return trip. "
The price is SAR 371
SAR 419 total
includes taxes & fees
23 Feb - 24 Feb
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Days Inn and Suites by Wyndham Sikeston
Room

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1001)
"Great room"
The price is SAR 239
SAR 273 total
includes taxes & fees
13 Feb - 14 Feb
Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau West
Exterior

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1004)
"Nice stay "
The price is SAR 236
SAR 267 total
includes taxes & fees
19 Feb - 20 Feb
Pear Tree Inn Cape Girardeau West
Fairfield Inn & Suites by Marriott Cape Girardeau
Exterior

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
9.4 out of 10, Exceptional, (79)
"Excellent stay, very clean! Please add nightlights to the bathrooms"
The price is SAR 349
SAR 394 total
includes taxes & fees
20 Feb - 21 Feb
Fairfield Inn & Suites by Marriott Cape Girardeau
Candlewood Suites Cape Girardeau by IHG
Exterior

Candlewood Suites Cape Girardeau by IHG

2.5 star property
8.2 out of 10, Very Good, (727)
"Good location. Restaurants close by. Nice clean room."
The price is SAR 308
SAR 368 total
includes taxes & fees
10 Feb - 11 Feb
Candlewood Suites Cape Girardeau by IHG
Motel 6 Poplar Bluff, MO
Front of property

Motel 6 Poplar Bluff, MO

2.0 star property
8.0 out of 10, Very Good, (1001)
"The only place that we stay in Poplar Bluff"
The price is SAR 270
SAR 285 total
includes taxes & fees
16 Feb - 17 Feb
Motel 6 Poplar Bluff, MO
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Exterior

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

2.5 star property
9.0 out of 10, Wonderful, (501)
"Friendly staff and clean. No noise room comfortable."
The price is SAR 293
SAR 317 total
includes taxes & fees
20 Feb - 21 Feb
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Quality Inn
Exterior

Quality Inn

2.5 star property
7.0 out of 10, Good, (540)
"Cheap"
The price is SAR 229
SAR 259 total
includes taxes & fees
23 Feb - 24 Feb
Quality Inn
The Farmstead Hotel
Room

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (283)
"This property is a hidden gem, to say the least; the staff is invaluable and friendly, and the rooms are clean, updated, and priced well. I recommend staying here."
The price is SAR 368
SAR 418 total
includes taxes & fees
9 Feb - 10 Feb
The Farmstead Hotel
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Exterior

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

2.5 star property
8.0 out of 10, Very Good, (744)
"Convenience to Hwy. "
The price is SAR 328
SAR 375 total
includes taxes & fees
23 Feb - 24 Feb
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1001)
" CC"
The price is SAR 219
SAR 247 total
includes taxes & fees
20 Feb - 21 Feb
Pear Tree Inn Cape Girardeau Near the Medical Center
Fairfield Inn & Suites by Marriott Poplar Bluff
Exterior

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (687)
"Was good"
The price is SAR 386
SAR 436 total
includes taxes & fees
14 Feb - 15 Feb
Fairfield Inn & Suites by Marriott Poplar Bluff
Pear Tree Inn Sikeston
Exterior

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1004)
"Very clean and very friendly staff"
The price is SAR 304
SAR 349 total
includes taxes & fees
16 Feb - 17 Feb
Pear Tree Inn Sikeston
Drury Inn & Suites Hayti Caruthersville
Exterior

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1001)
"Awesome place. We were on a duck hunting trip. We will look for Drury from now on. Place is great "
The price is SAR 383
SAR 436 total
includes taxes & fees
16 Feb - 17 Feb
Drury Inn & Suites Hayti Caruthersville
Courtyard by Marriott Cape Girardeau Downtown
Property amenity

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
9.6 out of 10, Exceptional, (394)
" The hotel is excellent!! They done a wonderful job redoing the old buildings into a stunning hotel!! Highly recommend this hotel. "
The price is SAR 469
SAR 531 total
includes taxes & fees
23 Feb - 24 Feb
Courtyard by Marriott Cape Girardeau Downtown
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Frequently asked questions

How much does it cost to stay in a 4-star hotel in Southeast Missouri?
To book a 4-star hotel in Southeast Missouri that matches your budget, take advantage of Expedia’s handy search filters. Browse the available options during your chosen dates and use our pricing filter to set your limit. You can also list your results by the cheapest stay first.

  • Search for the lowest price

What's the difference between 5-star and 4-star hotels in Southeast Missouri?
Treat yourself to refined living during your Southeast Missouri vacation by choosing a 4-star hotel. As well as featuring upmarket surroundings, these retreats are typically packed with amenities, including complimentary bathrobes, large beds and more. A 5-star hotel will go above and beyond to make your trip an even more lavish and memorable one. 24-hour front desk, on-site spas and gourmet dining are a few of the superior services and conveniences you’ll likely have access to.
Does Southeast Missouri have any 4-star all-inclusive resorts?
Enjoy a stress-free vacation experience where everything is included in the upfront price by using our “All inclusive” filter. Budgeting is easy when your room, meals and many activities are already taken care of. Eager for more ideas? Check out the amazing deals on Expedia’s standard 4-star hotels in and around Southeast Missouri too.
What are the top 4-star apartments in Southeast Missouri?
Make yourself at home at Urban Lofts in Perryville, Southeast Missouri. Our 4-star apartments offer the space and convenience to fully embrace the local culture, while giving you all the necessary comforts for a memorable vacation.