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Compare 160 Vacation Homes in Panacea with updated reviews, rates, and availability.

Pet friendly Kayak with the manatees

2.0 star property
9.6 out of 10, Exceptional, (10)
"We really enjoyed the back deck for visiting and coffee drinkingThis was the perfect place for us to stay and prepare food to take to a family gathering in Crawfordville.The beds were comfortable with large tvs in each room. We hope to explore St. Marks on the water down the road next time we are here. It was all about 3 sisters getting together this time."
The price is SAR 506
SAR 987 total
includes taxes & fees
9 Feb - 10 Feb
Pet friendly Kayak with the manatees

Dragonfly on the Canal

2.0 star property
10.0 out of 10, Exceptional, (11)
"Clean and easy check-in, large TV with cable, nice large kitchen with everything you need, will stay here next time we come up to go fishing"
Dragonfly on the Canal

The Best Beach-Front House “Get-A-Way” in Florida

10.0 out of 10, Exceptional, (67)
"Best VRBO ever!!! The title of the property is correct! The beds are comfort plus, the view is amazing, it is well stocked in all areas, the front porch is a dream space…can’t think of one improvement to recommend. "
The Best Beach-Front House “Get-A-Way” in Florida

Happy Shack BEACH & BAY! Kayak, paddle boards, firepit, tiki hut, grille, wifi

10.0 out of 10, Exceptional, (210)
"We fished, swam, played, watched movies, cooked in the well-appointed kitchen and just generally had the best week in the Happy Shack. The bay beach was a surprisingly awesome amenity."
Happy Shack BEACH & BAY! Kayak, paddle boards, firepit, tiki hut, grille, wifi

Waterfront Panacea Vacation Rental w/ Boat Dock!

9.8 out of 10, Exceptional, (20)
"Beautiful home in a great location. Plenty of space inside the home. Very clean and not cluttered at all. The outside is stunning especially at sunset. There was room in the yard to play in the grass. My children loved it. The dock was very nice for fishing. The owner had great communication. We would love to stay there again."
Waterfront Panacea Vacation Rental w/ Boat Dock!

Beachfront ground floor! Screen porch, beach deck and boardwalk. Pet friendly

9.6 out of 10, Exceptional, (138)
"What a wonderful, old Florida house! The location is "
Beachfront ground floor! Screen porch, beach deck and boardwalk. Pet friendly

Fish, Beach, Pool, Swim, Relax

9.6 out of 10, Exceptional, (30)
"Awesome property for extended family with lots space be together or spread out. Great pool. Incredible view. "
Fish, Beach, Pool, Swim, Relax

Beachfront Alligator Point Retreat: Steps to Sand!

9.8 out of 10, Exceptional, (9)
"Loved this house!"
Beachfront Alligator Point Retreat: Steps to Sand!

Oceanfront on a Private Beach-Hot Tub-Beautifully Remodeled-Dog Friendly Beach

10.0 out of 10, Exceptional, (12)
"Our vacation was great! Melynda was amazing! She was great at communicating with us and the house has just about everything you need. Because of a hurricane, we had to leave our prior vacation spot and she was so generous in letting us come to the house one day early! We loved the house being on the beach and seeing dolphins everyday. Our kids loved all the extra things like the boogie boards, all the fishing supplies, the swings under the house, the games in the cabinet, and the hot tub. It was...
Oceanfront on a Private Beach-Hot Tub-Beautifully Remodeled-Dog Friendly Beach

Stay at Panacea Palms, a charming 3/2 less than 1 mile from local boat ramp!!

10.0 out of 10, Exceptional, (1)
"We will definitely be back! This rental property went far beyond our expectations and was the perfect home for a relaxing family getaway. The home was beautiful from the inside out with nice beach house decor and great size bedrooms. It was in a prime location next to great restaurants, a beautiful state park and a short drive to gorgeous beaches. "
Stay at Panacea Palms, a charming 3/2 less than 1 mile from local boat ramp!!

Beautiful beach,Ground Level with two Kitchens. Oceanfront Property on the Gulf

10.0 out of 10, Exceptional, (65)
"We love Reel Time and keep returning. Fabulous screen porch, well-stocked kitchen, great location. Helpful host."
Beautiful beach,Ground Level with two Kitchens. Oceanfront Property on the Gulf

Gulf to Bay, on the beach home with bay access

10.0 out of 10, Exceptional, (10)
"Nothing beats beachfront! We loved sitting on the screened porch, cooking in the big kitchen, and letting the kids play under the house. We will be back!"
Gulf to Bay, on the beach home with bay access

PRIVATE LUXURY BEACHFRONT HOME! - WINTER DISCOUNTS!

10.0 out of 10, Exceptional, (92)
"This was our first reunion of what we hope to be many! The house was beautiful, and the kitchen was gourmet with all the trappings for entertaining and dining. The dining table was large enough for most of us to gather at once and the bar stools made us complete. The weather was not ideal, but the spacious living room provided us plenty of room to socialize and play games while still enjoying the view. The dolphin were very active and we could see them all the time. Nikki was a responsive...
PRIVATE LUXURY BEACHFRONT HOME! - WINTER DISCOUNTS!

Beachfront bungalow with private direct beach access. Sleeps 8. Pet friendly!

9.8 out of 10, Exceptional, (105)
"Cozy cottage with perfect views! The outdoor fire pit was very much enjoyed and the porch provided for excellent story telling and making of memories! "
Beachfront bungalow with private direct beach access. Sleeps 8. Pet friendly!

NEW LISTING! - Brand new 4BR/2BA ,100 steps to the beach!

9.8 out of 10, Exceptional, (25)
"We thoroughly enjoyed our stay, plenty of room to socialize both inside and outside. We loved the screened porch for relaxing and the well stocked kitchen made us feel right at home. And we all agree the beds - all of the beds - were a real delight. Parking was plentiful and the neighborhood quiet and peaceful, and well maintained. The beach access was wonderful! We hope to come back next year. "
NEW LISTING! - Brand new 4BR/2BA ,100 steps to the beach!

Unique Beach Front gathering spot for family, friends and PUPs.

10.0 out of 10, Exceptional, (26)
"Beautiful location and great house. We already booked our return trip!"
Unique Beach Front gathering spot for family, friends and PUPs.

'Sea Palms' - Luxury 5 Bedroom Beachfront Home

10.0 out of 10, Exceptional, (118)
"Great location peaceful and quiet really enjoyed our stay and our two grandchildren were never bored. We left our canopy and beach chairs on the beach no one bothered them, we did however lose the canopy to the ocean when the wind came up 😂. We would definitely put this location again. "
'Sea Palms' - Luxury 5 Bedroom Beachfront Home

LAKE, BEACH, MARINA, FISHING, NATURE HIKING, THIS HOME HAS IT ALL!

10.0 out of 10, Exceptional, (8)
"Great area for fishing trip, lacking firepit, grill and basic cooking utensils"
LAKE, BEACH, MARINA, FISHING, NATURE HIKING, THIS HOME HAS IT ALL!

Waterfront Escape w/ Balcony on Shell Point Beach!

10.0 out of 10, Exceptional, (30)
"Best view for a gin and tonic ever"
Waterfront Escape w/ Balcony on Shell Point Beach!

Waterfront Home: Spectacular On-Site Fishing!

9.4 out of 10, Exceptional, (20)
"We enjoyed our stay immensely - the property is perfectly appointed with every amenity you can possibly need, and we especially enjoyed fishing and relaxing in the downstairs sitting area by the fire pit. We already made a reservation to come back in the spring!"
Waterfront Home: Spectacular On-Site Fishing!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Panacea

Hideaway Beach Cottage on waterfront with amazing views.

10.0 out of 10, Exceptional, (32)
"The cottage in Panacea was very cute and clean"
Hideaway Beach Cottage on waterfront with amazing views.

Happy Shack BEACH & BAY! Kayak, paddle boards, firepit, tiki hut, grille, wifi

10.0 out of 10, Exceptional, (210)
"We fished, swam, played, watched movies, cooked in the well-appointed kitchen and just generally had the best week in the Happy Shack. The bay beach was a surprisingly awesome amenity."
Happy Shack BEACH & BAY! Kayak, paddle boards, firepit, tiki hut, grille, wifi

The Best Beach-Front House “Get-A-Way” in Florida

10.0 out of 10, Exceptional, (67)
"Best VRBO ever!!! The title of the property is correct! The beds are comfort plus, the view is amazing, it is well stocked in all areas, the front porch is a dream space…can’t think of one improvement to recommend. "
The Best Beach-Front House “Get-A-Way” in Florida
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.