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Find Resorts & Hotels with Spas in Cape Girardeau, MO

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Check availability on Cape Girardeau Resorts & Hotels with Spas

Compare Cape Girardeau Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Hampton Inn Cape Girardeau I 55 East
Courtyard

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (701)
"Great experience "
The price is SAR 412
SAR 464 total
includes taxes & fees
20 Apr - 21 Apr
Hampton Inn Cape Girardeau I 55 East
Pear Tree Inn Cape Girardeau West
Lobby

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1004)
"Breakfast below average coffee good "
The price is SAR 270
SAR 305 total
includes taxes & fees
17 Apr - 18 Apr
Pear Tree Inn Cape Girardeau West
Drury Inn & Suites Cape Girardeau
Business center

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (917)
"5 Stars is not enough for all of the staff on duty April 4th, 2025. These folks are a SOLID 11! There was a genuine tornado approaching and they made sure all the lodgers were in safe spaces and appraised of what was going on. There was no hesitation of what to do, where to go and all was calm. Luckily, all was good. Oh yeah the dinner & breakfast was great the place was clean and our room was fantastic. Value was excellent. Allen B."
The price is SAR 355
SAR 400 total
includes taxes & fees
18 Apr - 19 Apr
Drury Inn & Suites Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1007)
"This was our first time at a Drury hotel so it came as quite a surprise that they provide supper as well as breakfast. Clean, well-kept motel; friendly, helpful staff."
The price is SAR 355
SAR 400 total
includes taxes & fees
17 Apr - 18 Apr
Drury Plaza Hotel Cape Girardeau Conference Center
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1003)
"Will definitely stay there again!!"
The price is SAR 387
SAR 436 total
includes taxes & fees
4 May - 5 May
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Candlewood Suites Cape Girardeau by IHG
Exterior

Candlewood Suites Cape Girardeau by IHG

2.5 star property
8.2 out of 10, Very Good, (765)
"Very nice place to stay and friendly people"
The price is SAR 308
SAR 368 total
includes taxes & fees
20 Apr - 21 Apr
Candlewood Suites Cape Girardeau by IHG
Pear Tree Inn Cape Girardeau Near the Medical Center
Seasonal outdoor pool

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1005)
"Absolutely wonderful friendly people great location very clean! I love it "
The price is SAR 253
SAR 286 total
includes taxes & fees
20 Apr - 21 Apr
Pear Tree Inn Cape Girardeau Near the Medical Center
Town House Inn Cape Giradreau
Desk, free WiFi

Town House Inn Cape Giradreau

2.5 star property
6.0 out of 10, (178)
"NA"
The price is SAR 237
SAR 276 total
includes taxes & fees
14 Apr - 15 Apr
Town House Inn Cape Giradreau
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Exterior

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

8.8 out of 10, Excellent, (28)
"all was so nice and we enjoyed our stay. grandkids and us loved having pool table and card games and all the peace and quiet there. thank u again for contacting me and giving us address. we appreciated that very much. "
The price is SAR 563
SAR 877 total
includes taxes & fees
22 Apr - 23 Apr
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Serenity South -- Gardens, River-Views, and Refreshing Space
Fridge, microwave, oven, stovetop

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (130)
"When looking for a VRBO for our daughter's college visit, we knew the perfect place to stay! This is our second stay at Serenity South and it was just as incredible as the first visit. Clean, inviting and cozy. Thanks Jo for another beautiful stay."
The price is SAR 563
SAR 920 total
includes taxes & fees
14 Apr - 15 Apr
Serenity South -- Gardens, River-Views, and Refreshing Space
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Cape Girardeau?
Treat yourself to some pampering and book a hotel with a spa. Travelers recommend the gourmet restaurants in Cape Girardeau. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Cape Girardeau?
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top spa hotel featuring a pool and a fitness center.
How many spa hotels will I find in Cape Girardeau?
Among Expedia’s 58 accommodation options in Cape Girardeau, there is 1 spa hotel.
What's there to see and do in Cape Girardeau?
Experience all that Cape Girardeau has to offer when you visit Isle Casino Cape Girardeau, Show Me Center, and Hunter Valley Winery. If you have a bit of extra time while you’re in the area, you might want to check out Trail of Tears State Park and Shawnee National Forest.
What is a Cape Girardeau spa hotel?
Spa hotels in Cape Girardeau have full on-site spas offering services such as massages and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.