Photo by Skyy

Find Luxury Hotels in Cape Girardeau, MO

  • Plan, book, stay with confidence

    • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    today icon
    Change your mind
    Book hotels with free cancellation

Check availability on Cape Girardeau Luxury Hotels

Compare Cape Girardeau Luxury Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Property grounds

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

10.0 out of 10, Exceptional, (212)
"There couldn’t be a better location for going out on the riverfront in Cape Girardeau. It is well set up with beautiful furniture and all the kitchen supplies you would need. Highly recommend. "
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Pear Tree Inn Cape Girardeau Near the Medical Center
Seasonal outdoor pool

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1002)
"It was small room but was okay "
The price is SAR 253
SAR 286 total
includes taxes & fees
13 Apr - 14 Apr
Pear Tree Inn Cape Girardeau Near the Medical Center
Quality Inn
Lobby

Quality Inn

2.5 star property
7.0 out of 10, Good, (561)
"Love it very clean and very quiet love the experience"
The price is SAR 251
SAR 284 total
includes taxes & fees
8 Apr - 9 Apr
Quality Inn
Drury Inn & Suites Cape Girardeau
Business center

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (916)
"5 Stars is not enough for all of the staff on duty April 4th, 2025. These folks are a SOLID 11! There was a genuine tornado approaching and they made sure all the lodgers were in safe spaces and appraised of what was going on. There was no hesitation of what to do, where to go and all was calm. Luckily, all was good. Oh yeah the dinner & breakfast was great the place was clean and our room was fantastic. Value was excellent. Allen B."
The price is SAR 355
SAR 400 total
includes taxes & fees
27 Apr - 28 Apr
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Cape Girardeau

Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to Cape Girardeau?
Use Expedia to arrange your flight to Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport or Cairo, IL (CIR-Cairo Regional) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a vacation, so we make it easy to get what you’d like to make your stay relaxing and comfortable. If you want an upscale hotel that has fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Cape Girardeau offers. During your visit, you might want to enjoy the university which Cape Girardeau is known for.
How many luxury hotels will I find in Cape Girardeau?
Lie in the lap of luxury during your getaway to Cape Girardeau in one of Expedia’s 6 luxury hotels.
When can I expect good weather in Cape Girardeau?
Planning for the weather is an important factor for making your trip to Cape Girardeau a success, especially when you’re splurging. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Cape Girardeau is 59 inches.
What's there to see and do in Cape Girardeau?
Enjoy all that Cape Girardeau has to offer and visit Isle Casino Cape Girardeau, Show Me Center, and Hunter Valley Winery. If you have a bit of extra time while you’re in the area, you might want to check out Trail of Tears State Park and Shawnee National Forest.