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Find Luxury Hotels in Cape Girardeau, MO

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Compare Cape Girardeau Luxury Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1002)
"clean room. barking dog"
The price is SAR 220
SAR 248 total
includes taxes & fees
26 Dec - 27 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center
Quality Inn
Exterior

Quality Inn

2.5 star property
7.0 out of 10, Good, (523)
"It was quite and clean"
The price is SAR 229
SAR 258 total
includes taxes & fees
24 Dec - 25 Dec
Quality Inn
Drury Inn & Suites Cape Girardeau
Exterior

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (845)
"The staff was super friendly. Really good!"
The price is SAR 338
SAR 381 total
includes taxes & fees
28 Dec - 29 Dec
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to Cape Girardeau?
Use Expedia to arrange your flight to Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport or Cairo, IL (CIR-Cairo Regional) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a vacation, so we make it easy to get what you’d like to make your stay relaxing and comfortable. If you want an upscale hotel that has fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Cape Girardeau offers. During your visit, you might want to enjoy the university which Cape Girardeau is known for.
How many luxury hotels will I find in Cape Girardeau?
Lie in the lap of luxury during your getaway to Cape Girardeau in one of Expedia’s 6 luxury hotels.
When can I expect good weather in Cape Girardeau?
Planning for the weather is an important factor for making your trip to Cape Girardeau a success, especially when you’re splurging. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Cape Girardeau is 59 inches.
What's there to see and do in Cape Girardeau?
Enjoy all that Cape Girardeau has to offer and visit Riverfront Park, eDen Spa & Salon, and Isle Casino Cape Girardeau. If you have a bit of extra time while you’re in the area, you might want to check out Riverfront Bridge Park and Show Me Center.