Search Vacation Homes in St. Charles

  • Plan, book, stay with confidence

  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check prices for these dates

Next weekend
In two weeks
In one month

Compare 154 Vacation Homes in St. Charles with updated reviews, rates, and availability.

Cheshire House // Family Home, Fenced Yard, Pet Friendly, 2 mi from Mayo Clinic

10.0 out of 10, Exceptional, (35)
"This is a very comfortable home. I’m a patient at Mayo Clinic and need to be there every 2 weeks for a couple of months then every 12 weeks, we hope to book this house every time. Large backyard for our dog's and easy access to Mayo. The property owners are a blessing to work with. Easy to approach and very kind. Highly recommend their properties. "
Cheshire House // Family Home, Fenced Yard, Pet Friendly, 2 mi from Mayo Clinic

Elegant & Secure Family Abode Grand 4-Bedroom Retreat (Entire House)

10.0 out of 10, Exceptional, (4)
"Spacious, clean home in a great neighborhood. Emmy was very accommodating. Perfect place for us to gather for a weekend in Rochester. "
Elegant & Secure Family Abode Grand 4-Bedroom Retreat (Entire House)

Bluffside cottage with gorgeous river views

10.0 out of 10, Exceptional, (19)
"Excellence.... The property, the host, the process were all amazing!!! I would recommend this property to everyone. "
Bluffside cottage with gorgeous river views

Fresh space near Mayo Clinic and downtown

9.6 out of 10, Exceptional, (16)
"Very clean property. It was comfortable and cute. The owners were responsive to us and so helpful"
Fresh space near Mayo Clinic and downtown

Charming Brick Farmhouse with a Touch of Elegance. -Winona

10.0 out of 10, Exceptional, (120)
"Our family stayed at the Village House Inn over Christmas and it was perfect for accommodating a large group very comfortably. The location and proximity to Winona was also ideal. We will definitely be back! "
The price is SAR 1,088
SAR 1,796 total
includes taxes & fees
26 Jan - 27 Jan
Charming Brick Farmhouse with a Touch of Elegance. -Winona

Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown

10.0 out of 10, Exceptional, (27)
"Would stay again! Thank you!"
Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown

Charming 3-bedroom, 2 bathroom house with outdoor space in Winona

10.0 out of 10, Exceptional, (11)
"the inside was beautiful. the neighborhood was decent and quiet. very comfortable stay!"
The price is SAR 881
SAR 1,067 total
includes taxes & fees
24 Feb - 25 Feb
Charming 3-bedroom, 2 bathroom house with outdoor space in Winona

Kutzky Cottage // 3 BR, 4 Blocks to Mayo, Family & Pet Friendly, Fenced Yard

10.0 out of 10, Exceptional, (10)
"We had appointments at Mayo, so stayed here for a week. It is extremely clean, the kitchen is set up well. We literally drove straight down the street about a mile to the main Mayo clinics. It was very comfortable, and the owners communication was excellent.There are just a couple quirks. The highs were in the single digits and lows below zero the first few days there. This is an older home, probably built in the 40s. It has been fixed up well, but it was very chilly upstairs, and the...
Kutzky Cottage // 3 BR, 4 Blocks to Mayo, Family & Pet Friendly, Fenced Yard

Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!

10.0 out of 10, Exceptional, (64)
"The views are absolutely breathtaking! And the house itself, was more beautiful than the pictures could ever capture! The amenities were awesome and kept us busy! Definitely a 5 out of 5!! "
Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!

Welcoming mid-century modern history-friendly home in bluff county.

10.0 out of 10, Exceptional, (21)
"House is clean and comfortable. Tammy is very easy to communicate with. The location is convenient to many areas of interest in the region. "
Welcoming mid-century modern history-friendly home in bluff county.

☆Oakley's Oasis, a Dharma Dwellings Designed Home☆

10.0 out of 10, Exceptional, (29)
"Overall a comfy, cozy stay. Would consider returning with the only issue being we wish there was a king bed. The queen was a bit too cramped to be comfy."
☆Oakley's Oasis, a Dharma Dwellings Designed Home☆

RitaBNB 907 14th Unit #1 · Cozy 2BR close to Mayo (14#1)

8.0 out of 10, Very Good, (1)
"I needed a space for my pregnant daughter, her husband, and their toddler because their furnace died on Christmas Eve. I selected this property because it was reasonably priced and was rated as an "exceptional” property. The space is nice with good access to the Mayo Clinic. However, at the risk of getting a bad renter review, I do not think the property has earned its “exceptional” property rating.First, there were none of the extra’s you usually see at an "exceptional" property. There was no...
RitaBNB 907 14th Unit #1 · Cozy 2BR close to Mayo (14#1)

3 miles to Mayo, Four bed home, Covered By Faith

2.0 star property
6.0 out of 10, (1)
"It was ok but when we came we had to clean first, and fix appliances which the tenants were very helpful with. "
3 miles to Mayo, Four bed home, Covered By Faith

City Hall Recorder's Office

2.0 star property
10.0 out of 10, Exceptional, (4)
"Property is just as stated and was n walking distance to Mayo and places to eat. The apartment had everything someone would need. Management sent good efficient communication regarding check in and out process."
The price is SAR 364
SAR 873 total
includes taxes & fees
8 Feb - 9 Feb
City Hall Recorder's Office

The River Cabin Summ

10.0 out of 10, Exceptional, (8)
"It was just beautiful!"
The River Cabin Summ

Century Cottage-PERFECT for Mayo & downtown visitors!

10.0 out of 10, Exceptional, (104)
"House was clean guest left a bag of local coffee excellent recommendations (we got the Saturday special bread from the bakery!!). Great communication three queen beds for comfort"
Century Cottage-PERFECT for Mayo & downtown visitors!

Logde sleeps 11 ...set up for exploring the Mississippi River or Driftless Area.

10.0 out of 10, Exceptional, (43)
"It is conveniently located; excellent hosts; property is great."
The price is SAR 619
SAR 744 total
includes taxes & fees
25 Jan - 26 Jan
Logde sleeps 11 ...set up for exploring the Mississippi River or Driftless Area.

Within walking distance of all the amenities! Bike the trail~ float the river

10.0 out of 10, Exceptional, (10)
"The house was great! Kitchen is well stocked and we felt right at home. We would love to come back again!"
Within walking distance of all the amenities! Bike the trail~ float the river

☆Dee Dee's Den: A Dharma Dwellings Parent Company☆

10.0 out of 10, Exceptional, (29)
"The host was excellent and accomodating. We spent the weekend with a long time friend that is experiencing a difficult battle with cancer at the Mayo. The rental provided a comfortable worry free experience that provided an excellent central point for meeting up with others and providing access to local ammenties and attractions. "
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆

Park in the Garage and Walk to Mayo Clinic

10.0 out of 10, Exceptional, (53)
"Have had to come up to Mayo twice for appointments and stayed here both times. Place makes you feel at home very comfortable and cozy. Large kitchen plenty of space. Bed is amazing and cozy. Host was easy to communicate with and very nice. "
Park in the Garage and Walk to Mayo Clinic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in St. Charles
Save an average of 15% on thousands of hotels when you're signed in

Other property types in St. Charles

The Berkman

3.0 star property
9.6 out of 10, Exceptional, (262)
"We are repeat customers of the Berkman. It’s always five stars. The hotel is beautiful, clean, and very accommodating. It’s always our first choice in Rochester. "
The price is SAR 491
SAR 571 total
includes taxes & fees
26 Jan - 27 Jan
The Berkman

Heritage hideaway-Secluded Log Cabin

10.0 out of 10, Exceptional, (362)
"This is the second time staying at this cabin and we love the setting the decor the vibe and everything! A great getaway!"
Heritage hideaway-Secluded Log Cabin

Broadway Plaza, Trademark Collection by Wyndham

3.0 star property
9.2 out of 10, Wonderful, (147)
"Very good"
Broadway Plaza, Trademark Collection by Wyndham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.