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Compare 159 Vacation Homes in St. Charles with updated reviews, rates, and availability.

Family friendly in the peaceful heart of town
Kitchen. Ladder can be removed. Everyday needs are easily in reach on shelves.

Family friendly in the peaceful heart of town

10.0 out of 10, Exceptional, (86)
"Beautiful home with super comfy beds and excellent space to enjoy a friend getaway. Clean home with everything we needed and super wash to access. Owner was SO responsive and super quick with anything questions. Definitely will stay again in a heartbeat!"
Family friendly in the peaceful heart of town
Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly
Eat-in kitchen

Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly

9.8 out of 10, Exceptional, (52)
"We had to gather a lot of family on short notice to say goodbye to a dying family member and this space was perfect for us all to gather and grieve together. There was plenty of sleeping space for everyone and it was conveniently lovlcated near parks and walking trails for our kiddos."
Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly
Welcoming mid-century modern history-friendly home in bluff county.
This bright, romantic master is the perfect place to relax. Winter shown here.

Welcoming mid-century modern history-friendly home in bluff county.

10.0 out of 10, Exceptional, (21)
"House is clean and comfortable. Tammy is very easy to communicate with. The location is convenient to many areas of interest in the region. "
Welcoming mid-century modern history-friendly home in bluff county.
Lots of charm and only blocks away from the Root River and Bike trails
Exterior detail

Lots of charm and only blocks away from the Root River and Bike trails

10.0 out of 10, Exceptional, (14)
"Pauline was very kid and helpful the was clean cozy. It was a great Location for the funneral we had to tend to. I alos live all the bored games great safe family atopmshere "
Lots of charm and only blocks away from the Root River and Bike trails
Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!
You'll have endless fun in our endless pool! Overlooks the Mississippi River!

Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!

10.0 out of 10, Exceptional, (61)
"We love our whole experience. Home was very clean, check in was a breeze, and so much to do. The host was easy to communicate with. They had the most wonderful and thoughtful welcome basket. Highly recommend this home and we will definitely be back in the future."
Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!
Root River Retreat
Living room / family room . Sofa, chairs , pub table and Tv

Root River Retreat

9.6 out of 10, Exceptional, (35)
"Lori is a wonderful host - the property is just as described and extremely clean. The 2 bedrooms are beautiful with plenty of natural light. The main area has all you need for a long weekend - a couch, 2 comfortable chairs, high top table, sizeable fridge/freezer, breakfast bar area, ginormous TV...all very comfortable! There is garage space to store bikes, if you are in the area for cycling. The home is located in a quiet neighborhood with easy access to all the surrounding communities. Lori...
Root River Retreat
Fresh space near Mayo Clinic and downtown
Living room, which is open to the dining room

Fresh space near Mayo Clinic and downtown

9.6 out of 10, Exceptional, (16)
"Very clean property. It was comfortable and cute. The owners were responsive to us and so helpful"
Fresh space near Mayo Clinic and downtown
The Broadway Exchange
Bathroom

The Broadway Exchange

9.8 out of 10, Exceptional, (18)
"Comfy beds. Good gathering spaces…living room, kitchen island, dining room. Outdoor space too. "
The Broadway Exchange
Single Level Living with Comfortable Recliners
Open concept living. A third chair has been added by the lamp.

Single Level Living with Comfortable Recliners

10.0 out of 10, Exceptional, (29)
"This was our very first experience with a VRBO. It exceeded our expectations in every aspect including but not limited to the following: communicating with the property manager, cleanliness, kitchen supplies, bathroom accessories, up to date appliances, comfy recliners, easy instructions for TV/cable remotes… The host was responsive to short notice special requests we were in need of as well. This property definitely felt like “home away home”…good “vibes”. Quiet neighborhood with easy...
Single Level Living with Comfortable Recliners
Century Cottage-PERFECT for Mayo & downtown visitors!
Cozy and spacious

Century Cottage-PERFECT for Mayo & downtown visitors!

10.0 out of 10, Exceptional, (101)
"We had a girls weekend and did some baking and shopping"
Century Cottage-PERFECT for Mayo & downtown visitors!
Vintage Lustron Home Piece of History
Room

Vintage Lustron Home Piece of History

10.0 out of 10, Exceptional, (16)
"My grandparents owned a Lustron home, so staying here was like revisiting fond childhood memories. Back then, the home didn't seem so unusual; now it's definitely a post-war time capsule. The original features are in very good condition and the home is spotlessly clean. Everything was as described, very comfortable and in good working order. Appreciated the snacks in the kitchen. "
The price is SAR 375
SAR 645 total
includes taxes & fees
24 Nov - 25 Nov
Vintage Lustron Home Piece of History
Delightful family home near pool, playground, park, nature center 1.6 mi to Mayo
Home Front

Delightful family home near pool, playground, park, nature center 1.6 mi to Mayo

10.0 out of 10, Exceptional, (23)
"A family member had several day appointments at the Mayo. He has mobility iaauws. Thia home eas perfect. 1 level. Walk-in shower. Bed with head and feet incline."
Delightful family home near pool, playground, park, nature center 1.6 mi to Mayo
Charming 3-bedroom, 2 bathroom house with outdoor space in Winona
Exterior

Charming 3-bedroom, 2 bathroom house with outdoor space in Winona

10.0 out of 10, Exceptional, (11)
"the inside was beautiful. the neighborhood was decent and quiet. very comfortable stay!"
The price is SAR 882
SAR 1,084 total
includes taxes & fees
24 Nov - 25 Nov
Charming 3-bedroom, 2 bathroom house with outdoor space in Winona
2023 Construction, 5 BR, Gym, Game Area
Living room

2023 Construction, 5 BR, Gym, Game Area

10.0 out of 10, Exceptional, (14)
"The best luxurious home in Rochester MN "
2023 Construction, 5 BR, Gym, Game Area
Kutzky Cottage // 3 BR, 4 Blocks to Mayo, Family & Pet Friendly, Fenced Yard
Living area

Kutzky Cottage // 3 BR, 4 Blocks to Mayo, Family & Pet Friendly, Fenced Yard

10.0 out of 10, Exceptional, (8)
"Beautiful property. Very clean and well organized. Great space for our dog!"
Kutzky Cottage // 3 BR, 4 Blocks to Mayo, Family & Pet Friendly, Fenced Yard
City Hall Recorder's Office
Living Area

City Hall Recorder's Office

2.0 star property
10.0 out of 10, Exceptional, (2)
"We were there for the Mayo experience. We walked pretty much every day. Only a 10 minute walk to most of the buildings. Lots of good food within walking distance too"
The price is SAR 267
SAR 761 total
includes taxes & fees
27 Nov - 28 Nov
City Hall Recorder's Office
The River Cabin Summ

The River Cabin Summ

10.0 out of 10, Exceptional, (8)
"It was just beautiful!"
The River Cabin Summ
Mississippi River View with updated driveway

Mississippi River View with updated driveway

9.4 out of 10, Exceptional, (126)
"The inside of the house was great!"
Mississippi River View with updated driveway
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆
Welcome to Dee Dee's Den! We are pleased to offer this home for you!

☆Dee Dee's Den: A Dharma Dwellings Parent Company☆

10.0 out of 10, Exceptional, (22)
"Every year my friends and family travel for a week. We are Combat Veterans, ranging from the Vietnam War to the Iraq and Afghanistan wars. This was the best house we have ever stayed in."
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆
Park in the Garage and Walk to Mayo Clinic
King size bed with memory foam mattress in primary bedroom located upstairs.

Park in the Garage and Walk to Mayo Clinic

10.0 out of 10, Exceptional, (51)
"We stayed during medical visits at Mayo and enjoyed being able to walk to the clinic, come back and relax in such a comfortable place. Excellent communication from Jill, the owner, "
Park in the Garage and Walk to Mayo Clinic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in St. Charles

The Berkman
Lobby

The Berkman

3.0 star property
9.6 out of 10, Exceptional, (254)
"Clean & enjoyable stay. "
The price is SAR 628
SAR 730 total
includes taxes & fees
13 Dec - 14 Dec
The Berkman
Heritage hideaway-Secluded Log Cabin
Front patio area with charcoal grill

Heritage hideaway-Secluded Log Cabin

10.0 out of 10, Exceptional, (357)
"My wife and I stayed here a few years ago and loved everything about this place, so when the opportunity came for me to take a vacation on my own, I knew where I was going. It's so nuce how quuet and secluded it is here. You'll have basically everything you need for a nice stay here. "
Heritage hideaway-Secluded Log Cabin
Broadway Plaza, Trademark Collection by Wyndham
Room

Broadway Plaza, Trademark Collection by Wyndham

3.0 star property
9.2 out of 10, Wonderful, (145)
"Great place to stay. Very handy for walking to the Mayo Clinic. Also very clean. Although we only stayed one night, it would be especially nice for longer stays as it really is a small apartment."
Broadway Plaza, Trademark Collection by Wyndham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.