Find Business Hotels in Southeast Illinois, IL
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Southeast Illinois Business Hotels
Tonight
Tomorrow
This weekend
Next weekend
Compare Southeast Illinois Business Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Harrah's Metropolis Hotel & Casino
Harrah's Metropolis Hotel & Casino
8.2 out of 10, Very Good, (1003)
The price is SAR 368
SAR 468 total
includes taxes & fees
26 May - 27 May

Super 8 by Wyndham Mattoon
Super 8 by Wyndham Mattoon
7.4 out of 10, Good, (671)
The price is SAR 261
SAR 293 total
includes taxes & fees
18 May - 19 May

Holiday Inn Express And Suites Effingham by IHG
Holiday Inn Express And Suites Effingham by IHG
9.4 out of 10, Exceptional, (1000)
The price is SAR 428
SAR 479 total
includes taxes & fees
4 May - 5 May

Holiday Inn Express & Suites Mattoon by IHG
Holiday Inn Express & Suites Mattoon by IHG
8.2 out of 10, Very Good, (705)
The price is SAR 443
SAR 496 total
includes taxes & fees
4 May - 5 May

Country Inn & Suites by Radisson, Effingham, IL
Country Inn & Suites by Radisson, Effingham, IL
8.8 out of 10, Excellent, (1003)
The price is SAR 367
SAR 407 total
includes taxes & fees
6 May - 7 May

Unique Suites Hotel
Unique Suites Hotel
8.6 out of 10, Excellent, (633)
The price is SAR 317
SAR 362 total
includes taxes & fees
28 Apr - 29 Apr

Clarion Pointe Mattoon near University
Clarion Pointe Mattoon near University
8.4 out of 10, Very Good, (809)
The price is SAR 367
SAR 411 total
includes taxes & fees
6 May - 7 May

Holiday Inn Effingham by IHG
Holiday Inn Effingham by IHG
9.2 out of 10, Wonderful, (597)
The price is SAR 394
SAR 441 total
includes taxes & fees
4 May - 5 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find out more about Southeast Illinois
Find out more about Southeast Illinois
Recent reviews of Southeast Illinois hotels
Recent reviews of Southeast Illinois hotels

Comfort Suites Mount Vernon
5/5 Excellent
"Very quiet in a busy area. Clean, nicely updat d, good breakfast and very friendly staff. This will be my go to place, half way between home and my sisters place."
A verified traveler stayed at Comfort Suites Mount Vernon
Posted 23 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Find More Hotels near Southeast Illinois
More Hotel Options in Southeast Illinois
- Adventure Hotels in Southeast Illinois
- Beach Hotels in Southeast Illinois
- Casinos in Southeast Illinois
- Cheap Hotels in Southeast Illinois
- Family Hotels in Southeast Illinois
- Golf Hotels in Southeast Illinois
- Green Hotels in Southeast Illinois
- Historic Hotels in Southeast Illinois
- Hotel Wedding Venues in Southeast Illinois
- Hotel with a Concierge in Southeast Illinois
- Hotels with Bars in Southeast Illinois
- Hotels with Free Parking in Southeast Illinois
- Hotels with Hot Tubs in Southeast Illinois
- Hotels with WiFi in Southeast Illinois
- Hotels with a Pool in Southeast Illinois
- Hotels with an Indoor Pool in Southeast Illinois
- Hotels with smoking rooms in Southeast Illinois
- Luxury Hotels in Southeast Illinois
- Pet-friendly Hotels in Southeast Illinois
- Resorts & Hotels with Spas in Southeast Illinois
- Romantic Hotels in Southeast Illinois
- Scuba Diving in Southeast Illinois
- Shopping Hotels in Southeast Illinois
- Ski Hotels in Southeast Illinois
- Winery Hotels in Southeast Illinois
More Accommodation Types in Southeast Illinois
- Vacation Homes in Illinois
- Apartments in Illinois
- Condo Rentals in Illinois
- Cabin Rentals in Illinois
- Motels in Illinois
- Cottages in Illinois
- Aparthotels in Illinois
- B&B in Illinois
- Villas in Illinois
- Guest Houses in Illinois
- RV Parks in Illinois
- Lodges in Illinois
- Resorts in Illinois
- Inns in Illinois
- Hostels in Illinois
- Country Houses in Illinois
- Holiday Park Resorts in Illinois
- Residences in Illinois
Hotels near popular Southeast Illinois Attractions
- Hotels near Shawnee National Forest
- Hotels near Harrah's Metropolis
- Hotels near Garden of the Gods Recreation Area
- Hotels near Lake Sara
- Hotels near Superman Statue
- Hotels near Cave in Rock State Park
- Hotels near Tunnel Hill State Trail
- Hotels near World's Largest Mailbox
- Hotels near Dixon Springs State Park
- Hotels near Effingham Performance Center
Southeast Illinois Hotels by Star Rating
Explore more hotels
- Drury Plaza Hotel Mt. Vernon
- Terre Haute Casino Resort
- Drury Inn & Suites Marion
- Baymont by Wyndham Marion
- Comfort Suites Mount Vernon
- La Quinta Inn & Suites by Wyndham Terre Haute
- Holiday Inn Terre Haute by IHG
- Walker's Bluff Casino Resort
- La Quinta Inn & Suites by Wyndham Paducah
- Drury Inn & Suites Terre Haute
- Auburn Place Hotel & Suites - Paducah
- Comfort Suites
- Holiday Inn Express Hotel & Suites Paducah West by IHG
- Super 8 by Wyndham Paducah I-24 Exit 4
- Sleep Inn Terre Haute University Area
- The 1857
- Comfort Inn Paducah I-24
- Holiday Inn Paducah Riverfront by IHG
- DoubleTree by Hilton Mt. Vernon
- Fairfield Inn & Suites Terre Haute