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Discover 8,685 Serra Mesa hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Sycuan Casino Resort
Sycuan Casino Resort
9.2 out of 10, Wonderful, (1115)
The price is SAR 323
SAR 400 total
includes taxes & fees
5 Mar - 6 Mar

Days Inn by Wyndham San Diego-East/El Cajon
Days Inn by Wyndham San Diego-East/El Cajon
7.8 out of 10, Good, (1007)
The price is SAR 335
SAR 369 total
includes taxes & fees
10 Mar - 11 Mar

Best Western Plus La Mesa San Diego
Best Western Plus La Mesa San Diego
8.2 out of 10, Very Good, (1005)
The price is SAR 443
SAR 487 total
includes taxes & fees
16 Mar - 17 Mar

SpringHill Suites by Marriott Chula Vista Eastlake
SpringHill Suites by Marriott Chula Vista Eastlake
9.6 out of 10, Exceptional, (253)
The price is SAR 623
SAR 686 total
includes taxes & fees
30 Mar - 31 Mar

Ramada by Wyndham San Diego Poway Miramar
Ramada by Wyndham San Diego Poway Miramar
6.8 out of 10, (733)
The price is SAR 334
SAR 368 total
includes taxes & fees
9 Mar - 10 Mar

Sonesta ES Suites San Diego - Rancho Bernardo
Sonesta ES Suites San Diego - Rancho Bernardo
8.4 out of 10, Very Good, (965)
The price is SAR 484
SAR 545 total
includes taxes & fees
30 Mar - 31 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Serra Mesa
Where to stay in Serra Mesa
Hotels in top San Diego neighborhoods Learn more about Serra Mesa

Downtown San Diego
3 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
Recent reviews of Serra Mesa hotels
Recent reviews of Serra Mesa hotels

Handlery Hotel
5/5 Excellent
"Very comfortable, safe and clean. Has a resort feel. Did not like expensive daily parking fee.
"
A verified traveler stayed at Handlery Hotel
Posted 11 hours ago
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Serra Mesa Hotels by Star Rating
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