Find Resorts & Hotels with Spas in Sanibel, FL

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Pick from 300 Sanibel Resorts & Hotels with Spas and compare room rates, reviews, and availability. Most hotels are fully refundable.

Sanibel Island Beach Resort

3.0 star property
8.6 out of 10, Excellent, (1057)
"Nice people, clean place, felt very welcomed."
The price is SAR 972
SAR 1,156 total
includes taxes & fees
25 Nov - 26 Nov
Sanibel Island Beach Resort

Island Inn

3.5 star property
9.4 out of 10, Exceptional, (1061)
"Lovely place to stay! The management team was incredible, beautifully decorated very comfortable beds and extremely clean! Right on the beach❤️❤️❤️❤️"
The price is SAR 1,310
SAR 1,461 total
includes taxes & fees
9 Dec - 10 Dec
Island Inn

Tarpon Tale Inn

3.0 star property
9.6 out of 10, Exceptional, (375)
"A gem! Quaint property that makes your stay enjoyable. They have everything that you need for a day at the beach/shell seeking. The chairs, umbrella, shovels, buckets, towels, and wagon are there to use. Loved it! "
Tarpon Tale Inn

THE Palmview AND Sandpiper Inns

3.5 star property
9.4 out of 10, Exceptional, (145)
"We have stayed at the Palmview/Sandpiper three times over the last several years and look forward to coming back again next year. The property has been beautifully renovated since Hurricane Ian! We love that it is on a quiet street and within walking distance of the beach. "
THE Palmview AND Sandpiper Inns

Casa Ybel Resort

2.5 star property
8.8 out of 10, Excellent, (289)
"Both the staff and resort were wonderful. Very clean place. Staff at the hotel, restaurants and pool were all very sweet and helpful. Would highly recommend this resort for families as the units are spacious, have full kitchens, and an outdoor screened in porch. The only negative was that the beach chairs are not included in the stay. You would need to rent them daily or by the week or get your own beach chairs and umbrellas from a local shop and bring them to the beach. Even with that...
Casa Ybel Resort

Sanibel Home ready for rentals !

Sanibel Home ready for rentals !

FULLY RESTORED! Rare Walkout Condo On Sanibel Beach

10.0 out of 10, Exceptional, (82)
"We had a wonderful time at Breakers West. The condo was absolutely spotless. It was the only condo group that was occupied due to the recent storms. The shells were piled up 3-4 feet in some spots on the beach due to the storms. The Island is rebuilding but we found plenty of spots open for lunch and dinner. The condo was a very short walk to the beach and it had everything we needed for a week stay. We would highly recommend this property."
FULLY RESTORED! Rare Walkout Condo On Sanibel Beach

SANIBEL SUN CASTLE - Splendid home, great location, heated pool, bike to beach

9.8 out of 10, Exceptional, (88)
"Ralph was the most responsive and helpful host I have ever dealt with in all the years I have been using VRBO and other on line rental sites. Pool was great and view was amazing. Close to many things in Sanibel which of course is a great island and recovering from the storms but still has its charm."
SANIBEL SUN CASTLE - Splendid home, great location, heated pool, bike to beach

Stunning Luxury villa "Sandpiper" across the street from the beach!

9.2 out of 10, Wonderful, (31)
"Very short walk to a nice beach where the fishing was outstanding. Canal very handy in the back yard for a boat. Minimal furniture, for example nothing to set a suitcase on, but essentials were there. It was very clean and smelled fresh. The main bed was comfortable. We didn't use the twine."
The price is SAR 695
SAR 1,857 total
includes taxes & fees
7 Dec - 8 Dec
Stunning Luxury villa "Sandpiper" across the street from the beach!

Sanibel-Style on the East End! Walk to restaurants and the lighthouse. NEW!

9.8 out of 10, Exceptional, (37)
"Great place - thanks so much!"
The price is SAR 710
SAR 1,180 total
includes taxes & fees
26 Nov - 27 Nov
Sanibel-Style on the East End! Walk to restaurants and the lighthouse. NEW!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Sanibel?
Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Travelers love the beaches in Sanibel. Hotels with spas are a great way to break out of your daily routine and add a layer of luxury to your weekend away.
How many spa hotels will I find in Sanibel?
Among Expedia’s 922 accommodation options in Sanibel, there are 2 spa hotels.
What's there to see and do in Sanibel?
Enjoy Sanibel and visit Sanibel Island Northern Beach, Sanibel Island Lighthouse, and Periwinkle Way. If you have extra time while you’re in the area, you might want to see Sanibel Island Southern Beach and J. N. Ding Darling National Wildlife Refuge.
What is a Sanibel spa hotel?
Spa hotels in Sanibel provide lodging and have an on-site spa which offers services like couples massages as well as body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.