Find Luxury Hotels in Sanibel, FL

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Check availability on Sanibel Luxury Hotels

Compare Sanibel Luxury Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Frequently asked questions

Are you looking for a luxury hotel for your stay in Sanibel?
Use Expedia and let us help you arrange a flight to Southwest Florida Intl. Airport (RSW) airport or Punta Gorda Airport (PGD) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that Sanibel offers. During your visit, you might want to enjoy the beaches and sunsets which Sanibel is known for.
How many luxury hotels will I find in Sanibel?
Lie in the lap of luxury during your getaway to Sanibel in one of Expedia’s 6 luxury hotels.
When can I expect good weather in Sanibel?
Planning for the weather is an important factor for making your trip to Sanibel a success, especially when you’re splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 68°F. The rainiest months in Sanibel are August, September, July, and June, with each month seeing an average of 9 inches of rainfall.
What's there to see and do in Sanibel?
Enjoy all that Sanibel has to offer when you visit Sanibel Island Northern Beach, Sanibel Island Lighthouse, and Periwinkle Way. If you have a little extra time during your trip, you might want to check out Sanibel Island Southern Beach and J. N. Ding Darling National Wildlife Refuge.