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Compare 158 Vacation Homes in Byron with updated reviews, rates, and availability.

Century Cottage-PERFECT for Mayo & downtown visitors!

10.0 out of 10, Exceptional, (110)
"My wife, daughter, and I had a great stay at the Century Cottage this past weekend. The house is very conveniently located between downtown Rochester and the Rochester Recreation Center. It was less than a mile walk/drive to the recreation center and a short drive to downtown Rochester. Mary was also very responsive to any messages we sent. All questions were answered within minutes. We would definitely stay here again if we're ever back in the Rochester area."
Century Cottage-PERFECT for Mayo & downtown visitors!

Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown

10.0 out of 10, Exceptional, (32)
"This is a charming, incredibly well maintained and updated home, complete wirh absolutely everything any group or age could need. Extraordinarily clean, the location is convenient, but far enough away from the bustle of being right near Mayo Clinic. The adjustable bed was super comfortable as well."
Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown

1 mi. from Mayo Clinic; Cozy, Clean

9.6 out of 10, Exceptional, (89)
"Nice location. Comfortable beds. Overall very accommodating "
1 mi. from Mayo Clinic; Cozy, Clean

NEW Listing - Entertainment for the whole family. Sleeps up to 12.

10.0 out of 10, Exceptional, (2)
"Arrived at 4pm and the house was all ready for us. House was located in q quiet neighborhood. Pictures were an accurate description of the house. Communication with the owner was quick and smooth. House had a great floorplan and you could see from the front room all the way to the kitchen which was great when traveling with a toddler. Extra bonus points for the permanent gate at the top of the stairs. Kitchen was stocked with plenty of everything you would need plus quite the selection of...
NEW Listing - Entertainment for the whole family. Sleeps up to 12.

Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly

9.8 out of 10, Exceptional, (56)
"We had a group of coaches coming to Rochester for a gymnastics event. The house suited our needs perfectly. Great for a larger group of adults staying together. "
Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly

Fresh space near Mayo Clinic and downtown

9.4 out of 10, Exceptional, (18)
"Very clean property. It was comfortable and cute. The owners were responsive to us and so helpful"
Fresh space near Mayo Clinic and downtown

Magical Nest Hideaway

10.0 out of 10, Exceptional, (111)
"The wild turkeys and deer who greeted us in the morning. "
Magical Nest Hideaway

Luxury Stay/ Theater / Pool Table / Dogs Welcome

2.0 star property
10.0 out of 10, Exceptional, (5)
"We had the most lovely time talking and cooking and reconnecting with old friends. In fact we were so comfortable in this home we ordered in giving us more time to visit and play games. Thank you. Jennie"
Luxury Stay/ Theater / Pool Table / Dogs Welcome

2 Bedroom Apartment, Walk To Mayo, Free Parking

2.0 star property
The price is SAR 375
SAR 903 total
includes taxes & fees
21 Apr - 22 Apr
2 Bedroom Apartment, Walk To Mayo, Free Parking

Warm and cozy property<br>2 miles to Mayo and St. Mary’s. 4 bedrooms, 3 bathrooms.<br>

10.0 out of 10, Exceptional, (23)
"For us, it’s the perfect place to stay while attending medical visits at Mayo Clinic. Nice to come ‘home’, after a busy day, to a place that feels like home and has everything that we need."
Warm and cozy property<br>2 miles to Mayo and St. Mary’s. 4 bedrooms, 3 bathrooms.<br>

The Little House // Stylish & Cozy ~ 2 mi from Mayo Clinic

10.0 out of 10, Exceptional, (10)
"Ideal for travelers with pets "
The price is SAR 409
SAR 902 total
includes taxes & fees
31 Mar - 1 Apr
The Little House // Stylish & Cozy ~ 2 mi from Mayo Clinic

Charming 2-Bedroom house along city trail 1 mile from Mayo Clinic and downtown.

9.8 out of 10, Exceptional, (43)
"This is a wonderful house - great location, very clean, easy access to Mayo Clinic, shopping and restaurants. We will stay again. "
Charming 2-Bedroom house along city trail 1 mile from Mayo Clinic and downtown.

"Walden Pond" Adventure Amidst 44 Private Acres

10.0 out of 10, Exceptional, (123)
"Enjoyed our stay, good communication."
"Walden Pond" Adventure Amidst 44 Private Acres

Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.

10.0 out of 10, Exceptional, (72)
"Home was very clean and full of thoughtful details. Most necessary items were available in home. Very comfortable and location was great. Would definitely stay again. Thank you!! "
Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.

Newly remodeled "Beach" Themed home that is close to downtown and Mayo Clinic.

10.0 out of 10, Exceptional, (3)
"We were in Rochester for appointments at Mayo Clinic. Access to the Clinic was convenient. The house was clean and had everything we needed for our stay. We'll be back in March and plan to stay there again."
The price is SAR 274
SAR 734 total
includes taxes & fees
7 Apr - 8 Apr
Newly remodeled "Beach" Themed home that is close to downtown and Mayo Clinic.

☆Dee Dee's Den: A Dharma Dwellings Parent Company☆

10.0 out of 10, Exceptional, (31)
"We came to town to visit a family member at Mayo. The home was just as the listing stated. The house is beautiful and has so much room…more than we could even use. There were lots of supplies for us and we had everything we needed for a comfortable stay. We only needed to contact host about adjusting the temperature and he quickly responded and gave us guidance on that. I would absolutely stay here again and suggest it to others as well. Five stars! "
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆

Historic City Hall Recorder's Office - ADA Accessible

2.0 star property
10.0 out of 10, Exceptional, (7)
"Exactly as described, they were so accommodating, i was there for medical testing at Mayo and on the morning of checkbout a friend who traveled with me got sick and we needed to extend our syay for her to rest, they were quick to respond to messages and made the extension of stay super easy. Thank you so much for being great hosts! Ill be back when i return to mayo this is the only place i want to stay."
The price is SAR 356
SAR 877 total
includes taxes & fees
27 Apr - 28 Apr
Historic City Hall Recorder's Office - ADA Accessible

Silver Lake Oasis

9.6 out of 10, Exceptional, (34)
"We wanted a week to step back. This worked nicely. It has a gorgeous lake view and it's a short drive to many restaurants and shops."
Silver Lake Oasis

Discounted Charming 2-bedroom house in Rochester

10.0 out of 10, Exceptional, (1)
"Needed a last minute place to stay with my elderly parents for Mayo appointments. The home was clean, cute, location great, easy to find--very homey."
The price is SAR 338
SAR 829 total
includes taxes & fees
30 Mar - 31 Mar
Discounted Charming 2-bedroom house in Rochester

Charming 2 Bed 1 Bath Home W/Fully Fenced in Back yard

9.6 out of 10, Exceptional, (14)
"We were visiting Mayo Clinic & Hospital and traveling with our dog. This home was comfortable, perfectly located for our appointments, and the fenced in yard with a park across the street was what we needed for our canine companion. The owner was responsive to our questions and kindly allowed us extra days when we had to stay longer than planned. I would recommend this VRBO without hesitation."
The price is SAR 488
SAR 1,205 total
includes taxes & fees
10 Apr - 11 Apr
Charming 2 Bed 1 Bath Home W/Fully Fenced in Back yard
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Byron

The Berkman

3.0 star property
9.6 out of 10, Exceptional, (279)
"We have stayed at the Berkman several times and it's always been a wonderful experience!! The concierge service has always been so responsive and helpful, bringing us everything we need promptly! Our apartment is always very clean and comfortable. We always choose it when we are in Rochester!! "
The price is SAR 590
SAR 687 total
includes taxes & fees
15 Apr - 16 Apr
The Berkman

Century Cottage-PERFECT for Mayo & downtown visitors!

10.0 out of 10, Exceptional, (110)
"My wife, daughter, and I had a great stay at the Century Cottage this past weekend. The house is very conveniently located between downtown Rochester and the Rochester Recreation Center. It was less than a mile walk/drive to the recreation center and a short drive to downtown Rochester. Mary was also very responsive to any messages we sent. All questions were answered within minutes. We would definitely stay here again if we're ever back in the Rochester area."
Century Cottage-PERFECT for Mayo & downtown visitors!

Broadway Plaza, Trademark Collection by Wyndham

3.0 star property
9.2 out of 10, Wonderful, (149)
"Very good"
Broadway Plaza, Trademark Collection by Wyndham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.