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Compare 131 Vacation Homes in Byron with updated reviews, rates, and availability.

Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly
9.8 out of 10, Exceptional, (52)
"We had to gather a lot of family on short notice to say goodbye to a dying family member and this space was perfect for us all to gather and grieve together. There was plenty of sleeping space for everyone and it was conveniently lovlcated near parks and walking trails for our kiddos."
Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly
Fresh space near Mayo Clinic and downtown
9.6 out of 10, Exceptional, (16)
"Very clean property. It was comfortable and cute. The owners were responsive to us and so helpful"
Fresh space near Mayo Clinic and downtown
Single Level Living with Comfortable Recliners
10.0 out of 10, Exceptional, (29)
"This was our very first experience with a VRBO. It exceeded our expectations in every aspect including but not limited to the following: communicating with the property manager, cleanliness, kitchen supplies, bathroom accessories, up to date appliances, comfy recliners, easy instructions for TV/cable remotes… The host was responsive to short notice special requests we were in need of as well. This property definitely felt like “home away home”…good “vibes”. Quiet neighborhood with easy...
Single Level Living with Comfortable Recliners
Century Cottage-PERFECT for Mayo & downtown visitors!
10.0 out of 10, Exceptional, (101)
"We had a girls weekend and did some baking and shopping"
Century Cottage-PERFECT for Mayo & downtown visitors!
Delightful family home near pool, playground, park, nature center 1.6 mi to Mayo
10.0 out of 10, Exceptional, (23)
"A family member had several day appointments at the Mayo. He has mobility iaauws. Thia home eas perfect. 1 level. Walk-in shower. Bed with head and feet incline."
Delightful family home near pool, playground, park, nature center 1.6 mi to Mayo
2023 Construction, 5 BR, Gym, Game Area
10.0 out of 10, Exceptional, (14)
"The best luxurious home in Rochester MN "
2023 Construction, 5 BR, Gym, Game Area
Kutzky Cottage // 3 BR, 4 Blocks to Mayo, Family & Pet Friendly, Fenced Yard
10.0 out of 10, Exceptional, (8)
"Beautiful property. Very clean and well organized. Great space for our dog!"
Kutzky Cottage // 3 BR, 4 Blocks to Mayo, Family & Pet Friendly, Fenced Yard
City Hall Recorder's Office
2.0 star property
10.0 out of 10, Exceptional, (2)
"We were there for the Mayo experience. We walked pretty much every day. Only a 10 minute walk to most of the buildings. Lots of good food within walking distance too"
The price is SAR 263
SAR 757 total
includes taxes & fees
1 Dec - 2 Dec
City Hall Recorder's Office
"Walden Pond" Adventure Amidst 44 Private Acres
10.0 out of 10, Exceptional, (117)
"Really enjoyed the stay. It was very relaxing and a lot of fun"
"Walden Pond" Adventure Amidst 44 Private Acres
St. Augustine Mint House GARAGE!!
10.0 out of 10, Exceptional, (60)
"The St Augustine Mint House was so much more comfortable than a hotel would have been for our 3 day stay in Rochester. The one mile walk to Mayo was beautiful through the quiet neighborhood and across the the river on the nice days. On the rainy, windy, cold day, we made our way to the Civic Center (maybe just 1/2 mile), saw the Art Gallery there and then continued to the Clinic via the skyway system. The home was inviting, clean, tidy and comfortable. The kitchen was well equipped with makings...
St. Augustine Mint House GARAGE!!
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆
10.0 out of 10, Exceptional, (22)
"Every year my friends and family travel for a week. We are Combat Veterans, ranging from the Vietnam War to the Iraq and Afghanistan wars. This was the best house we have ever stayed in."
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆
Park in the Garage and Walk to Mayo Clinic
10.0 out of 10, Exceptional, (51)
"We loved our stay. It was quiet and comfortable and had everything we could have needed. Beds were great, kitchen was great. My husband loved the recliner to relax in between trips to the Mayo this week. Convenient, clean, and spacious. We appreciated a slightly later check out to accommodate the last appointment. Thanks for a great stay!"
Park in the Garage and Walk to Mayo Clinic
Great Family Home, Fenced Yard, Pet Friendly, 2 mi from Mayo
10.0 out of 10, Exceptional, (29)
"Perfect location for the wedding we were attending. House was clean and in a nice neighborhood. Primary bedroom did not have a king bed. Queen bed was okay but should be replaced due to the dip in the middle. "
Great Family Home, Fenced Yard, Pet Friendly, 2 mi from Mayo
Silver Lake Oasis
9.6 out of 10, Exceptional, (33)
"Cozy, mostly modern, except for the bathroom. Steep stairs to the bedroom. Love the location. Made a few casts from shore, but didn't catch any fish. Walk around to the lakefront a bit steep and unsteady. Otherwise, enjoyed our stay!"
Silver Lake Oasis
Charming Rochester Home - 2 Mi to Mayo Clinic!
9.8 out of 10, Exceptional, (14)
"The house is perfect for a larger family. It had all the amenities of home and we enjoyed the game room in the basement. The property managers were responsive and very helpful. Would 100% stay again if in the area."
Charming Rochester Home - 2 Mi to Mayo Clinic!
3 blk St Mary 11 Mayo Pet Friendly Covered ByFaith
9.6 out of 10, Exceptional, (22)
"The location is very central to Mayo and shopping. The neighborhood was quiet. I will stay there again."
The price is SAR 285
SAR 885 total
includes taxes & fees
17 Nov - 18 Nov
3 blk St Mary 11 Mayo Pet Friendly Covered ByFaith
Charming 2 Bed 1 Bath Home W/Fully Fenced in Back yard
9.4 out of 10, Exceptional, (11)
"Perfect size and proximity to Mayo Clinic and walking trails along the river. Would stay there agsin."
The price is SAR 357
SAR 1,038 total
includes taxes & fees
17 Nov - 18 Nov
Charming 2 Bed 1 Bath Home W/Fully Fenced in Back yard
Next to Mayo Clinic 518A
9.6 out of 10, Exceptional, (18)
"This property was very clean and had everything we needed for our stay. It was located close to Mayo which made it convenient to walk to the clinic. I give this place a 10 rating would stay here again."
Next to Mayo Clinic 518A
2 Blks St Marys Main Fl Beds Bath CoveredByFaith
10.0 out of 10, Exceptional, (91)
"The location was great for my heart procedure at St. Mary's, so convenient. the kitchen was also helpful for meals and the house was really comfortable. We're seniors so we did use the rubber bath mat in the tub for showers to be on the safe side. Having the laundry was a plus for us. It was close to a great family restaurant across the street from St. Mary's. Jessica was so kind when we needed a later check out on the day I was released from the hospital. It is a good place to stay for sure."
The price is SAR 398
SAR 1,038 total
includes taxes & fees
1 Dec - 2 Dec
2 Blks St Marys Main Fl Beds Bath CoveredByFaith
Updated 2+bedroom, 2 bath walk to Mayo Clinic
9.4 out of 10, Exceptional, (16)
"Roomy and comfortable with 2 full baths downstairs. Bonus with washer and dryer. Good location and quiet neighborhood."
Updated 2+bedroom, 2 bath walk to Mayo Clinic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Byron

Kahler Grand Hotel
3.0 star property
8.2 out of 10, Very Good, (1172)
"Very convenient to Mayo Clinic and comfortable room at reasonable price. Have stayed at this hotel 10 years and always good stay. "
The price is SAR 560
SAR 644 total
includes taxes & fees
21 Nov - 22 Nov
Kahler Grand Hotel
EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
4.0 star property
9.4 out of 10, Exceptional, (739)
"Lousy parking garage design. Dead ended rows, that if full are difficult to turn around in. Inadequate number parking spaces for the number of hotel rooms. No exit signage to show the driver how to drive out of the garage. Only exit signs are at the ends of dead end rows, and only for people on foot."
The price is SAR 436
SAR 552 total
includes taxes & fees
28 Nov - 29 Nov
EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
Hyatt House Rochester/Mayo Clinic Area
3.0 star property
9.2 out of 10, Wonderful, (744)
"Very quiet and convenient to walk to all the appointments at the Mayo Clinic. "
The price is SAR 391
SAR 450 total
includes taxes & fees
28 Nov - 29 Nov
Hyatt House Rochester/Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.