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Compare 143 Vacation Homes in Southeast Missouri with updated reviews, rates, and availability.

Quaint, Beautiful Home next to SEMO and Hospital

9.8 out of 10, Exceptional, (28)
"The property was fantastic!!! We loved the cozy fireplace! The location was wonderful, only five minutes from everything we were doing. The host was very easy to communicate with. "
Quaint, Beautiful Home next to SEMO and Hospital

Gabouri Place ~ Completely Renovated Victorian in Ste. Genevieve's Historic Dist

10.0 out of 10, Exceptional, (164)
"Nice location, clean and inviting."
Gabouri Place ~ Completely Renovated Victorian in Ste. Genevieve's Historic Dist

Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!

10.0 out of 10, Exceptional, (60)
"We chose this property for our 1st Christmas away from home. I traveled with my husband, 3 kids aged 10-17, and 2 dogs. Walking in the first thing we saw was the beautiful Christmas tree and the decorated screened in porch. The home was very clean and had everything we could possibly need. The furniture was comfy and there were plenty of places for everyone to sit and relax. The bedrooms were spacious. The closets provided more than enough space to hang the clothes we brought with us. These...
Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!

Whole house, secluded getaway near Alley Springs, Eminence , Missouri.

10.0 out of 10, Exceptional, (2)
"This location was a perfect place for a large family gathering. There was adequate space for a couple of families to stay overnight! Close to Harvey’s canoe/raft rentals! The host was very helpful!"
Whole house, secluded getaway near Alley Springs, Eminence , Missouri.

Cozy 1.5 story bungalow in downtown Ste. Genevieve!

9.8 out of 10, Exceptional, (11)
"My husband and I enjoyed the wineries then stayed at the house for one night. It was perfect for a little weekend getaway!"
The price is SAR 334
SAR 504 total
includes taxes & fees
2 Feb - 3 Feb
Cozy 1.5 story bungalow in downtown Ste. Genevieve!

Come stay at The White House. Old World Charm in fabulous Farmington

2.0 star property
9.8 out of 10, Exceptional, (8)
"We stayed here for 1 week and had a wonderful time. The home is convenient to stores and is a very family friendly home and area to stay. "
The price is SAR 488
SAR 975 total
includes taxes & fees
1 Feb - 2 Feb
Come stay at The White House. Old World Charm in fabulous Farmington

The Cabin on Current River with Private Gravel Bar!!

8.6 out of 10, Excellent, (25)
"Due to a situation beyond the property owners control we weren’t able to stay at the original cabin but they acted quickly and moved us to another. Great service and we had a great time. "
The Cabin on Current River with Private Gravel Bar!!

Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE

10.0 out of 10, Exceptional, (59)
"Nice farmhouse in the country."
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE

Missouri Castle w/ Private Lake, Pool & 100 Acres!

10.0 out of 10, Exceptional, (3)
"My family of 14 people needed a place for all of us to stay for the holidays. The twin turrets was a great fit for what we needed. Everyone had their own bed, the bathrooms took a little time to get showers scheduled, since there are only 2 showers, but it worked out. The home was fun to explore inside and out. We went for some walks on the trails, enjoyed watching the ducks and geese, or just looking out at the lake. So peaceful! "
Missouri Castle w/ Private Lake, Pool & 100 Acres!

Tiny Houses of French Village

2.5 star property
10.0 out of 10, Exceptional, (2)
"Charming property with a space for everything and everything in its place. Would not hesitate to recommend or stay again."
The price is SAR 927
SAR 1,372 total
includes taxes & fees
28 Jan - 29 Jan
Tiny Houses of French Village

2 Bedroom Home less than 2 miles to Jacks Fork River

10.0 out of 10, Exceptional, (18)
"Thank you for sharing your beautiful home! Everything about it was perfect. We loved the fur mattresses and the quiet secluded yard. Everything was so clean. Everything we needed was there. Thank you;we would highly recommend!"
2 Bedroom Home less than 2 miles to Jacks Fork River

Black River Retreat 5 Minutes from Jeff’s Canoe Rental /K Bridge

10.0 out of 10, Exceptional, (12)
"Great accommodations for a family, lots of room. No wifi, tho."
Black River Retreat 5 Minutes from Jeff’s Canoe Rental /K Bridge

"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

10.0 out of 10, Exceptional, (11)
"Chip, thanks for our stay in your beautiful house. We had a wonderful Christmas visit thanks to you."
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

10.0 out of 10, Exceptional, (5)
"A large and comfortable house with cool historical details and just about everything you need to have a great, easy, smooth-running vacation. Great location for downtown exploring."
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

Sunshine Shack at Clearwater Lake (sleeps 6)

8.8 out of 10, Excellent, (10)
"Loved staying a week at Sunshine Shack. The screened in deck is perfect to watch the deer at dusk."
Sunshine Shack at Clearwater Lake (sleeps 6)

Historic Victorian close to amazing hiking - pet friendly!

9.0 out of 10, Wonderful, (2)
"Cute & clean home! Property manager was so easy to communicate with and super friendly!! We will be coming back!!"
The price is SAR 289
SAR 514 total
includes taxes & fees
29 Jan - 30 Jan
Historic Victorian close to amazing hiking - pet friendly!

Ste Genevieve Home on 17 Acres, Near Wineries!

9.8 out of 10, Exceptional, (7)
"We stayed at this property for my birthday weekend and it was fabulous! We cooked several meals and the kitchen had EVERYTHING! The house is nestled in the woods, with beautiful surroundings and the house is so cozy. I would definitely stay here again!"
Ste Genevieve Home on 17 Acres, Near Wineries!

Just A Stone's Throw Cabin from Eminence, Jacks Fork, & Cross County Trail Ride

9.0 out of 10, Wonderful, (10)
"It was nice to be able to pull right up to the entrance of the property and walk through the door with no stairs. For a one bedroom one bathroom apartment everything was very spacious and accommodating. We especially picked this because of the king size bed. We were not able to utilize some of the outdoor space, but I imagine it would be really nice to do so. We did however enjoy the wonderful gliders /on the front porch. The owner did a great job on the decor and the furniture is very...
The price is SAR 525
SAR 754 total
includes taxes & fees
31 Jan - 1 Feb
Just A Stone's Throw Cabin from Eminence, Jacks Fork, & Cross County Trail Ride

Rustic Lodge for 14 near Current River on private 35 acres

10.0 out of 10, Exceptional, (15)
"We stayed here with 2 other families and it’s great! The house has plenty of beds and bathrooms, is very clean and has an awesome space to eat together with a full kitchen. The outside is great with a pond to fish, use the paddle boat and paddle board. The locations was about 20 minutes away where we could float for the day. We would definitely recommend and will be coming back! "
The price is SAR 1,272
SAR 2,385 total
includes taxes & fees
29 Jan - 30 Jan
Rustic Lodge for 14 near Current River on private 35 acres

RIVER FRONT HOUSE

9.6 out of 10, Exceptional, (38)
"Nice place. Would stay again."
RIVER FRONT HOUSE
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Southeast Missouri

Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel

3.5 star property
9.4 out of 10, Exceptional, (139)
"Many things to do if you don't want to go anywhere. Close to shopping, restaurant. "
The price is SAR 596
SAR 687 total
includes taxes & fees
28 Jan - 29 Jan
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel

Postcard Cabins St. Francois

2.0 star property
The price is SAR 300
SAR 323 total
includes taxes & fees
3 Feb - 4 Feb
Postcard Cabins St. Francois

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

9.8 out of 10, Exceptional, (31)
"Beautiful place very unique the only thing i didnt like was the parking"
The price is SAR 341
SAR 555 total
includes taxes & fees
2 Feb - 3 Feb
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.