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Compare 172 Vacation Homes in Southeast Missouri with updated reviews, rates, and availability.

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (128)
"We had a wonderful time at Serenity South! The house is quiet and very clean, in walking distance of fantastic shops and fun places to eat. We look forward to returning next year!"
The price is SAR 563
SAR 919 total
includes taxes & fees
30 Mar - 31 Mar
Serenity South -- Gardens, River-Views, and Refreshing Space

The Sutton House 2 blocks from Main Street & Courthouse Square

10.0 out of 10, Exceptional, (20)
"This was a great option if you’re staying in the area. Great communication with the owner, all the appointments you need. Great (very very small) town but again all you need. Be sure to get coffee from Acadia and Mexican at el Checo’s. Only thing I’d note is the upstairs bathroom is bathtub only which is clearly called out in the description but just want to be sure folks saw that. Highly recommended if you’re needing a great place in Ironton. "
The price is SAR 510
SAR 662 total
includes taxes & fees
2 Apr - 3 Apr
The Sutton House 2 blocks from Main Street & Courthouse Square

"Little Brick House on Main (1865)”

10.0 out of 10, Exceptional, (39)
"We were there for our grandson's wedding. This little house exceeded all expectation. Just lovely and with so many extra thoughtful touches, i.e. pumpkins and fall flowers for cozy October. Too many to list. "
The price is SAR 495
SAR 645 total
includes taxes & fees
2 Apr - 3 Apr
"Little Brick House on Main (1865)”

Cozy Three bedroom home in Central Farmington

9.6 out of 10, Exceptional, (18)
"This house was a home!! Decorated for Christmas including a tree!! Nice blankets in the living room to cuddle up with plus an electric fireplace!! Loved every minute of it. Host has it well stocked with coffee supplies, shower soaps and shampoo best of all laundry doap and dryer sheets"
The price is SAR 450
SAR 970 total
includes taxes & fees
30 Mar - 31 Mar
Cozy Three bedroom home in Central Farmington

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

8.8 out of 10, Excellent, (27)
"Amazing property that we simply didn't stay long enough to enjoy in its completeness. Billiards and Putt-Putt on entry, so attractive that we started playing before we even unpacked! I'm very artsy interior, and lots of room and outdoor fire pit, multiple decks, and an in-ground pool. The home is even on the grounds, an event venue. Probably a wonderful combination for them! Would enjoy returning, but for a longer stay will you could enjoy all with the property had to offer! Highly recommend it"
The price is SAR 563
SAR 876 total
includes taxes & fees
7 Apr - 8 Apr
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!

10.0 out of 10, Exceptional, (60)
"We chose this property for our 1st Christmas away from home. I traveled with my husband, 3 kids aged 10-17, and 2 dogs. Walking in the first thing we saw was the beautiful Christmas tree and the decorated screened in porch. The home was very clean and had everything we could possibly need. The furniture was comfy and there were plenty of places for everyone to sit and relax. The bedrooms were spacious. The closets provided more than enough space to hang the clothes we brought with us. These...
Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

The price is SAR 1,122
SAR 1,775 total
includes taxes & fees
7 Apr - 8 Apr
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

Wren’s Hideaway Sleeps 8 Historic downtown neighborhood Charming & Relaxing

10.0 out of 10, Exceptional, (18)
"We were there for a family funeral. There was virtual nothing wrong with the home. I am persnickety do I did notice a spot on the hallway floor. My sister did not. I didn’t check it or try to clean it. I just went in with the events of the day. We had tornado warnings and there were zero issues. Again, I don’t think we can say enough regarding the graciousness of our hosts. I would highly recommend this home. "
Wren’s Hideaway Sleeps 8 Historic downtown neighborhood Charming & Relaxing

Whole house, secluded getaway near Alley Springs, Eminence , Missouri.

10.0 out of 10, Exceptional, (2)
"This location was a perfect place for a large family gathering. There was adequate space for a couple of families to stay overnight! Close to Harvey’s canoe/raft rentals! The host was very helpful!"
Whole house, secluded getaway near Alley Springs, Eminence , Missouri.

Dexter Homestead. Very Cozy & NEW Remodel !

8.0 out of 10, Very Good, (22)
"Plenty of room to move about. Quiet neighborhood. Host took care of all our needs."
The price is SAR 371
SAR 762 total
includes taxes & fees
7 Apr - 8 Apr
Dexter Homestead. Very Cozy & NEW Remodel !

Pet-Friendly Downtown Ironton minutes away Elephant Rocks, Johnson Shut-ins

10.0 out of 10, Exceptional, (25)
"Very friendly, helpful host, clean and cute house. Love the area for shops, and hiking we had a wonderful stay!"
The price is SAR 491
SAR 885 total
includes taxes & fees
30 Mar - 31 Mar
Pet-Friendly Downtown Ironton minutes away Elephant Rocks, Johnson Shut-ins

Newly remodeled house close to downtown and minutes away from golf courses

2.0 star property
10.0 out of 10, Exceptional, (12)
"Our family of 5 stayed here while visiting relatives. The house is clean and comfortable. Lots of extra touches—a whole closet full of towels, coffee pods supplies for our stay, basement full with of entertainment, a cozy electric fireplace, and streaming options on TV. The bedrooms were spacious. "
The price is SAR 368
SAR 715 total
includes taxes & fees
30 Mar - 31 Mar
Newly remodeled house close to downtown and minutes away from golf courses

Cute town house -3 Queen beds

10.0 out of 10, Exceptional, (11)
"Clean house"
Cute town house -3 Queen beds

Private lake, beach & hot tub, romantic getaway or family vaca

10.0 out of 10, Exceptional, (23)
"We had a funeral in Poplar Bluff and needed a place to stay. This worked well for our family for the few days we stayed. "
Private lake, beach & hot tub, romantic getaway or family vaca

Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE

10.0 out of 10, Exceptional, (59)
"Nice farmhouse in the country."
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE

Unbeatable convenience in amazing Eminence!

Unbeatable convenience in amazing Eminence!

'The Lakehouse' Lovely Wappapello Country Home!

9.6 out of 10, Exceptional, (15)
"This place worked out perfect for our group of snow goose hunters."
'The Lakehouse' Lovely Wappapello Country Home!

Charming 2-bedroom house in delightful Jackson with AC, WiFi

10.0 out of 10, Exceptional, (3)
"We had 4 of us for a 2 night stay. The property is clean, everything looked fresh and welcoming. The house is located about a mile off of hwy 61, so is close to fuel, restaurants, etc. We enjoyed the quiet surroundings."
Charming 2-bedroom house in delightful Jackson with AC, WiFi

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

10.0 out of 10, Exceptional, (5)
"A large and comfortable house with cool historical details and just about everything you need to have a great, easy, smooth-running vacation. Great location for downtown exploring."
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

Historic Victorian close to amazing hiking - pet friendly!

9.0 out of 10, Wonderful, (4)
"Convenient to everything in Fredericktown. "
Historic Victorian close to amazing hiking - pet friendly!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Southeast Missouri

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG

3.5 star property
9.4 out of 10, Exceptional, (139)
"Many things to do if you don't want to go anywhere. Close to shopping, restaurant. "
The price is SAR 596
SAR 687 total
includes taxes & fees
31 Mar - 1 Apr
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (3)
"This place made me look like a rockstar to my wife. I surprised her with a V day getaway. The cabin was awesome. We loved the view of nature from the large window. I made dinner reservations nearby at the weingarten vineyard. The hiking trail along the creek was fun. We ate breakfast right down the road at Kozy. For our final night I cooked steaks over the open fire"
The price is SAR 338
SAR 363 total
includes taxes & fees
13 Apr - 14 Apr
Postcard Cabins St. Francois

River front property HOT TUB, Kayak, tubing, and fishing

9.6 out of 10, Exceptional, (83)
"This is a super low key place with great access to the river."
The price is SAR 634
SAR 1,021 total
includes taxes & fees
30 Mar - 31 Mar
River front property HOT TUB, Kayak, tubing, and fishing
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.