Search Vacation Homes in Southeast Missouri

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Check prices for these dates

Next weekend
25 Rab. II - 27 Rab. II
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2 Jum. I - 4 Jum. I
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16 Jum. I - 18 Jum. I
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13 Jum. II - 15 Jum. II

Compare 172 Vacation Homes in Southeast Missouri with updated reviews, rates, and availability.

Serenity South -- Gardens, River-Views, and Refreshing Space
Fridge, microwave, oven, stovetop

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (130)
"When looking for a VRBO for our daughter's college visit, we knew the perfect place to stay! This is our second stay at Serenity South and it was just as incredible as the first visit. Clean, inviting and cozy. Thanks Jo for another beautiful stay."
The price is SAR 563
SAR 919 total
includes taxes & fees
22 Apr - 23 Apr
Serenity South -- Gardens, River-Views, and Refreshing Space
The Sutton House 2 blocks from Main Street & Courthouse Square
Exterior

The Sutton House 2 blocks from Main Street & Courthouse Square

10.0 out of 10, Exceptional, (22)
"Beautiful stately home in peaceful neighborhood close to Elephant Rock and Johnston Shut Ins. Highly recommended! "
The price is SAR 638
SAR 824 total
includes taxes & fees
24 Apr - 25 Apr
The Sutton House 2 blocks from Main Street & Courthouse Square
"Little Brick House on Main (1865)”
Interior

"Little Brick House on Main (1865)”

10.0 out of 10, Exceptional, (41)
"Nostalgic quaint place in a central location. "
The price is SAR 495
SAR 645 total
includes taxes & fees
24 Apr - 25 Apr
"Little Brick House on Main (1865)”
Cozy Three bedroom home in Central Farmington
Fridge, microwave, oven, stovetop

Cozy Three bedroom home in Central Farmington

9.6 out of 10, Exceptional, (21)
"A very nice little house clean had everything we need and the manager was very nice"
The price is SAR 450
SAR 970 total
includes taxes & fees
22 Apr - 23 Apr
Cozy Three bedroom home in Central Farmington
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Exterior

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

8.8 out of 10, Excellent, (28)
"all was so nice and we enjoyed our stay. grandkids and us loved having pool table and card games and all the peace and quiet there. thank u again for contacting me and giving us address. we appreciated that very much. "
The price is SAR 563
SAR 880 total
includes taxes & fees
22 Apr - 23 Apr
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!
Miscellaneous

Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!

10.0 out of 10, Exceptional, (60)
"We chose this property for our 1st Christmas away from home. I traveled with my husband, 3 kids aged 10-17, and 2 dogs. Walking in the first thing we saw was the beautiful Christmas tree and the decorated screened in porch. The home was very clean and had everything we could possibly need. The furniture was comfy and there were plenty of places for everyone to sit and relax. The bedrooms were spacious. The closets provided more than enough space to hang the clothes we brought with us. These...
Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Exterior

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

8.0 out of 10, Very Good, (1)
"The house has a very eclectic decor, but fun. We were a group of 10 ladies and had a great time. Thank you "
The price is SAR 1,122
SAR 1,776 total
includes taxes & fees
22 Apr - 23 Apr
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Wren’s Hideaway Sleeps 8 Historic downtown neighborhood Charming & Relaxing
Exterior

Wren’s Hideaway Sleeps 8 Historic downtown neighborhood Charming & Relaxing

10.0 out of 10, Exceptional, (19)
"Great accommodations, close to everything, very clean updated and comfortable. We enjoyed walking downtown for the 4 th Friday art walk and quaint shops. The house had everything we needed. We enjoyed sitting around fire pit in evening and on the porch in the morning. Would def book again!"
Wren’s Hideaway Sleeps 8 Historic downtown neighborhood Charming & Relaxing
Whole house, secluded getaway near Alley Springs, Eminence , Missouri.
Exterior

Whole house, secluded getaway near Alley Springs, Eminence , Missouri.

10.0 out of 10, Exceptional, (2)
"This location was a perfect place for a large family gathering. There was adequate space for a couple of families to stay overnight! Close to Harvey’s canoe/raft rentals! The host was very helpful!"
Whole house, secluded getaway near Alley Springs, Eminence , Missouri.
Dexter Homestead. Very Cozy & NEW Remodel !
Smart TV, fireplace, stereo

Dexter Homestead. Very Cozy & NEW Remodel !

8.0 out of 10, Very Good, (23)
"Plenty of room to move about. Quiet neighborhood. Host took care of all our needs."
The price is SAR 371
SAR 770 total
includes taxes & fees
22 Apr - 23 Apr
Dexter Homestead. Very Cozy & NEW Remodel !
Pet-Friendly Downtown Ironton minutes away Elephant Rocks, Johnson Shut-ins
Property grounds

Pet-Friendly Downtown Ironton minutes away Elephant Rocks, Johnson Shut-ins

10.0 out of 10, Exceptional, (28)
"Our family of 4 stayed two nights so we could hike Elephant Rocks and Johnson's Shut-Ins. Cute little house, with everything we needed for a pleasant stay. Had warm weather and really enjoyed the Adirondack chairs on the front porch for morning coffee. We did discovered that being in town in March, Tuesday-Thursday, meant many businesses were not open. Checo's Mexican, Arcadia Valley Coffee, and the The Iron Mule were all delightful, and we are food/coffee snobs from Chicago :-)"
The price is SAR 469
SAR 859 total
includes taxes & fees
22 Apr - 23 Apr
Pet-Friendly Downtown Ironton minutes away Elephant Rocks, Johnson Shut-ins
Newly remodeled house close to downtown and minutes away from golf courses
Terrace/patio

Newly remodeled house close to downtown and minutes away from golf courses

2.0 star property
10.0 out of 10, Exceptional, (14)
"Not only was this in a very convenient location for our stay, but the downstairs area has a great game room that we didn’t originally see on the description. Plenty of bedrooms and little extras that were very thoughtful. Things like USB plug-ins and a heated blanket and plenty of towels and dishes."
The price is SAR 368
SAR 711 total
includes taxes & fees
27 Apr - 28 Apr
Newly remodeled house close to downtown and minutes away from golf courses
Cute town house with fenced backyard
Fridge, microwave, oven, stovetop

Cute town house with fenced backyard

9.8 out of 10, Exceptional, (12)
"Clean house"
The price is SAR 394
SAR 739 total
includes taxes & fees
28 Apr - 29 Apr
Cute town house with fenced backyard
Private lake, beach & hot tub, romantic getaway or family vaca
Private kitchen

Private lake, beach & hot tub, romantic getaway or family vaca

10.0 out of 10, Exceptional, (23)
"We had a funeral in Poplar Bluff and needed a place to stay. This worked well for our family for the few days we stayed. "
Private lake, beach & hot tub, romantic getaway or family vaca
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
Outdoor pool

Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE

10.0 out of 10, Exceptional, (59)
"Nice farmhouse in the country."
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
Unbeatable convenience in amazing Eminence!
Private kitchen

Unbeatable convenience in amazing Eminence!

Unbeatable convenience in amazing Eminence!
'The Lakehouse' Lovely Wappapello Country Home!
Miscellaneous

'The Lakehouse' Lovely Wappapello Country Home!

9.8 out of 10, Exceptional, (16)
"Traveled with my two daughters (teens) to visit my mom. The house was perfect for hanging around and visiting with family. Well stocked and good communication from the host. "
'The Lakehouse' Lovely Wappapello Country Home!
Charming 2-bedroom house in delightful Jackson with AC, WiFi
Fridge, microwave, oven, stovetop

Charming 2-bedroom house in delightful Jackson with AC, WiFi

10.0 out of 10, Exceptional, (3)
"We had 4 of us for a 2 night stay. The property is clean, everything looked fresh and welcoming. The house is located about a mile off of hwy 61, so is close to fuel, restaurants, etc. We enjoyed the quiet surroundings."
Charming 2-bedroom house in delightful Jackson with AC, WiFi
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
Fridge, microwave, oven, stovetop

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

10.0 out of 10, Exceptional, (5)
"A large and comfortable house with cool historical details and just about everything you need to have a great, easy, smooth-running vacation. Great location for downtown exploring."
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
Historic Victorian close to amazing hiking - pet friendly!
Interior

Historic Victorian close to amazing hiking - pet friendly!

8.8 out of 10, Excellent, (6)
"Comfortable"
Historic Victorian close to amazing hiking - pet friendly!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Southeast Missouri

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Exterior

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG

3.5 star property
9.4 out of 10, Exceptional, (140)
"Beautiful property. Lots to do with the kids. Would be happy to come back when I have more time to spend there. "
The price is SAR 597
SAR 688 total
includes taxes & fees
28 Apr - 29 Apr
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Postcard Cabins St. Francois
Terrace/patio

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (3)
"This place made me look like a rockstar to my wife. I surprised her with a V day getaway. The cabin was awesome. We loved the view of nature from the large window. I made dinner reservations nearby at the weingarten vineyard. The hiking trail along the creek was fun. We ate breakfast right down the road at Kozy. For our final night I cooked steaks over the open fire"
The price is SAR 338
SAR 505 total
includes taxes & fees
4 May - 5 May
Postcard Cabins St. Francois
Springside Cottage in beautiful Eminence. Great outdoor space - NEW Hot tub!
Fridge, microwave, oven, stovetop

Springside Cottage in beautiful Eminence. Great outdoor space - NEW Hot tub!

10.0 out of 10, Exceptional, (2)
"My fiancè and I had a lovely time staying at this cute little cottage. The location is perfect. It's tucked away but close enough to all there is to see and do in Eminence. The hot tub in the patio with the tv was so cool. I definitely would stay here again!"
The price is SAR 713
SAR 841 total
includes taxes & fees
22 Apr - 23 Apr
Springside Cottage in beautiful Eminence. Great outdoor space - NEW Hot tub!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.