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Compare 408 Vacation Homes in Southern Minnesota with updated reviews, rates, and availability.

Rustic Retreat 2 blocks from Mayo Hospital and Bethany College.
Rustic Retreat 2 blocks from Mayo Hospital and Bethany College.
10.0 out of 10, Exceptional, (1)
The price is SAR 371
SAR 495 total
includes taxes & fees
18 Mar - 19 Mar

1 mi. from Mayo Clinic; Cozy, Clean
1 mi. from Mayo Clinic; Cozy, Clean
9.6 out of 10, Exceptional, (88)

NEW Listing - Entertainment for the whole family. Sleeps up to 12.
NEW Listing - Entertainment for the whole family. Sleeps up to 12.
10.0 out of 10, Exceptional, (1)

Century Cottage-PERFECT for Mayo & downtown visitors!
Century Cottage-PERFECT for Mayo & downtown visitors!
10.0 out of 10, Exceptional, (109)

Villa Del Lago - Lakehouse on Lake Pepin
Villa Del Lago - Lakehouse on Lake Pepin
10.0 out of 10, Exceptional, (134)

☆Dee Dee's Den: A Dharma Dwellings Parent Company☆
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆
10.0 out of 10, Exceptional, (31)

Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown
Delightful family home near parks, nature center, 1.5 m to Mayo Clinic downtown
10.0 out of 10, Exceptional, (31)

Quiet and convenient home with a view
Quiet and convenient home with a view
10.0 out of 10, Exceptional, (15)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Southern Minnesota

The Berkman
The Berkman
9.6 out of 10, Exceptional, (275)
The price is SAR 446
SAR 518 total
includes taxes & fees
21 Mar - 22 Mar

Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!
Sunrise on Skyline - Indoor Pool - Arcades - Amazing Views!
10.0 out of 10, Exceptional, (66)

Log Inn on Madison Lake. Multi generation. Corporate retreat for team building
Log Inn on Madison Lake. Multi generation. Corporate retreat for team building
10.0 out of 10, Exceptional, (107)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent reviews of Southern Minnesota hotels
Recent reviews of Southern Minnesota hotels

Staybridge Suites Rochester - Mayo Clinic Area by IHG
5/5 Excellent
One of favorite places to stay in Rochester!
"Check-in and out was amazingly simple. The breakfast was open earlier than posted each morning, which was amazing because we had to be out of the hotel early for wrestling weigh-ins and my kids were able to grab a couple of things to take for breakfast. The hotel was quiet at night and the staff are so friendly every time we stay. "
A verified traveler stayed at Staybridge Suites Rochester - Mayo Clinic Area by IHG
Posted 10 hours ago
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