Photo by Cindy Keese
Find hotels in Seneca, SC from SAR 209
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Go beyond your typical stay in Seneca
Pet friendly
Cabin
Check prices for these dates
Tonight
Tomorrow
This weekend
Next weekend
Compare 1,525 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Lakeside Lodge Clemson
Lakeside Lodge Clemson
9.0 out of 10, Wonderful, (861)
The price is SAR 409
SAR 504 total
includes taxes & fees
11 May - 12 May

Hampton Inn & Suites Seneca-Clemson Area
Hampton Inn & Suites Seneca-Clemson Area
9.4 out of 10, Exceptional, (592)
The price is SAR 459
SAR 505 total
includes taxes & fees
1 Jun - 2 Jun

Tru by Hilton Seneca Clemson
Tru by Hilton Seneca Clemson
9.2 out of 10, Wonderful, (712)
The price is SAR 379
SAR 417 total
includes taxes & fees
25 May - 26 May

Quality Inn Seneca US-123
Quality Inn Seneca US-123
8.0 out of 10, Very Good, (586)
The price is SAR 312
SAR 381 total
includes taxes & fees
26 May - 27 May

Best Western Seneca-Clemson
Best Western Seneca-Clemson
8.4 out of 10, Very Good, (585)
The price is SAR 367
SAR 403 total
includes taxes & fees
20 May - 21 May

Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ Area
9.4 out of 10, Exceptional, (146)
The price is SAR 484
SAR 532 total
includes taxes & fees
13 May - 14 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Learn more about Seneca
Escape to Seneca! Enjoy its sports, lake views, and coffee.

Photo by Cindy Keese
Open Photo by Cindy Keese
Where to stay in Seneca
Where to stay in Seneca
Find the best Seneca areas and neighborhoods for the activities you enjoy most. Learn more about Seneca

Serenity Bay
Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee.
More cheap stays in Seneca
More cheap stays in Seneca

Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd, Clemson, SC
The price is SAR 364 per night from May 11 to May 12
SAR 364
SAR 403 total
includes taxes & fees
11 May - 12 May
8.2/10 Very Good! (1,000 reviews)
Hotels in Seneca with star-rating
Hotels in Seneca with star-rating

4 Star Hotels
8 properties
Stay near popular Seneca attractions
Stay near popular Seneca attractions
Recent reviews of Seneca hotels
Recent reviews of Seneca hotels

4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake.
5/5 Excellent
Great decks!
"Wonderful lake house inside and out.Beautiful landscaping. Even on a rainy day, the generous covered deck with lots of seating allows outdoor time."
A verified traveler stayed at 4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake.
Posted 3 days ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in Seneca Neighborhoods
More Hotel Options in Seneca
- Adventure Hotels in Seneca
- Beach Hotels in Seneca
- Business Hotels in Seneca
- Cheap Hotels in Seneca
- Family Hotels in Seneca
- Golf Hotels in Seneca
- Historic Hotels in Seneca
- Hotel Wedding Venues in Seneca
- Hotels with Bars in Seneca
- Hotels with Free Parking in Seneca
- Hotels with Hot Tubs in Seneca
- Hotels with WiFi in Seneca
- Hotels with a Pool in Seneca
- Hotels with smoking rooms in Seneca
- Luxury Hotels in Seneca
- Pet-friendly Hotels in Seneca
- Resorts & Hotels with Spas in Seneca
- Romantic Hotels in Seneca
- Shopping Hotels in Seneca
- Ski Hotels in Seneca
Seneca Hotels by Brand
Other Hotels near Seneca, South Carolina
- Highlands Hotels
- Brevard Hotels
- Clemson Hotels
- Anderson Hotels
- North Carolina Mountains Hotels
- Cashiers Hotels
- Blue Ridge Mountains Hotels
- Clayton Hotels
- Sapphire Hotels
- Lake Toxaway Hotels
- Salem Hotels
- Clarkesville Hotels
- Easley Hotels
- Toccoa Hotels
- Central Hotels
- Hartwell Hotels
- Dillard Hotels
- Mountain Rest Hotels
- Lavonia Hotels
- Tiger Hotels
Explore more hotels
- Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
- 6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.
- Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock
- Fall fun at the cabin! Convenient to Lake Keowee and Clemson
- 😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks
- NEW! Beautiful 5 bedroom Lake Keowee Cove Home!
- Lake House with Dock, Pool, and Pet Friendly. 8 Minutes from Clemson, boat?
- Best Western Plus Clemson Hotel & Conference Center
- The Shepherd Hotel Downtown Clemson
- Inn @ Clemson
- Comfort Inn & Suites Clemson - University Area
- Days Inn by Wyndham Anderson
Expedia's Latest Trends
Flights
Flights to InverasdaleFlights to Shipton OliffeFlights to OdihamFlights to WhitminsterFlights to MaeshafnFlights to BelstoneFlights to CropstonFlights to Over KelletFlights to Port GaverneFlights to MaguiresbridgeFlights to PostlingFlights to KnaptonFlights to East WrethamFlights to Nant PerisFlights to EctonFlights to Hebden BridgeFlights to NetherleyFlights to NettlehamFlights to Newgate StreetFlights to DolbenmaenFlights to LoughbricklandFlights to Stow-on-the-WoldFlights to Kilmichael GlassaryFlights to KenmoreFlights to KirkcolmFlights to SittingbourneFlights to DarwenFlights to Sunderland