Photo by Cindy Keese

Find Resorts & Hotels with Spas in Seneca, SC

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Check availability on Seneca Resorts & Hotels with Spas

Compare Seneca Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Lakeside Lodge Clemson
Aerial view

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (808)
"Restaurant was awesome "
The price is SAR 409
SAR 504 total
includes taxes & fees
16 Mar - 17 Mar
Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
Terrace/patio

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (680)
"Great hotel for visiting Clemson. Clean and new and good service "
The price is SAR 427
SAR 470 total
includes taxes & fees
23 Mar - 24 Mar
Tru by Hilton Seneca Clemson
Quality Inn Seneca US-123
Room, 2 Double Beds, Accessible, Non Smoking | Pillowtop beds, desk, laptop workspace, blackout drapes

Quality Inn Seneca US-123

2.5 star property
8.0 out of 10, Very Good, (574)
"Clean and efficient somewhat dated"
The price is SAR 312
SAR 381 total
includes taxes & fees
31 Mar - 1 Apr
Quality Inn Seneca US-123
Days Inn by Wyndham Seneca / Clemson Area
Lobby

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (659)
"It was amazing everyone was so nice and the room was immaculate."
The price is SAR 258
SAR 284 total
includes taxes & fees
18 Mar - 19 Mar
Days Inn by Wyndham Seneca / Clemson Area
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
Outdoor spa tub

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

10.0 out of 10, Exceptional, (138)
"This house was perfect for a weekend getaway with 7 adults and 7 kids between the ages of 3-11. Beautiful view, spacious, stocked kitchen, quiet neighborhood, fun hot tub!"
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
Best Western Seneca-Clemson
Lobby

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very Good, (576)
"A quick one night stay here was good. Checkin staff was pleasant and efficient. Bed was comfy. Not premium lodging but very nice and not outdated. Room was clean. Breakfast was usual for this type of stay"
The price is SAR 335
SAR 368 total
includes taxes & fees
7 Apr - 8 Apr
Best Western Seneca-Clemson
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Fridge, microwave, oven, stovetop

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

10.0 out of 10, Exceptional, (83)
"If you are looking for an awesome place to gather with family and/or friends, look no further. We gathered to celebrate our grand daughter’s graduation from Clemson. It was the perfect spot. A great space with lots to do and plenty of room to spread out. The younger adults played ping pong and darts. The kitchen is fully equipped with everything you could possibly need with a gorgeous table to enjoy meals together. The views are breath taking from the living area. I personally loved several...
The price is SAR 2,832
SAR 5,891 total
includes taxes & fees
13 Mar - 14 Mar
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy!
Interior

Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy!

10.0 out of 10, Exceptional, (3)
"Beautiful property and a Great Lake experience for young children. Homeowners were very responsive and helpful."
Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy!
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
Exterior

Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub

10.0 out of 10, Exceptional, (44)
"Everything was great! Plenty of space for large gatherings or for smaller groups, or even to get some quiet alone time. Lots of games and activities available. "
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
The HART of Tiger Town! Lakefront home less than 4 miles to Clemson University
Miscellaneous

The HART of Tiger Town! Lakefront home less than 4 miles to Clemson University

7.0 out of 10, Good, (2)
"Thank you so much for letting us use your house. One of the guests who has ALS slipped out the shower and broke off the front corner of the lip to the toilet bowl. I have left money in the kitchen drawer to the right of the dishwasher to cover the expense"
The HART of Tiger Town! Lakefront home less than 4 miles to Clemson University
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
How many spa hotels will I find in Seneca?
Among Expedia’s 147 accommodation options in Seneca, there is 1 spa hotel.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Keowee Reservoir, Lake Keowee, and Keowee Key Golf Course. If you have extra time while you’re in the area, you might want to see Lake Hartwell and The Gauntlet.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.