Photo by Cindy Keese

Find Resorts & Hotels with Spas in Seneca, SC

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Check availability on Seneca Resorts & Hotels with Spas

Compare Seneca Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (779)
"Great place, will stay here again."
The price is SAR 409
SAR 504 total
includes taxes & fees
9 Feb - 10 Feb
Lakeside Lodge Clemson

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (670)
"2nd time staying here. Was just as wonderful as the my first stay. Staff was great!"
The price is SAR 435
SAR 479 total
includes taxes & fees
16 Feb - 17 Feb
Tru by Hilton Seneca Clemson

Quality Inn Seneca US-123

2.5 star property
8.0 out of 10, Very Good, (566)
"It wasn't amazing, but it was above average. Th hotel is located close to many amenities (stores, restaurants, etc.). Rooms were clean and reasonably new (no worn out furniture)."
The price is SAR 344
SAR 417 total
includes taxes & fees
28 Feb - 1 Mar
Quality Inn Seneca US-123

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (655)
"Good "
The price is SAR 274
SAR 302 total
includes taxes & fees
3 Mar - 4 Mar
Days Inn by Wyndham Seneca / Clemson Area

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

10.0 out of 10, Exceptional, (83)
"If you are looking for an awesome place to gather with family and/or friends, look no further. We gathered to celebrate our grand daughter’s graduation from Clemson. It was the perfect spot. A great space with lots to do and plenty of room to spread out. The younger adults played ping pong and darts. The kitchen is fully equipped with everything you could possibly need with a gorgeous table to enjoy meals together. The views are breath taking from the living area. I personally loved several...
The price is SAR 2,832
SAR 5,891 total
includes taxes & fees
9 Feb - 10 Feb
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy!

10.0 out of 10, Exceptional, (3)
"Beautiful property and a Great Lake experience for young children. Homeowners were very responsive and helpful."
Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy!

Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub

10.0 out of 10, Exceptional, (44)
"Everything was great! Plenty of space for large gatherings or for smaller groups, or even to get some quiet alone time. Lots of games and activities available. "
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub

Perfect Lake Hartwell Getaway - Gorgeous Lake Views!

10.0 out of 10, Exceptional, (80)
"We loved celebrating Christmas at this wonderful house. Three generations enjoyed the huge kitchen and multiple comfortable gathering spaces. Can’t wait to come back!"
Perfect Lake Hartwell Getaway - Gorgeous Lake Views!

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very Good, (571)
"Very sweet staff"
The price is SAR 335
SAR 368 total
includes taxes & fees
16 Feb - 17 Feb
Best Western Seneca-Clemson

What a family lake house should be! Natural Beauty w/ space for each to enjoy!!!

9.0 out of 10, Wonderful, (29)
"Overall, I highly recommend this place for anyone looking to unwind and enjoy some beautiful scenery. The house was exactly as described in the listing, which made our stay even more enjoyable. Waking up to those stunning views of the lake every morning was such a treat—it really set the perfect tone for our days. Communication with the owner was a breeze. They were super responsive and made sure we had everything we needed. Plus, the check-in and check-out process was incredibly easy, which...
What a family lake house should be! Natural Beauty w/ space for each to enjoy!!!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
How many spa hotels will I find in Seneca?
Among Expedia’s 147 accommodation options in Seneca, there is 1 spa hotel.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Keowee Reservoir, Lake Keowee, and Keowee Key Golf Course. If you have extra time while you’re in the area, you might want to see Lake Hartwell and Seneca Historic District.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.