Photo by Cindy Keese

Find Resorts & Hotels with Spas in Seneca, SC

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Check availability on Seneca Resorts & Hotels with Spas

Compare Seneca Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Lakeside Lodge Clemson
Aerial view

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (837)
"Great place"
The price is SAR 409
SAR 504 total
includes taxes & fees
21 Apr - 22 Apr
Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
Terrace/patio

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (697)
"Have stayed here multiple times as daughter attends Clemson University. Had a problem with the a/c unit and unfortunately had to change rooms but Hannah, the front desk host, was absolutely wonderful in dealing with the situation. So friendly, compassionate and professional. She deserves a raise :)"
The price is SAR 443
SAR 488 total
includes taxes & fees
27 Apr - 28 Apr
Tru by Hilton Seneca Clemson
Quality Inn Seneca US-123
Room, 2 Double Beds, Accessible, Non Smoking | Pillowtop beds, desk, laptop workspace, blackout drapes

Quality Inn Seneca US-123

2.5 star property
8.0 out of 10, Very Good, (581)
"First room smelled of stale cigarette smoke, otherwise i would've rated them higher. Staff was EXTREMELY friendly and helpful. Front desk clerk moved us immediately to a different room. That room was very nice and comfortable. Would stay there again."
The price is SAR 312
SAR 381 total
includes taxes & fees
5 May - 6 May
Quality Inn Seneca US-123
Days Inn by Wyndham Seneca / Clemson Area
Lobby

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (672)
"The people above us had the children running up and down well after 10pm--- coffee cups were very small"
The price is SAR 258
SAR 284 total
includes taxes & fees
20 Apr - 21 Apr
Days Inn by Wyndham Seneca / Clemson Area
Best Western Seneca-Clemson
Lobby

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very Good, (580)
"Very clean rooms, and nice staff."
The price is SAR 335
SAR 368 total
includes taxes & fees
22 Apr - 23 Apr
Best Western Seneca-Clemson
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
Outdoor spa tub

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

10.0 out of 10, Exceptional, (140)
"Super large property with room needed for everyone to have their own space. Equipped with everything needed and more. "
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
NEW! Beautiful 5 bedroom Lake Keowee Cove Home!
Fridge, microwave, oven, stovetop

NEW! Beautiful 5 bedroom Lake Keowee Cove Home!

9.4 out of 10, Exceptional, (8)
"We had the Best time at this home! The home was 2 storied with a door that separated the 2 living areas. Upstairs the adults could relax quietly by the inside fire, sit out on the porch and serve up the meals. Downstairs the college aged kids could hang out, play games or sit by the outdoor fire pit. There was so much to do at the home! Best part: Close to Clemson!! "
NEW! Beautiful 5 bedroom Lake Keowee Cove Home!
Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy!
Interior

Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy!

10.0 out of 10, Exceptional, (3)
"Beautiful property and a Great Lake experience for young children. Homeowners were very responsive and helpful."
Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy!
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
Exterior

Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub

10.0 out of 10, Exceptional, (44)
"Everything was great! Plenty of space for large gatherings or for smaller groups, or even to get some quiet alone time. Lots of games and activities available. "
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Fridge, microwave, oven, stovetop

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

10.0 out of 10, Exceptional, (83)
"If you are looking for an awesome place to gather with family and/or friends, look no further. We gathered to celebrate our grand daughter’s graduation from Clemson. It was the perfect spot. A great space with lots to do and plenty of room to spread out. The younger adults played ping pong and darts. The kitchen is fully equipped with everything you could possibly need with a gorgeous table to enjoy meals together. The views are breath taking from the living area. I personally loved several...
The price is SAR 2,833
SAR 5,895 total
includes taxes & fees
20 Apr - 21 Apr
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
How many spa hotels will I find in Seneca?
Among Expedia’s 147 accommodation options in Seneca, there is 1 spa hotel.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Keowee Reservoir, Lake Keowee, and Keowee Key Golf Course. If you have extra time while you’re in the area, you might want to see Lake Hartwell and Seneca Historic District.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.