Find hotels in Clayton, St. Louis from SAR 223
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Go beyond your typical stay in Clayton
Family friendly
Check prices for these dates
Tonight
Tomorrow
This weekend
Next weekend
Discover 1,837 Clayton hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay
9.0 out of 10, Wonderful, (3010)
The price is SAR 339
SAR 394 total
includes taxes & fees
13 Apr - 14 Apr

Le Méridien St. Louis Clayton
Le Méridien St. Louis Clayton
8.8 out of 10, Excellent, (580)
The price is SAR 596
SAR 701 total
includes taxes & fees
27 Mar - 28 Mar

The Ritz-Carlton, St. Louis
The Ritz-Carlton, St. Louis
9.2 out of 10, Wonderful, (526)
The price is SAR 2,172
SAR 2,530 total
includes taxes & fees
29 Mar - 30 Mar

AC Hotel St. Louis Clayton
AC Hotel St. Louis Clayton
8.8 out of 10, Excellent, (13)
The price is SAR 491
SAR 572 total
includes taxes & fees
30 Mar - 31 Mar

Residence Inn By Marriott St. Louis Clayton
Residence Inn By Marriott St. Louis Clayton
9.2 out of 10, Wonderful, (149)
The price is SAR 619
SAR 765 total
includes taxes & fees
20 Apr - 21 Apr

Hampton Inn & Suites Clayton/St. Louis-Galleria Area
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
9.0 out of 10, Wonderful, (827)
The price is SAR 443
SAR 521 total
includes taxes & fees
6 Apr - 7 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Where to stay in Clayton
Where to stay in Clayton
Hotels in top St. Louis neighborhoods Learn more about Clayton

Downtown St. Louis
2 out of top 10 points of interest in this area
4/5(4,004 area reviews)
Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Gateway Arch or Busch Stadium might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.
Recent reviews of Clayton hotels
Recent reviews of Clayton hotels

Drury Inn & Suites St. Louis Union Station
5/5 Excellent
"We really enjoyed our stay, the restaurant being downstairs was a huge plus!"
A verified traveler stayed at Drury Inn & Suites St. Louis Union Station
Posted 7 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top St. Louis neighborhoods
- Hotels in Downtown St. Louis
- Hotels in Clayton
- Hotels in Central West End
- Hotels in Soulard
- Hotels in Creve Coeur
- Hotels in St. Charles Historic District
- Hotels in Ladue
- Hotels in University City
- Hotels in Dogtown
- Hotels in The Grove
- Hotels in Lafayette Square
- Hotels in Botanical Heights
- Hotels in McKinley Heights
- Hotels in Fox Park
Hotels near popular St. Louis Attractions
- Hotels near Chapel of St. Timothy And St. Titus
- Hotels near Busch Stadium
- Hotels near St. Louis Union Station
- Hotels near Gateway Arch
- Hotels near St. Louis Zoo
- Hotels near Enterprise Center
- Hotels near Washington University in St. Louis
- Hotels near Forest Park
- Hotels near City Museum
- Hotels near Barnes Jewish Hospital
More Hotel Options in Clayton
- Adventure Hotels in Clayton
- Boutique Hotels in Clayton
- Business Hotels in Clayton
- Cheap Hotels in Clayton
- Family Hotels in Clayton
- Golf Hotels in Clayton
- Historic Hotels in Clayton
- Hotel Wedding Venues in Clayton
- Hotel with a Concierge in Clayton
- Hotels with Bars in Clayton
- Hotels with Free Parking in Clayton
- Hotels with Hot Tubs in Clayton
- Hotels with WiFi in Clayton
- Hotels with a Pool in Clayton
- Hotels with an Indoor Pool in Clayton
- Luxury Hotels in Clayton
- Pet-friendly Hotels in Clayton
- Resorts & Hotels with Spas in Clayton
- Romantic Hotels in Clayton
- Shopping Hotels in Clayton
Clayton Hotels by Star Rating
Explore more hotels
- Hollywood Casino & Hotel St. Louis
- Pear Tree Inn St. Louis Near Union Station
- Live by Loews - St.Louis
- Drury Inn & Suites St. Louis Union Station
- Embassy Suites by Hilton St. Louis Downtown
- Ameristar Casino Resort and Spa
- Casino Queen Hotel
- The Wildwood Hotel
- Best Western St. Louis-Kirkwood Route 66
- Renaissance St. Louis Airport Hotel
- Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
- DoubleTree by Hilton St. Louis Airport