Find Resorts & Hotels with Spas in Clayton, MO

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Check availability on Clayton Resorts & Hotels with Spas

Compare Clayton Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

3.0 star property
9.0 out of 10, Wonderful, (838)
"Is a good option and very good location. "
The price is SAR 507
SAR 596 total
includes taxes & fees
25 May - 26 May
Hampton Inn & Suites Clayton/St. Louis-Galleria Area

The Ritz-Carlton, St. Louis

5.0 star property
9.2 out of 10, Wonderful, (529)
"Great place"
The price is SAR 2,172
SAR 2,530 total
includes taxes & fees
27 Apr - 28 Apr
The Ritz-Carlton, St. Louis

Le Méridien St. Louis Clayton

4.0 star property
8.8 out of 10, Excellent, (593)
"Great stay! "
The price is SAR 596
SAR 701 total
includes taxes & fees
27 Apr - 28 Apr
Le Méridien St. Louis Clayton

Clayton Plaza Hotel & Extended Stay

3.5 star property
8.8 out of 10, Excellent, (2976)
"Great stay"
The price is SAR 374
SAR 436 total
includes taxes & fees
25 May - 26 May
Clayton Plaza Hotel & Extended Stay

Seven Gables, St. Louis West, a Tribute Portfolio Hotel

3.5 star property
8.4 out of 10, Very Good, (560)
"The hotel has is nice and quiet. "
The price is SAR 525
SAR 623 total
includes taxes & fees
27 Apr - 28 Apr
Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Residence Inn By Marriott St. Louis Clayton

3.0 star property
9.2 out of 10, Wonderful, (154)
"The hotel was extremely clean, which you don’t see that often today. The front desk staff was excellent. Will definitely stay here again."
The price is SAR 784
SAR 969 total
includes taxes & fees
25 Apr - 26 Apr
Residence Inn By Marriott St. Louis Clayton

King Bed, Comfy Environment, Cozy Space, Corporate Luxury

9.4 out of 10, Exceptional, (3)
"We thoroughly enjoyed our stay. The rooftop views are tremendous!"
King Bed, Comfy Environment, Cozy Space, Corporate Luxury
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Clayton?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travelers highly recommend the restaurants in Clayton. Be sure to pay a visit to the museums during your stay. Hotels with spas are the perfect way to break away from your daily routine and add a layer of luxury to your vacation.
How many spa hotels will I find in Clayton?
Among Expedia’s 10 accommodation options in Clayton, there are 3 spa hotels.
What's there to see and do in Clayton?
Enjoy all that Clayton has to offer when you visit Chapel of St. Timothy And St. Titus, Concordia Seminary, Enterprise Center, and St. Louis Zoo. If you have some spare time during your trip, you might want to check out St. Louis Union Station and Busch Stadium.
What is a Clayton spa hotel?
Spa hotels in Clayton provide lodging and have an on-site spa offering services including therapies as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.