Find Resorts & Hotels with Spas in Clayton, MO

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Compare Clayton Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Hampton Inn & Suites Clayton/St. Louis-Galleria Area
Exterior

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

3.0 star property
9.0 out of 10, Wonderful, (804)
"All was good "
The price is SAR 476
SAR 559 total
includes taxes & fees
12 Jan - 13 January 2025
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
The Ritz-Carlton, St. Louis
Exterior

The Ritz-Carlton, St. Louis

5.0 star property
9.2 out of 10, Wonderful, (522)
"We like everything. This was our first trip to St Louis. The hotel and surroundings exceeded all our expectations. We booked 3 rooms and they got us all on the same floor. It was Christmas and the decorations and festivities were wonderful."
The price is SAR 2,024
SAR 2,358 total
includes taxes & fees
26 Jan - 27 January 2025
The Ritz-Carlton, St. Louis
Le Méridien St. Louis Clayton
View from property

Le Méridien St. Louis Clayton

4.0 star property
8.8 out of 10, Excellent, (547)
"Rooms were updated"
The price is SAR 597
SAR 701 total
includes taxes & fees
2 Jan - 3 January 2025
Le Méridien St. Louis Clayton
Clayton Plaza Hotel & Extended Stay
Exterior

Clayton Plaza Hotel & Extended Stay

3.5 star property
9.0 out of 10, Wonderful, (2932)
"Excellent!!"
The price is SAR 375
SAR 436 total
includes taxes & fees
12 Jan - 13 January 2025
Clayton Plaza Hotel & Extended Stay
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Exterior

Seven Gables, St. Louis West, a Tribute Portfolio Hotel

3.5 star property
8.4 out of 10, Very Good, (552)
"The staff was terrific. "
The price is SAR 541
SAR 641 total
includes taxes & fees
11 Jan - 12 January 2025
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Residence Inn By Marriott St. Louis Clayton
Exterior

Residence Inn By Marriott St. Louis Clayton

3.0 star property
9.2 out of 10, Wonderful, (134)
"It was nice and clean Continental breakfast was hot and good And the service was great"
The price is SAR 605
SAR 747 total
includes taxes & fees
11 Jan - 12 January 2025
Residence Inn By Marriott St. Louis Clayton
King Bed, Comfy Environment, Cozy Space, Corporate Luxury
Living room of apartment offers comfort & a sleeper sofa.

King Bed, Comfy Environment, Cozy Space, Corporate Luxury

9.4 out of 10, Exceptional, (3)
"We thoroughly enjoyed our stay. The rooftop views are tremendous!"
King Bed, Comfy Environment, Cozy Space, Corporate Luxury
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Clayton?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travelers highly recommend the restaurants in Clayton. Be sure to pay a visit to the museums during your stay. Hotels with spas are the perfect way to break away from your daily routine and add a layer of luxury to your vacation.
How many spa hotels will I find in Clayton?
Among Expedia’s 10 accommodation options in Clayton, there are 3 spa hotels.
What's there to see and do in Clayton?
Enjoy all that Clayton has to offer when you visit Chapel of St. Timothy And St. Titus, Concordia Seminary, St. Louis Union Station, and Gateway Arch. If you have some spare time during your trip, you might want to check out Saint Louis Galleria Mall and The Loop.
What is a Clayton spa hotel?
Spa hotels in Clayton provide lodging and have an on-site spa offering services including therapies as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.