Find 5 Star Hotels in Clayton, MO from SAR 330
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Clayton 5 Star Hotels
Tonight
Tomorrow
This weekend
Next weekend
Compare Clayton 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Four Seasons Hotel St Louis
Four Seasons Hotel St Louis
9.4 out of 10, Exceptional, (993)
The price is SAR 1,482
SAR 1,733 total
includes taxes & fees
30 Mar - 31 Mar

The Ritz-Carlton, St. Louis
The Ritz-Carlton, St. Louis
9.2 out of 10, Wonderful, (526)
The price is SAR 2,172
SAR 2,530 total
includes taxes & fees
31 Mar - 1 Apr
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Clayton.

Hyatt Regency St. Louis at The Arch
315 Chestnut St, St. Louis, MO
The price is SAR 394 per night from Apr 18 to Apr 19
SAR 394
SAR 465 total
includes taxes & fees
18 Apr - 19 Apr
8.4/10 Very Good! (3,537 reviews)
Still don't see what you're looking for?
See all properties in Clayton.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Clayton
Love dining out, zoos, and museums? Get away to Clayton!

Explore a world of travel with Expedia
Explore a world of travel with Expedia
Clayton Hotels by Star Rating
Hotels in Clayton Neighborhoods
Stay near popular Clayton attractions
- Hotels near Chapel of St. Timothy And St. Titus
- Hotels near Busch Stadium
- Hotels near St. Louis Union Station
- Hotels near Gateway Arch
- Hotels near St. Louis Zoo
- Hotels near Enterprise Center
- Hotels near Washington University in St. Louis
- Hotels near Forest Park
- Hotels near City Museum
- Hotels near Barnes Jewish Hospital
- Hotels near America's Center Convention Complex
- Hotels near St. Louis University
- Hotels near Dome at America’s Center
- Hotels near Fox Theater
- Hotels near Ameristar Casino St. Charles
- Hotels near Hollywood Casino Amphitheatre
- Hotels near Mississippi River
- Hotels near Westport Plaza
- Hotels near Horseshoe St. Louis Casino
- Hotels near St Charles Convention Center
More Hotel Options in Clayton
- Adventure Hotels in Clayton
- Boutique Hotels in Clayton
- Business Hotels in Clayton
- Cheap Hotels in Clayton
- Family Hotels in Clayton
- Golf Hotels in Clayton
- Historic Hotels in Clayton
- Hotel Wedding Venues in Clayton
- Hotel with a Concierge in Clayton
- Hotels with Bars in Clayton
- Hotels with Free Parking in Clayton
- Hotels with Hot Tubs in Clayton
- Hotels with WiFi in Clayton
- Hotels with a Pool in Clayton
- Hotels with an Indoor Pool in Clayton
- Luxury Hotels in Clayton
- Pet-friendly Hotels in Clayton
- Resorts & Hotels with Spas in Clayton
- Romantic Hotels in Clayton
- Shopping Hotels in Clayton
Explore more hotels
- Hollywood Casino & Hotel St. Louis
- Pear Tree Inn St. Louis Near Union Station
- Drury Inn & Suites St. Louis Union Station
- Live by Loews - St.Louis
- Embassy Suites by Hilton St. Louis Downtown
- Ameristar Casino Resort and Spa
- Casino Queen Hotel
- The Wildwood Hotel
- Best Western St. Louis-Kirkwood Route 66
- Renaissance St. Louis Airport Hotel
- Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
- Hampton Inn St. Louis-Downtown (At the Gateway Arch)
- Hilton St. Louis at the Ballpark
- DoubleTree by Hilton St. Louis Airport
- Pear Tree Inn St. Louis Airport
- The Last Hotel
- Drury Inn & Suites St. Louis Airport
- The West End
- Wingate by Wyndham St. Louis/Fenton Route 66
- Holiday Inn St. Louis - Downtown Conv Ctr by IHG