Find 4 Star Hotels in St. Charles, MO from SAR 330
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on St. Charles 4 Star Hotels
Tonight
Tomorrow
Next weekend
In two weeks
Compare St. Charles 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch
8.4 out of 10, Very Good, (3617)
The price is SAR 394
SAR 465 total
includes taxes & fees
18 Apr - 19 Apr

Moonrise Hotel
Moonrise Hotel
9.0 out of 10, Wonderful, (1656)
The price is SAR 510
SAR 607 total
includes taxes & fees
20 Apr - 21 Apr

River City Casino & Hotel
River City Casino & Hotel
9.0 out of 10, Wonderful, (1150)
The price is SAR 330
SAR 439 total
includes taxes & fees
7 Apr - 8 Apr

DoubleTree by Hilton St. Louis Airport
DoubleTree by Hilton St. Louis Airport
7.8 out of 10, Good, (700)
The price is SAR 427
SAR 502 total
includes taxes & fees
13 Apr - 14 Apr

21C Museum Hotel St Louis
21C Museum Hotel St Louis
9.2 out of 10, Wonderful, (1054)
The price is SAR 605
SAR 726 total
includes taxes & fees
21 Apr - 22 Apr

Renaissance St. Louis Airport Hotel
Renaissance St. Louis Airport Hotel
8.4 out of 10, Very Good, (1009)
The price is SAR 443
SAR 518 total
includes taxes & fees
26 Apr - 27 Apr

Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
8.4 out of 10, Very Good, (1008)
The price is SAR 571
SAR 730 total
includes taxes & fees
20 Apr - 21 Apr

Live by Loews - St.Louis
Live by Loews - St.Louis
9.2 out of 10, Wonderful, (1012)
The price is SAR 634
SAR 754 total
includes taxes & fees
17 Apr - 18 Apr
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in St. Charles.

Four Seasons Hotel St Louis
999 North Second Street, St. Louis, MO
The price is SAR 1,579 per night from Apr 17 to Apr 18
SAR 1,579
SAR 1,846 total
includes taxes & fees
17 Apr - 18 Apr
9.4/10 Exceptional! (997 reviews)
Still don't see what you're looking for?
See all properties in St. Charles.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about St. Charles
Explore St. Charles: its history, live music, food, and more!

Recent reviews of St. Charles hotels
Recent reviews of St. Charles hotels

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
5/5 Excellent
"Excellent"
A verified traveler stayed at Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Posted 18 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
St. Charles Hotels by Star Rating
Hotels in St. Charles Neighborhoods
Stay near popular St. Charles attractions
- Hotels near Ameristar Casino St. Charles
- Hotels near St Charles Convention Center
- Hotels near Lindenwood University
- Hotels near Historic Main Street
- Hotels near Family Arena
- Hotels near Katy Trail
- Hotels near Fast Lane Classic Cars
- Hotels near Lewis & Clark Boathouse and Nature Center
- Hotels near Missouri Bluffs Golf Course
- Hotels near Weldon Spring Site Interpretive Center
- Hotels near First Missouri State Capitol Historic Site
- Hotels near Jaycee Park
- Hotels near Enterprise Center
- Hotels near St. Louis Union Station
- Hotels near Busch Stadium
- Hotels near Gateway Arch
- Hotels near St. Louis Zoo
- Hotels near Washington University in St. Louis
- Hotels near Forest Park
- Hotels near City Museum
More Hotel Options in St. Charles
- Adventure Hotels in St. Charles
- Business Hotels in St. Charles
- Casinos in St. Charles
- Cheap Hotels in St. Charles
- Family Hotels in St. Charles
- Golf Hotels in St. Charles
- Historic Hotels in St. Charles
- Hotel Wedding Venues in St. Charles
- Hotel with a Concierge in St. Charles
- Hotels with Bars in St. Charles
- Hotels with Free Parking in St. Charles
- Hotels with Hot Tubs in St. Charles
- Hotels with WiFi in St. Charles
- Hotels with a Pool in St. Charles
- Hotels with an Indoor Pool in St. Charles
- Hotels with smoking rooms in St. Charles
- Luxury Hotels in St. Charles
- Pet-friendly Hotels in St. Charles
- Resorts & Hotels with Spas in St. Charles
- Romantic Hotels in St. Charles
- Shopping Hotels in St. Charles
- Winery Hotels in St. Charles
Explore more hotels
- Moonrise Hotel
- Hollywood Casino & Hotel St. Louis
- River City Casino & Hotel
- Hampton Inn St. Louis-Downtown (At the Gateway Arch)
- Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
- Le Méridien St. Louis Clayton
- 21C Museum Hotel St Louis
- Live by Loews - St.Louis
- Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
- Hilton St. Louis at the Ballpark
- Embassy Suites by Hilton St. Louis Downtown
- Casino Queen Hotel
- The Wildwood Hotel
- Pear Tree Inn St. Louis Airport
- Best Western St. Louis-Kirkwood Route 66
- La Quinta Inn & Suites by Wyndham St. Louis Westport
- Drury Inn & Suites St. Louis Union Station
- The West End
- Pear Tree Inn St. Louis Near Union Station
- Wingate by Wyndham St. Louis/Fenton Route 66