Find hotels in Santa Ana, Panama City from SAR 228

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2 Oct - 3 Oct
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3 Oct - 4 Oct
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3 Oct - 5 Oct
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10 Oct - 12 Oct

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Discover 1,561 Santa Ana hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Casco View Apartments
Luxury Apartment | Balcony

Casco View Apartments

3.5 star property
9.4 out of 10, Exceptional, (48)
"Great stay, would recommend."
Casco View Apartments
Hotel República
Balcony

Hotel República

2.0 star property
6.6 out of 10, (176)
"Fantastic customer service"
Hotel República
ART CASCO The Hotel
Front of property

ART CASCO The Hotel

2.0 star property
6.6 out of 10, (8)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
ART CASCO The Hotel
Hostal La Cigarra
Bar (on property)

Hostal La Cigarra

2.5 star property
7.4 out of 10, Good, (53)
"Helpful staff, secure, close to sights"
Hostal La Cigarra
Hotel Riazor
Single Room | Free WiFi, bed sheets

Hotel Riazor

3.0 star property
3.8 out of 10, (11)
"Rough neighborhood "
Hotel Riazor
La Manzana by Wynwood House
Apartment (20) | 1 bedroom, iron/ironing board, free WiFi, bed sheets

La Manzana by Wynwood House

3.0 star property
7.0 out of 10, Good, (14)
"Great hotel. Very close to Casco viejo"
The price is SAR 162
SAR 253 total
includes taxes & fees
4 Oct - 5 Oct
La Manzana by Wynwood House
Casa Quijano 06 By Wynwood House
Apartment | Terrace/patio

Casa Quijano 06 By Wynwood House

4.0 star property
9.0 out of 10, Wonderful, (4)
"The apartment itself was very nice, very spacious, clean, newer furniture. Just know it’s on the third floor and there is no elevator. I didn’t see a sign on the building so it was a bit tricky to figure out which door to go to after being dropped off by the Uber. Email communication from property with building entry code and picture of the property was helpful. There are two balconies but all you really see is the apartment immediately in front of you, and so just know people can see you if you...
The price is SAR 213
SAR 358 total
includes taxes & fees
5 Oct - 6 Oct
Casa Quijano 06 By Wynwood House
Room-sofa Bed Stay Rooftop Pool & Gym, A
Room, Multiple Bedrooms, Accessible, Smoking | Pool | Outdoor pool

Room-sofa Bed Stay Rooftop Pool & Gym, A

2.0 star property
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
The price is SAR 527
SAR 583 total
includes taxes & fees
22 Oct - 23 Oct
Room-sofa Bed Stay Rooftop Pool & Gym, A
w Charming 1BR in Santa Ana s Best Area
Apartment | 1 bedroom, Internet

w Charming 1BR in Santa Ana s Best Area

2.0 star property
w Charming 1BR in Santa Ana s Best Area
Crowne Plaza Panama Airport by IHG
Outdoor pool, pool umbrellas, sun loungers

Crowne Plaza Panama Airport by IHG

4.0 star property
8.4 out of 10, Very Good, (2263)
"Great location "
The price is SAR 443
SAR 487 total
includes taxes & fees
1 Nov - 2 Nov
Crowne Plaza Panama Airport by IHG
Central Hotel Panama Casco Viejo
47-inch flat-screen TV with cable channels, TV

Central Hotel Panama Casco Viejo

4.0 star property
9.0 out of 10, Wonderful, (1000)
"Very beautiful hotel with helpful staff. Very good dining options. "
Central Hotel Panama Casco Viejo
La Concordia Boutique Hotel
Exclusive House | Terrace/patio

La Concordia Boutique Hotel

4.0 star property
9.4 out of 10, Exceptional, (184)
"Beautiful boutique hotel. Our room was large, bed is comfortable, nice selection of pillows, large balcony. Hotel staff is friendly and helpful. I highly recommend this place."
La Concordia Boutique Hotel
TRYP by Wyndham Panamá Centro
Exterior

TRYP by Wyndham Panamá Centro

3.5 star property
9.0 out of 10, Wonderful, (1004)
"Staff was very friendly and breakfast option were wide"
The price is SAR 306
SAR 337 total
includes taxes & fees
15 Oct - 16 Oct
TRYP by Wyndham Panamá Centro
The Westin Playa Bonita Panama
3 outdoor pools, pool umbrellas, sun loungers

The Westin Playa Bonita Panama

5.0 star property
8.0 out of 10, Very Good, (1000)
"Excelente hotel. "
The price is SAR 558
SAR 614 total
includes taxes & fees
16 Oct - 17 Oct
The Westin Playa Bonita Panama
Hotel Coral Suites
Reception

Hotel Coral Suites

3.5 star property
9.0 out of 10, Wonderful, (1000)
"Great location with spacious rooms "
The price is SAR 260
SAR 286 total
includes taxes & fees
4 Oct - 5 Oct
Hotel Coral Suites
Hotel Riu Plaza Panama
Outdoor pool, sun loungers

Hotel Riu Plaza Panama

5.0 star property
9.0 out of 10, Wonderful, (4332)
"Excellent stay!!"
The price is SAR 445
SAR 490 total
includes taxes & fees
5 Oct - 6 Oct
Hotel Riu Plaza Panama
Megapolis Hotel Panamá
Front of property

Megapolis Hotel Panamá

4.5 star property
8.4 out of 10, Very Good, (1107)
"Great place "
The price is SAR 469
SAR 516 total
includes taxes & fees
17 Oct - 18 Oct
Megapolis Hotel Panamá
Principe Hotel and Suites
Front of property - evening/night

Principe Hotel and Suites

3.0 star property
9.0 out of 10, Wonderful, (1481)
"Great place to stay"
The price is SAR 207
SAR 228 total
includes taxes & fees
15 Oct - 16 Oct
Principe Hotel and Suites
Riande Aeropuerto Hotel & Casino
Outdoor pool, open 7:00 AM to 10:30 PM, free cabanas, pool umbrellas

Riande Aeropuerto Hotel & Casino

4.0 star property
8.6 out of 10, Excellent, (1893)
"Nice hotel, close to the airport, friendly staff"
The price is SAR 559
SAR 615 total
includes taxes & fees
26 Oct - 27 Oct
Riande Aeropuerto Hotel & Casino
Novotel Panama City
Front of property

Novotel Panama City

4.0 star property
9.2 out of 10, Wonderful, (1001)
"The Staff were all welcoming location was very convenient I highly recommend "
The price is SAR 361
SAR 397 total
includes taxes & fees
19 Oct - 20 Oct
Novotel Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Punta Paitilla

Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Top Santa Ana Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"It was our first time at this hotel, everything was to our satisfaction."
Jean 5-night trip
Posted 15 hours ago
Hotel Riu Plaza Panama

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Santa Ana?

Santa Ana is a neighborhood that travelers like for its seafood restaurants, shopping, and parks. Are you looking for Santa Ana travel tips? Be sure to check out Cinta Costera and Avenida Balboa while you're in the neighborhood.

Where is the best hotel for a stay in Santa Ana?

Based on Expedia customer reviews, Hotel República is the highest ranked property in Santa Ana. This hotel is a short 4-minute walk from Avenida Balboa, and it offers a rooftop terrace and free WiFi. Another top choice in the area is Hostal La Cigarra.

How many hotels can I expect to find in Santa Ana?

Expedia has 116 hotels and other accommodations in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.

If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?

Yes! Most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Add dates, click "Search", then use the "fully refundable" filter to get top deals in Santa Ana.

Where can I learn more about changing or cancelling my trip to Santa Ana?

To find more details about picking new dates or cancelling your trip to Santa Ana, head over to our customer service page.

What is there to do in this Panama City neighborhood?

If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighborhood. Albrook Shopping Mall, Amador Theater, and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.