Find Luxury Hotels in Santee, SC

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Compare Santee Luxury Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Red Roof Inn Santee
Room

Red Roof Inn Santee

2.0 star property
6.6 out of 10, (583)
"Good!"
The price is SAR 252
SAR 279 total
includes taxes & fees
23 Dec - 24 Dec
Red Roof Inn Santee
Comfort Inn & Suites Santee
Lobby

Comfort Inn & Suites Santee

2.5 star property
8.0 out of 10, Very Good, (925)
" Very fast!"
The price is SAR 387
SAR 429 total
includes taxes & fees
7 Jan - 8 January 2025
Comfort Inn & Suites Santee
Baymont by Wyndham Santee
Exterior

Baymont by Wyndham Santee

2.5 star property
8.0 out of 10, Very Good, (1286)
"Desk staff was friendly and helpful. Room was clean and didnt smell like stale cigarettes. Water in the shower was hot!! So nice after a long drive."
The price is SAR 300
SAR 334 total
includes taxes & fees
23 Dec - 24 Dec
Baymont by Wyndham Santee
Ramada by Wyndham Santee I-95
Room

Ramada by Wyndham Santee I-95

2.0 star property
6.2 out of 10, (505)
"The people were weird outside and the ice bucket didn’t come with a plastic bag in it. Everything else was good. Clean room, friendly man at the desk. "
The price is SAR 300
SAR 333 total
includes taxes & fees
6 Jan - 7 January 2025
Ramada by Wyndham Santee I-95
Econo Lodge
Exterior

Econo Lodge

2.0 star property
6.4 out of 10, (304)
"Check in was easy."
The price is SAR 241
SAR 267 total
includes taxes & fees
5 Jan - 6 January 2025
Econo Lodge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Are you looking for a luxury hotel for your stay in Santee?
Let Expedia help you arrange your flight to Columbia Metropolitan Airport (CAE) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you’d like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that Santee has to offer. During your visit, you might want to enjoy the restaurants and coffee shops which Santee is known for.
How many luxury hotels will I be able to find in Santee?
Lie in the lap of luxury during your getaway to Santee in one of Expedia’s 8 luxury hotels.
When can I expect good weather in Santee?
Planning for the weather is an important factor for making your trip to Santee a success, especially when you’re splurging. The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Santee is 55 inches.
What's there to see and do in Santee?
Enjoy all that Santee has to offer and visit Santee Cooper Country Club, Santee Outlets, and Santee National Golf Club. If you have a little extra time during your trip, you might want to make a stop at Santee State Park and Lake Marion.