Find Resorts & Hotels with Spas in Florence, SC

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Pick from 10 Florence Resorts & Hotels with Spas and compare room rates, reviews, and availability. Most hotels are fully refundable.

Hampton Inn & Suites Florence Center
Exterior
Hampton Inn & Suites Florence Center
2.5 star property
9.2 out of 10, Wonderful, (666)
"very friendly staff. Conveniently located close to I-95 with shopping close by"
The price is SAR 460
SAR 515 total
includes taxes & fees
1 Dec - 2 Dec
Hampton Inn & Suites Florence Center
Comfort Inn & Suites
Exterior
Comfort Inn & Suites
2.5 star property
9.2 out of 10, Wonderful, (1007)
"From the friendly greeting to comfy bed we were happy with our stay. A quick stop over in our travels. There are restaurants close by and shopping if you like that."
The price is SAR 358
SAR 400 total
includes taxes & fees
24 Nov - 25 Nov
Comfort Inn & Suites
Homewood Suites by Hilton Florence
Exterior
Homewood Suites by Hilton Florence
3.0 star property
8.4 out of 10, Very Good, (570)
"Very nice room. Spacious and quiet Conveniet Tesla charger "
The price is SAR 492
SAR 551 total
includes taxes & fees
24 Nov - 25 Nov
Homewood Suites by Hilton Florence
Comfort Suites Florence I-95
Room
Comfort Suites Florence I-95
2.5 star property
8.6 out of 10, Excellent, (1000)
"We love this area and stay at the same hot heading north or south It’s easy access on and off 95"
The price is SAR 343
SAR 399 total
includes taxes & fees
24 Nov - 25 Nov
Comfort Suites Florence I-95
Country Inn & Suites by Radisson, Florence, SC
Exterior
Country Inn & Suites by Radisson, Florence, SC
2.5 star property
7.4 out of 10, Good, (1004)
"It was very clean and safe. I checked in at 1 am and was still greeted, didn't feel concerned about my well being."
The price is SAR 309
SAR 356 total
includes taxes & fees
24 Nov - 25 Nov
Country Inn & Suites by Radisson, Florence, SC
TownePlace Suites by Marriott Florence
Pool
TownePlace Suites by Marriott Florence
2.5 star property
9.0 out of 10, Wonderful, (552)
"Very nice and relaxing "
The price is SAR 448
SAR 501 total
includes taxes & fees
24 Nov - 25 Nov
TownePlace Suites by Marriott Florence
Howard Johnson by Wyndham Florence
Exterior
Howard Johnson by Wyndham Florence
2.0 star property
8.8 out of 10, Excellent, (2015)
"Buildings and grounds older but in good condition. Parking convenient and very well lit lot felt very safe. Rooms and furnishings good condition. Bathrooms new fixtures. Large refrigerator with separate freezer. Comfortable bedding and new carpet. Left early and didn’t have the breakfast "
The price is SAR 233
SAR 261 total
includes taxes & fees
12 Nov - 13 Nov
Howard Johnson by Wyndham Florence
Park Inn by Radisson Florence, SC
Exterior
Park Inn by Radisson Florence, SC
2.5 star property
9.0 out of 10, Wonderful, (1783)
"Dog friendly stop in the way to FL"
The price is SAR 301
SAR 337 total
includes taxes & fees
10 Nov - 11 Nov
Park Inn by Radisson Florence, SC
Staybridge Suites Florence - Civic Center, an IHG Hotel
Exterior
Staybridge Suites Florence - Civic Center, an IHG Hotel
3.0 star property
9.4 out of 10, Exceptional, (747)
"⁶"
The price is SAR 477
SAR 534 total
includes taxes & fees
5 Dec - 6 Dec
Staybridge Suites Florence - Civic Center, an IHG Hotel
Tru by Hilton Florence I-95
Exterior
Tru by Hilton Florence I-95
2.5 star property
8.2 out of 10, Very Good, (1008)
"Location perfect for overnight layover."
The price is SAR 380
SAR 426 total
includes taxes & fees
17 Nov - 18 Nov
Tru by Hilton Florence I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking to vacation at a spa hotel in Florence?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travelers highly recommend the restaurants in Florence. Be sure to pay a visit to the museums during your stay. Spa hotels are a great way to break out of your routine and add a layer of luxury to your holiday.
What is the best spa hotel in Florence?
Hotel Florence, Tapestry Collection by Hilton is a top spa hotel featuring a 24-hour fitness center, a bar, and a restaurant. Enjoy a facial, detox wrap, or Swedish massage at the onsite spa.
How many spa hotels are there in Florence?
Among Expedia’s 89 accommodation options in Florence, there is 1 spa hotel.
What's there to see and do in Florence?
Enjoy all that Florence has to offer when you visit Florence Museum, Florence National Cemetery, and Magnolia Mall. If you have extra time while you’re in the area, you might want to see Florence Civic Center and Palmetto Shores Lake.
What is a Florence spa hotel?
Spa hotels in Florence provide lodging and have an on-site spa which offers services like couples massages as well as body treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.