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Compare 149 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
9.4 out of 10, Exceptional, (139)
The price is SAR 596
SAR 687 total
includes taxes & fees
19 Mar - 20 Mar

The Conner House B&B
The Conner House B&B
10.0 out of 10, Exceptional, (13)
The price is SAR 527
SAR 585 total
includes taxes & fees
16 Apr - 17 Apr

Corner George Inn Bed & Breakfast
Corner George Inn Bed & Breakfast
9.0 out of 10, Wonderful, (151)
The price is SAR 482
SAR 535 total
includes taxes & fees
18 Mar - 19 Mar

Postcard Cabins St. Francois
Postcard Cabins St. Francois
10.0 out of 10, Exceptional, (3)
The price is SAR 338
SAR 363 total
includes taxes & fees
30 Mar - 31 Mar

Tiny Houses of French Village
Tiny Houses of French Village
10.0 out of 10, Exceptional, (2)
The price is SAR 926
SAR 1,372 total
includes taxes & fees
17 Mar - 18 Mar

Drury Inn & Suites St. Louis Arnold
Drury Inn & Suites St. Louis Arnold
9.6 out of 10, Exceptional, (1001)
The price is SAR 506
SAR 585 total
includes taxes & fees
23 Mar - 24 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Photo by Jessica King
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More cheap stays in De Soto
More cheap stays in De Soto

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
The price is SAR 195 per night from Apr 6 to Apr 7
SAR 195
SAR 222 total
includes taxes & fees
6 Apr - 7 Apr
8/10 Very Good! (873 reviews)
Stay near popular De Soto attractions
Stay near popular De Soto attractions
Recent reviews of De Soto hotels
Recent reviews of De Soto hotels

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
5/5 Excellent
"Stayed for work. Was exactly what I needed for good price. Will stay again if in the area."
A verified traveler from Novinger stayed at La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Posted 2 days ago
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Stay near popular De Soto attractions
- Hotels near Mississippi River
- Hotels near Bonne Terre Mine
- Hotels near Meramec State Park
- Hotels near Meramec River
- Hotels near Pickle Springs Natural Area
- Hotels near St. Francois State Park
- Hotels near Hawn State Park
- Hotels near St. Joe State Park
- Hotels near Villa Antonio Winery
- Hotels near Washington State Park
- Hotels near Crown Pointe Golf Club
- Hotels near Missouri Mines State Historic Site
Hotels near De Soto Airports
Other Hotels near De Soto, Missouri
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- Central United States Hotels
- Pacific Hotels
- St. Clair Hotels
- Potosi Hotels
- Union Hotels
- Bonne Terre Hotels
- Bourbon Hotels
- Waterloo Hotels
- Tesson Ferry Hotels
- Imperial Hotels
- Park Hills Hotels
Explore more hotels
- Quality Inn Farmington
- WoodSpring Suites St. Louis Arnold
- Super 8 by Wyndham Farmington
- Super 8 by Wyndham Bonne Terre
- Super 8 by Wyndham Potosi
- Quality Inn Festus
- Hampton Inn Farmington
- Crown Pointe Lodge, BW Signature Collection
- Cabin 1 at the Pallet Factory
- Holiday Inn Express & Suites Farmington by IHG
- Treehouse and Hot Tub on 10acres - Pet Friendly!
- Charming 1-bedroom house in nice Imperial with AC. Attn! Traveling Contractors