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Compare 162 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
9.4 out of 10, Exceptional, (141)
The price is SAR 596
SAR 687 total
includes taxes & fees
13 May - 14 May

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
9.4 out of 10, Exceptional, (634)
The price is SAR 521
SAR 596 total
includes taxes & fees
18 May - 19 May

Comfort Inn Festus - St Louis South
Comfort Inn Festus - St Louis South
8.0 out of 10, Very Good, (810)
The price is SAR 335
SAR 392 total
includes taxes & fees
8 Jun - 9 Jun

Festus Inn
Festus Inn
2.0 out of 10, (1)
The price is SAR 375
SAR 429 total
includes taxes & fees
9 May - 10 May

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
8.0 out of 10, Very Good, (784)
The price is SAR 478
SAR 547 total
includes taxes & fees
8 Jun - 9 Jun

Tiny Houses of French Village
Tiny Houses of French Village
10.0 out of 10, Exceptional, (2)
The price is SAR 799
SAR 1,237 total
includes taxes & fees
9 May - 10 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Photo by Jessica King
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More cheap stays in De Soto
More cheap stays in De Soto

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
The price is SAR 209 per night from May 11 to May 12
SAR 209
SAR 238 total
includes taxes & fees
11 May - 12 May
8/10 Very Good! (935 reviews)
Hotels in De Soto with star-rating
Hotels in De Soto with star-rating

3 Star Hotels
9 properties

2 Star Hotels
30 properties
Stay near popular De Soto attractions
Stay near popular De Soto attractions
Recent reviews of De Soto hotels
Recent reviews of De Soto hotels

Postcard Cabins St. Francois
5/5 Excellent
"Awesome.. "
A verified traveler stayed at Postcard Cabins St. Francois
Posted 1 day ago
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Stay near popular De Soto attractions
- Hotels near Mississippi River
- Hotels near Meramec State Park
- Hotels near Meramec River
- Hotels near Bonne Terre Mine
- Hotels near Pickle Springs Natural Area
- Hotels near Hawn State Park
- Hotels near Big River
- Hotels near St. Francois State Park
- Hotels near St. Joe State Park
- Hotels near Washington State Park
- Hotels near Crown Pointe Golf Club
- Hotels near Villa Antonio Winery
Hotels near De Soto Airports
De Soto Hotels by Brand
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Explore more hotels
- Super 8 by Wyndham Bonne Terre
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
- Quality Inn Farmington
- Crown Pointe Lodge, BW Signature Collection
- Postcard Cabins St. Francois
- Super 8 by Wyndham Potosi
- Hampton Inn Farmington
- WoodSpring Suites St. Louis Arnold
- Holiday Inn Express & Suites Farmington by IHG
- Lake Haven - Updated Mid Century Cabin Only 35 Mins from St. Louis
- Cute Ranch -safe and quiet- 1800 sft living space
- Treehouse and Hot Tub on 10acres - Pet Friendly!