Find all hotels by Motel 6 in Upstate South Carolina, SC
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check prices for these dates
Tonight
Tomorrow
This weekend
Next weekend
Compare rooms and suites by Motel 6 in Upstate South Carolina with rates, reviews, and availability. Most hotels are fully refundable.

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
8.6 out of 10, Excellent, (1001)
The price is SAR 372
SAR 409 total
includes taxes & fees
20 Apr - 21 Apr

Grand Bohemian Lodge Greenville, Autograph Collection
Grand Bohemian Lodge Greenville, Autograph Collection
9.6 out of 10, Exceptional, (329)
The price is SAR 1,010
SAR 1,111 total
includes taxes & fees
20 Apr - 21 Apr

Hilton Greenville
Hilton Greenville
8.0 out of 10, Very Good, (1000)
The price is SAR 388
SAR 439 total
includes taxes & fees
19 Apr - 20 Apr

Hyatt Place Greenville/Downtown
Hyatt Place Greenville/Downtown
9.2 out of 10, Wonderful, (1002)
The price is SAR 481
SAR 545 total
includes taxes & fees
20 Apr - 21 Apr

Embassy Suites Greenville Golf Resort & Conference Center
Embassy Suites Greenville Golf Resort & Conference Center
8.8 out of 10, Excellent, (1001)
The price is SAR 471
SAR 534 total
includes taxes & fees
17 Apr - 18 Apr

Hyatt Regency Greenville
Hyatt Regency Greenville
8.6 out of 10, Excellent, (1001)
The price is SAR 507
SAR 574 total
includes taxes & fees
20 Apr - 21 Apr

Cambria Hotel Greenville
Cambria Hotel Greenville
9.4 out of 10, Exceptional, (996)
The price is SAR 428
SAR 470 total
includes taxes & fees
20 Apr - 21 Apr

Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & Suites
9.2 out of 10, Wonderful, (1335)
The price is SAR 318
SAR 349 total
includes taxes & fees
20 Apr - 21 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Recent reviews of Upstate South Carolina hotels
Recent reviews of Upstate South Carolina hotels

Hyatt Regency Greenville
5/5 Excellent
"Great location"
A verified traveler stayed at Hyatt Regency Greenville
Posted 3 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Upstate South Carolina Hotels by Brand
Hotels near popular Upstate South Carolina Attractions
- Hotels near Clemson University
- Hotels near Falls Park on the Reedy
- Hotels near BMW Performance Center
- Hotels near Haywood Mall
- Hotels near Bon Secours Wellness Arena
- Hotels near Lake Jocassee
- Hotels near Prisma Health Greenville Memorial Hospital
- Hotels near Greenville Convention Center
- Hotels near The Peace Center
- Hotels near Bob Jones University
More Hotel Options in Upstate South Carolina
- Adults Only Resorts & Hotels in Upstate South Carolina
- Adventure Hotels in Upstate South Carolina
- Beach Hotels in Upstate South Carolina
- Boutique Hotels in Upstate South Carolina
- Business Hotels in Upstate South Carolina
- Cheap Hotels in Upstate South Carolina
- Family Hotels in Upstate South Carolina
- Golf Hotels in Upstate South Carolina
- Historic Hotels in Upstate South Carolina
- Hotel Wedding Venues in Upstate South Carolina
- Hotel with a Concierge in Upstate South Carolina
- Hotels with Bars in Upstate South Carolina
- Hotels with Early Check-in in Upstate South Carolina
- Hotels with Free Parking in Upstate South Carolina
- Hotels with Hot Tubs in Upstate South Carolina
- Hotels with WiFi in Upstate South Carolina
- Hotels with a Pool in Upstate South Carolina
- Hotels with an Indoor Pool in Upstate South Carolina
- Hotels with smoking rooms in Upstate South Carolina
- Luxury Hotels in Upstate South Carolina
- Pet-friendly Hotels in Upstate South Carolina
- Resorts & Hotels with Spas in Upstate South Carolina
- Romantic Hotels in Upstate South Carolina
- Shopping Hotels in Upstate South Carolina
- Ski Hotels in Upstate South Carolina
More Accommodation Types in Upstate South Carolina
Explore more hotels
- Courtyard by Marriott Greenville Haywood Mall
- Best Western Plus Clemson Hotel & Conference Center
- Homewood Suites by Hilton Greenville Downtown
- Lakeside Lodge Clemson
- The Shepherd Hotel Downtown Clemson
- Mint House Greenville - Downtown
- Holiday Inn Greenville - Woodruff Road by IHG
- Hyatt Place Greenville/Haywood
- Wingate by Wyndham - Greenville-Airport
- Drury Inn & Suites Greenville
- Inn @ Clemson
- Comfort Suites At WestGate Mall
- Spartanburg Marriott
- ECHO Suites Extended Stay by Wyndham Spartanburg
- Postcard Cabins Lake Hartwell
- Best Western Plus Spartanburg
- Holiday Inn Express Hotel & Suites Spartanburg-North by IHG
- Fairfield Inn & Suites by Marriott Greenville Simpsonville
- Courtyard Greenville-Spartanburg by Marriott
- Tru by Hilton Seneca Clemson