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Compare 241 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Sun Hotel

3.5 star property
8.2 out of 10, Very Good, (281)
"Necesitan personas que hablen ingles en el hotel. Por lo monos en la recepsion"
The price is SAR 405
SAR 405 total
includes taxes & fees
23 Feb - 24 Feb
Sun Hotel

Marriott Santa Cruz de la Sierra Hotel

5.0 star property
9.0 out of 10, Wonderful, (181)
"Quiet place. Very safe and clean."
The price is SAR 363
SAR 363 total
includes taxes & fees
7 Mar - 8 Mar
Marriott Santa Cruz de la Sierra Hotel

Swissôtel Santa Cruz De La Sierra

4.5 star property
9.2 out of 10, Wonderful, (75)
"Beautiful hotel"
The price is SAR 552
SAR 552 total
includes taxes & fees
8 Mar - 9 Mar
Swissôtel Santa Cruz De La Sierra

TRYP by Wyndham Santa Cruz

4.0 star property
9.4 out of 10, Exceptional, (106)
"Will return."
The price is SAR 259
SAR 259 total
includes taxes & fees
23 Feb - 24 Feb
TRYP by Wyndham Santa Cruz

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 star property
9.2 out of 10, Wonderful, (222)
"Very nice accommodations, clean, very friendly and helpful staff"
The price is SAR 282
SAR 282 total
includes taxes & fees
23 Feb - 24 Feb
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hotel LP Equipetrol

3.5 star property
8.2 out of 10, Very Good, (198)
"O quarto é amplo, super limpo, chuveiro ótimo, roupa de cama e toalhas bem limpas, funcionários são simpáticos. Não gostei do café da manhã e a internet é péssima. Localização também é ótima. "
The price is SAR 267
SAR 286 total
includes taxes & fees
25 Feb - 26 Feb
Hotel LP Equipetrol

Camino Real Hotel

4.5 star property
8.8 out of 10, Excellent, (372)
"Beautiful property!! Staff, location and food outstanding. I go back every time I’m in Bolivia."
The price is SAR 489
SAR 489 total
includes taxes & fees
24 Feb - 25 Feb
Camino Real Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 star property
9.0 out of 10, Wonderful, (311)
"Very good quality hotel in beautiful Santa Cruz, Bolivia. Friendly staff Clean grounds "
The price is SAR 476
SAR 476 total
includes taxes & fees
16 Mar - 17 Mar
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Premium Suites Deluxe Aparthotel Equipetrol

3.5 star property
9.0 out of 10, Wonderful, (67)
"Very clean! "
The price is SAR 200
SAR 200 total
includes taxes & fees
23 Feb - 24 Feb
Premium Suites Deluxe Aparthotel Equipetrol

Hotel Continental Park

3.0 star property
8.8 out of 10, Excellent, (23)
"This is a great option for accomodations near the center of the city. Perhaps 5 or 6 block walk to the main square. Lots of options for restaurantes. The garage is easily accesible. The pool was great and we took advantage of the sauna. Breakfast was great as well. Good variety of food. Staff at the desk was polite and helpful. "
The price is SAR 287
SAR 287 total
includes taxes & fees
1 Mar - 2 Mar
Hotel Continental Park

Hotel Cortez

3.5 star property
9.0 out of 10, Wonderful, (97)
"The Cortez Hotel was an amazing experience. Thanks!"
The price is SAR 432
SAR 432 total
includes taxes & fees
1 Mar - 2 Mar
Hotel Cortez

Hotel G

3.5 star property
7.8 out of 10, Good, (102)
"excelente ubicación, muy cómodo el lugar."
The price is SAR 158
SAR 158 total
includes taxes & fees
23 Feb - 24 Feb
Hotel G

Alfonsina Hotel Boutique by Inboccaluppo

3.5 star property
9.6 out of 10, Exceptional, (32)
"Love it. Will stay again!!"
The price is SAR 387
SAR 387 total
includes taxes & fees
7 Mar - 8 Mar
Alfonsina Hotel Boutique by Inboccaluppo

Apart Hotel Premium Suites Santa Cruz

3.5 star property
8.6 out of 10, Excellent, (85)
"Good location, spacious apartment, good stay overall"
The price is SAR 113
SAR 113 total
includes taxes & fees
23 Feb - 24 Feb
Apart Hotel Premium Suites Santa Cruz

Terranova Suites

3.5 star property
8.0 out of 10, Very Good, (89)
"The pictures of the property have to be from a decade ago. This place it is dirty and in poor shape. "
The price is SAR 183
SAR 183 total
includes taxes & fees
10 Mar - 11 Mar
Terranova Suites

Novotel Santa Cruz De La Sierra

5.0 star property
9.2 out of 10, Wonderful, (84)
"Great hotel and location also very nice staff."
The price is SAR 394
SAR 394 total
includes taxes & fees
8 Mar - 9 Mar
Novotel Santa Cruz De La Sierra

Hotel LP Santa Cruz Centro

3.0 star property
7.8 out of 10, Good, (277)
"Clean, friendly staff"
The price is SAR 153
SAR 172 total
includes taxes & fees
26 Feb - 27 Feb
Hotel LP Santa Cruz Centro

Chairú Eco Hotel

3.5 star property
9.6 out of 10, Exceptional, (31)
"The staff was extremely helpful. Due to our flight schedule we arrived 6 hours prior to check-in. Once a room became available that morning after a guest checked out, they got it cleaned immediately and got us in several hours before our actual check in. We were extremely grateful for their kindness. "
The price is SAR 169
SAR 169 total
includes taxes & fees
3 Mar - 4 Mar
Chairú Eco Hotel

HOTEL OSHO

3.5 star property
9.0 out of 10, Wonderful, (23)
"I like his service "
The price is SAR 305
SAR 305 total
includes taxes & fees
1 Mar - 2 Mar
HOTEL OSHO

Hotel Maywa

4.0 star property
9.0 out of 10, Wonderful, (4)
"Personal atento, buen desayuno continental y habitaciones amplias y modernas "
The price is SAR 150
SAR 150 total
includes taxes & fees
23 Feb - 24 Feb
Hotel Maywa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Great weekend hotel deals in Santa Cruz

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Learn more about Santa Cruz

Experience Bolivia as the locals see it in the country’s busiest city, where the museums, public squares and churches give you a glimpse into their everyday lives.

San Lorenzo Cathedral showing a garden

Frequently asked questions

What's the best place for a stay in Santa Cruz?

Ibis Santa Cruz DE LA Sierra is a favorite with Expedia customers. This hotel offers a restaurant and free parking. Reviews from our site also recommend Alfonsina Hotel Boutique by Inboccaluppo and Chairú Eco Hotel as top options for your trip. See all available top hotels, or vacation rentals in Santa Cruz.

What's the top vacation rental that Santa Cruz has to offer?

Casa Vida: Visitors give good reviews to this Santa Cruz vacation home rental, which is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. Some other homes for rent in Santa Cruz include Mi casa su casa, moderna y chic. and Jose Luis Noya. See all vacation rentals in Santa Cruz.

If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?

Yes! Most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.

Where can I learn more about changing or cancelling my trip to Santa Cruz?

To find more details about picking new dates or cancelling your trip to Santa Cruz, head over to our customer service page.

What's the best budget-friendly accommodation in Santa Cruz?

Based on our traveler reviews, Hostal Killa is a top choice for a less expensive stay. Other choices for your budget-friendly stay include residencial francia - Hostel and Hostal Ibiza. View all budget hotels in Santa Cruz.

What's the best accommodation for a family trip to Santa Cruz?

Marriott Santa Cruz de la Sierra Hotel is a hotel with an outdoor pool and a restaurant, and it's a top choice on Expedia for families. Other choices for your stay with the kids include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Novotel Santa Cruz De La Sierra. Attractions like Santa Cruz Zoo and Play Land Amusement Park are also fun for kids of all ages. Find more child-friendly accommodations in Santa Cruz.

What is the top LGBTQ-friendly accommodation in Santa Cruz?

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free WiFi. Swissôtel Santa Cruz De La Sierra and Radisson Hotel Santa Cruz are other good choices for your trip.

What's the best pet-friendly hotel in Santa Cruz?

Ibis Santa Cruz DE LA Sierra is a top hotel for people traveling with their pets, and offers a restaurant and free WiFi for its human guests. Other good options for you and your pet's trip include Swissôtel Santa Cruz De La Sierra and Hotel G. See more pet-friendly hotel accommodations in Santa Cruz.

Where is the best place to stay close to Plaza 24 de Septiembre?

Adjacent to Plaza 24 de Septiembre, Nomad Hostel is one of the top choices for your stay based on our traveler data, and this property offers a restaurant and a bar. Other good options close by include Senses Centro and Cosmopolitano Hotel Boutique.

What about the best place to stay near Ventura Mall?

One of the top choices for your stay is Camino Real Hotel, located next to Ventura Mall, and this 4-star hotel offers 2 bars and a restaurant. Los Tajibos Hotel And Convention Center and Marriott Santa Cruz de la Sierra Hotel are two other good choices in the immediate area.

What's the best luxury accommodation in Santa Cruz?

Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Novotel Santa Cruz De La Sierra and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia are other upscale choices for your vacation. Find more luxury hotels in Santa Cruz.

What are some accommodations with pools in Santa Cruz?

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a top hotel with 2 outdoor pools, a children's pool, and 2 restaurants. A couple of other options that offer an onsite pool include Sun Hotel and Yotau All Suites Hotel. View all hotels with pools in Santa Cruz.

What is the best spa hotel in Santa Cruz?

Marriott Santa Cruz de la Sierra Hotel is a top luxury spa hotel featuring a rooftop terrace, a fitness center, tennis courts, and a bar. Spend an afternoon at Hotel Spa where you’ll find massage treatments. Other popular spa hotels in Santa Cruz include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Camino Real Hotel. See all spa hotels in Santa Cruz.

What's the best hotel for staying near Viru Viru International Airport (VVI)?

Sun Hotel is a popular 3.5-star hotel featuring free breakfast and a restaurant. It's located a short 1.3 mi (2.1 km) from Viru Viru Intl. Airport.

How is it to stay in Santa Cruz?

Visitors to Santa Cruz are sure to enjoy the shopping. Tourists can also enjoy the city's cafes, zoo, and cathedral. In Santa Cruz, there are 233 hotels and other accommodations to choose from. Find out more about Santa Cruz.

What should I do while I'm visiting Santa Cruz?

Cultural venues include Cine Center, Ethno-folkloric Museum, and Sacred Art Museum. Landmarks like San Lorenzo Cathedral, Plaza 24 de Septiembre, and Blacutt Square might be worth a visit. Natural beauty is on display at Guembe Biocenter, Arenal Park, and Lomas de Arena Regional Park. Check out what more to see and do in Expedia's Santa Cruz guide.

How should I get around Santa Cruz?

To see more of the larger area, ride aboard one of the trains from Santa Cruz de la Sierra Station. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.

What's the weather like in Santa Cruz?

The hottest months are usually October and November with an average temp of 79°F, while the coldest months are June and July with an average of 70°F. Average annual precipitation for Santa Cruz is 48 inches.