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Compare 479 Vacation Homes in Picayune with updated reviews, rates, and availability.

On the Beach, Teddy Roosevelt Stayed Here. Pet friendly, large fenced property

9.6 out of 10, Exceptional, (229)
"Always a relaxing place to stay rain or shine."
On the Beach, Teddy Roosevelt Stayed Here. Pet friendly, large fenced property

On Main St! Private Heated pool, Golf cart included, Sleeps 10

10.0 out of 10, Exceptional, (34)
"There were 8 of us women celebrating a 60th birthday. The house was perfect for us with plenty of room. The location is in the middle of everything or within walking distance to restaurants, shops and bars. Brandon's response time was impeccable. The kitchen well accommodated our cooking needs! We had the best time! The weather sadly didn't cooperate with us to partake in the outdoor amenities, but we will be back! "
On Main St! Private Heated pool, Golf cart included, Sleeps 10

Cheerful 4 Bedroom Home in Downtown Depot District

10.0 out of 10, Exceptional, (35)
"We loved our stay here. It comfortably slept 8 adults and the common areas were set up so we could all easily socialize. The house was spotless and everything we needed for an enjoyable weekend was provided. The location is good, everything is a short golf cart ride away. Highly recommend. "
Cheerful 4 Bedroom Home in Downtown Depot District

St George Cottage

10.0 out of 10, Exceptional, (23)
"This is a lovely, eclectic cottage. The owner was wonderful regarding the check-in process and had even some nice treats when we arrived. :-) We were able to park our vehicles and walk to the bars & restaurants. The house has such a cute ambiance & feel that one day we just hung out listening to music and enjoying each other's company. We tried to see the bats but missed them. :-( I would definitely recommend renting here. Thank you, we had a wonderful weekend. "
St George Cottage

Calming coastal vibes in BSL at this beautiful dog-friendly cottage

10.0 out of 10, Exceptional, (37)
"We had an amazing time at this property! It was clean, spacious, and well-equipped with everything we needed. The outdoor area was great for relaxing, and the location was perfect—close to attractions but peaceful. The host was very responsive and made sure we had everything for a comfortable stay. Highly recommend if you are in the area! "
Calming coastal vibes in BSL at this beautiful dog-friendly cottage

Beachfront 1 bedroom on the beach in Bay St Louis. Walking distance to Main St!

10.0 out of 10, Exceptional, (134)
"Clean, easy process, and close to everything."
Beachfront 1 bedroom on the beach in Bay St Louis. Walking distance to Main St!

New Beachfront 3 Bed 2 1/2 Bath in downtown Bay St Louis in Prime Location

10.0 out of 10, Exceptional, (135)
"This is an amazing location across from the beach. It’s a beautiful property and immaculate inside with a great covered porch lookingOut onto the beach. "
New Beachfront 3 Bed 2 1/2 Bath in downtown Bay St Louis in Prime Location

Peggy Sue

10.0 out of 10, Exceptional, (33)
"We had a great time and had everything we needed. Home was so convenient to the beach. Our dog loved the fenced in yard. We will definitely be back again. Thanks Tom and Melanie "
The price is SAR 345
SAR 882 total
includes taxes & fees
24 Feb - 25 Feb
Peggy Sue

Location! Wonderful, Comfortable, Spacious House!

10.0 out of 10, Exceptional, (237)
"Cozy cottage and great gathering spaces for us. Loved the screened in porch."
Location! Wonderful, Comfortable, Spacious House!

Yellow Door Cottage In The Heart of Bay St. Louis

10.0 out of 10, Exceptional, (69)
"House accommodated us and was lovely inside. We enjoyed walking to the bay and around town. As others have mentioned there is a train that went by several times but it didn’t bother anyone in our group as we were expecting it. Would stay here again."
Yellow Door Cottage In The Heart of Bay St. Louis

Charming Coastal Camp~Pet Friendly, Deep Water Access: Jourdan/Gulf-Private Dock

10.0 out of 10, Exceptional, (2)
"The rooms and accommodations were as described. The house has everything you need to keep the kids happy. The kitchen is fully stocked. It was very relaxing sitting out in the porch watching the kids fish. Amy was super accommodating and quick to respond to any questions or concerns. I would definitely stay there again."
Charming Coastal Camp~Pet Friendly, Deep Water Access: Jourdan/Gulf-Private Dock

“Prime Location” New Beachfront 3 Bedroom on the BEACH in downtown Bay St Louis

10.0 out of 10, Exceptional, (104)
"Property is exactly as pictured & described here. Fun to walk 1/2 mile into old town for restaurants & shops."
“Prime Location” New Beachfront 3 Bedroom on the BEACH in downtown Bay St Louis

HEATED POOL, Hot Tub, BOAT/FISH DOCK, Gourmet Kitchen, Pet and Family Friendly

9.8 out of 10, Exceptional, (198)
"We rented this property for a week to combine wedding and honeymoon. This was a lovely place to host a small wedding and reception. A beautiful home with lots of space and plenty to do in the area. "
HEATED POOL, Hot Tub, BOAT/FISH DOCK, Gourmet Kitchen, Pet and Family Friendly

Sunset bay view 1

10.0 out of 10, Exceptional, (96)
"This is an amazing property. Semi secluded, beautiful home and gorgeous views"
Sunset bay view 1

Farmhouse charm + Bunkhouse. Fishing. Hot tub. Outdoor TV.

9.6 out of 10, Exceptional, (25)
"It is a well loved old farm house, with dated but comfortable furniture and appliances. Upon arrival there was a noticeable smell (we just purchased an odor eliminating air freshener to cover). The bunk house had a musty off-putting smell, so we opted not to use it. We didn't use the hot tub as we couldn't figure out how to turn it on/off. It is a no outlet street that is very busy. The traffic greatly exceeded the 20mph speed limit. We also encountered a gentleman on a golf cart who went by...
Farmhouse charm + Bunkhouse. Fishing. Hot tub. Outdoor TV.

Quiet Northshore Retreat a few miles from Lake Pontchartrain’s shoreline!

2.0 star property
9.4 out of 10, Exceptional, (8)
"The place was a perfect location for us. It had plenty of room for my family. The house was pretty inside and out. "
Quiet Northshore Retreat a few miles from Lake Pontchartrain’s shoreline!

2 mi to Old Town ★ Blocks to ⛱️ ★Spacious & Cozy

10.0 out of 10, Exceptional, (56)
"Loved the place!! Very clean and beautiful 3 bedroom house! "
2 mi to Old Town ★ Blocks to ⛱️ ★Spacious & Cozy

Old Town Charm ~ Step Back In Time ~ Walk To The Beach

9.8 out of 10, Exceptional, (71)
"Property in ideal location that allowed for us to walk to downtown. Fenced in back yard was ideal for our dog. Weather was too cold to utilize outdoor decks. But they looked very inviting. "
The price is SAR 600
SAR 1,308 total
includes taxes & fees
17 Feb - 18 Feb
Old Town Charm ~ Step Back In Time ~ Walk To The Beach

Private home on the water w/pool -minutes from the beach and downtown fun!!

9.8 out of 10, Exceptional, (100)
"Water was low at pier but our boat was able to dock all week. Lots of comfortable seating area and ease to downtown beach area. Mattresses were 5 stars. "
Private home on the water w/pool -minutes from the beach and downtown fun!!

Cozy Cottage with Guest House, Gazebo and Deck

9.8 out of 10, Exceptional, (44)
"The host Merry was super informative and kept us in the loop when is SNOWED in Louisiana (never happens). All was good at the house though thank goodness. Easy directions to get in. The heat worked fantastic (not always the case in older homes) and the bed was super comfortable. We are going back in December and are going to book this house again!"
Cozy Cottage with Guest House, Gazebo and Deck
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Other property types in Picayune

Cozy barn apartment great for travel nurses in South Mississippi Gulf Coast area

10.0 out of 10, Exceptional, (2)
"I stayed here for the weekend while attending The Superbowl and the commute was a little distance away but wasn’t too far. The host was very communicative & considerate during my stay. She provided snacks & water and left courteous notes. I would recommend others to stay!!"
Cozy barn apartment great for travel nurses in South Mississippi Gulf Coast area

New Beachfront 3 Bed 2 1/2 Bath in downtown Bay St Louis in Prime Location

10.0 out of 10, Exceptional, (135)
"This is an amazing location across from the beach. It’s a beautiful property and immaculate inside with a great covered porch lookingOut onto the beach. "
New Beachfront 3 Bed 2 1/2 Bath in downtown Bay St Louis in Prime Location

Cozy room .4 mile walk to beautiful seawall over looking the Bay of Saint Louis.

9.4 out of 10, Exceptional, (22)
"Perfect spot, with a clean a cozy room. Would definitely stay here again! "
The price is SAR 244
SAR 443 total
includes taxes & fees
17 Feb - 18 Feb
Cozy room .4 mile walk to beautiful seawall over looking the Bay of Saint Louis.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.