Photo by Corey Dargan
Find Business Hotels in Orangeburg, SC
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on Orangeburg Business Hotels
Tonight
Tomorrow
This weekend
Next weekend
Compare Orangeburg Business Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Baymont by Wyndham Orangeburg North
Baymont by Wyndham Orangeburg North
6.2 out of 10, (1000)
The price is SAR 293
SAR 325 total
includes taxes & fees
4 May - 5 May

Hampton Inn Santee-I-95
Hampton Inn Santee-I-95
9.6 out of 10, Exceptional, (998)
The price is SAR 512
SAR 568 total
includes taxes & fees
26 May - 27 May

Spark by Hilton Orangeburg
Spark by Hilton Orangeburg
7.6 out of 10, Good, (974)
The price is SAR 411
SAR 457 total
includes taxes & fees
26 May - 27 May

Hampton Inn & Suites Orangeburg
Hampton Inn & Suites Orangeburg
9.4 out of 10, Exceptional, (690)
The price is SAR 507
SAR 563 total
includes taxes & fees
26 May - 27 May

Econo Lodge
Econo Lodge
6.4 out of 10, (307)
The price is SAR 255
SAR 283 total
includes taxes & fees
15 May - 16 May

Southern Lodge
Southern Lodge
6.8 out of 10, (137)

Super 8 by Wyndham, Orangeburg
Super 8 by Wyndham, Orangeburg
6.6 out of 10, (790)
The price is SAR 250
SAR 277 total
includes taxes & fees
7 May - 8 May

Best Western Plus Santee Inn
Best Western Plus Santee Inn
8.8 out of 10, Excellent, (1000)
The price is SAR 430
SAR 478 total
includes taxes & fees
18 May - 19 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find out more about Orangeburg
Find out more about Orangeburg
Recent reviews of Orangeburg hotels
Recent reviews of Orangeburg hotels

Holiday Inn Express & Suites Orangeburg by IHG
5/5 Excellent
"The breakfast was on point stayed 2 nights. Customer service from the front desk to housekeeping was great. They had the best oatmeal served at any hotel u have stayed at."
A verified traveler stayed at Holiday Inn Express & Suites Orangeburg by IHG
Posted 3 days ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Find More Hotels near Orangeburg
More Hotel Options in Orangeburg
- Adults Only Resorts & Hotels in Orangeburg
- Adventure Hotels in Orangeburg
- Beach Hotels in Orangeburg
- Cheap Hotels in Orangeburg
- Family Hotels in Orangeburg
- Golf Hotels in Orangeburg
- Historic Hotels in Orangeburg
- Hotel with a Concierge in Orangeburg
- Hotels with Bars in Orangeburg
- Hotels with Free Parking in Orangeburg
- Hotels with Hot Tubs in Orangeburg
- Hotels with WiFi in Orangeburg
- Hotels with a Pool in Orangeburg
- Hotels with an Indoor Pool in Orangeburg
- Hotels with smoking rooms in Orangeburg
- Luxury Hotels in Orangeburg
- Pet-friendly Hotels in Orangeburg
- Resorts & Hotels with Spas in Orangeburg
- Romantic Hotels in Orangeburg
- Shopping Hotels in Orangeburg
More Accommodation Types in
- Condo Rentals in South Carolina
- Vacation Homes in South Carolina
- Apartments in South Carolina
- Villas in South Carolina
- Resorts in South Carolina
- Cottages in South Carolina
- Cabin Rentals in South Carolina
- Aparthotels in South Carolina
- Motels in South Carolina
- Guest Houses in South Carolina
- B&B in South Carolina
- Lodges in South Carolina
- Condo Resorts in South Carolina
- Houseboats in South Carolina
- Inns in South Carolina
- Country Houses in South Carolina
- Hostels in South Carolina
Hotels near popular Orangeburg Attractions
- Hotels near Edisto Memorial Gardens
- Hotels near Congaree National Park
- Hotels near Santee State Park
- Hotels near South Carolina State University
- Hotels near Santee Cooper Country Club
- Hotels near God's Acre Healing Springs
- Hotels near Santee Outlets
- Hotels near Santee National Golf Club
- Hotels near Santee National Wildlife Refuge
- Hotels near Harry Hampton Visitor Center
Orangeburg Hotels by Star Rating
Explore more hotels
- Comfort Inn & Suites
- Quality Inn & Suites
- Sleep Inn Orangeburg
- Days Inn by Wyndham Orangeburg South
- Orangeburg Inn & Suites
- Suburban Studios
- Nene’s Cozy Corner
- Crown Inn By Oyo Orangeburg Hwy 301
- Secluded Cabin Retreat with Hot Tub, for Family Get Away Pond dam busted
- Centally located w/ coffee bar, theatre/gameroom
- Baymont by Wyndham Santee
- Days Inn by Wyndham St George
- Tru By Hilton Santee
- Fairfield Inn & Suites by Marriott Santee
- Holiday Inn Santee by IHG
- Hampton Inn Santee-I-95
- Comfort Inn & Suites Santee
- Best Western Plus Santee Inn
- Quality Inn & Suites
- Travelodge by Wyndham Santee