Photo by Dr__Vlad
Find hotels in O Brien, FL from SAR 225
- Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check prices for these dates
Tonight
Tomorrow
This weekend
Next weekend
Compare 314 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Hampton Inn & Suites Alachua I-75
Hampton Inn & Suites Alachua I-75
9.4 out of 10, Exceptional, (386)
The price is SAR 443
SAR 499 total
includes taxes & fees
13 Apr - 14 Apr

Americas Best Value Inn Alachua
Americas Best Value Inn Alachua
4.8 out of 10, (533)
The price is SAR 316
SAR 355 total
includes taxes & fees
18 Mar - 19 Mar

Royal Inn
Royal Inn
7.2 out of 10, Good, (169)
The price is SAR 293
SAR 329 total
includes taxes & fees
18 Mar - 19 Mar

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
9.2 out of 10, Wonderful, (1002)
The price is SAR 497
SAR 559 total
includes taxes & fees
13 Apr - 14 Apr

Vista Verde Farm Retreat
Vista Verde Farm Retreat
10.0 out of 10, Exceptional, (1)
The price is SAR 472
SAR 695 total
includes taxes & fees
25 Mar - 26 Mar

BlueGem Motel
BlueGem Motel
9.2 out of 10, Wonderful, (338)
The price is SAR 375
SAR 422 total
includes taxes & fees
24 Mar - 25 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Learn more about O Brien
Explore attractions like Suwannee River and Ichetucknee River as you discover things to see and do in O Brien.

Photo by Dr__Vlad
Open Photo by Dr__Vlad
More cheap stays in O Brien
More cheap stays in O Brien

La Quinta Inn & Suite by Wyndham Lake City
165NW CALI DRIVE, Lake City, FL
The price is SAR 413 per night from Mar 30 to Mar 31
SAR 413
SAR 464 total
includes taxes & fees
30 Mar - 31 Mar
8.8/10 Excellent! (1,002 reviews)
Hotels in O Brien with star-rating
Hotels in O Brien with star-rating

3 Star Hotels
18 properties
Recent reviews of O Brien hotels
Recent reviews of O Brien hotels

Fairfield Inn & Suites Lake City
5/5 Excellent
"Pleasant hotel. Kristy put together a yummy breakfast bar. "
A verified traveler stayed at Fairfield Inn & Suites Lake City
Posted 2 days ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Stay near popular O Brien attractions
- Hotels near Ichetucknee Springs State Park
- Hotels near Ginnie Spring
- Hotels near Ruth B. Kirby Gilchrist Blue Springs State Park
- Hotels near Suwannee River State Park
- Hotels near Ichetucknee River
- Hotels near Santa Fe River
- Hotels near O'Leno State Park
- Hotels near Southside Sports Complex
- Hotels near North Florida Speedway
- Hotels near Poe Springs Park
- Hotels near Lake City Mall
- Hotels near Southside Recreation Complex
- Hotels near Lake City Veterans Affairs Medical Center
- Hotels near Columbia County Courthouse
- Hotels near Florida Department of Transportation
- Hotels near Stephen Foster Folk Culture Center
- Hotels near Wes Skiles Peacock Springs State Park
- Hotels near Big Shoals State Park
- Hotels near Stephen Foster State Folk Center
- Hotels near Lafayette Blue Springs State Park
More Accommodation Types in O Brien
O Brien Hotels by Brand
Other Hotels near O Brien, Florida
- Florida Panhandle Hotels
- Lake City Hotels
- Jasper Hotels
- Gulf Coast Hotels
- Alachua Hotels
- Perry Hotels
- High Springs Hotels
- Live Oak Hotels
- Madison Hotels
- Newberry Hotels
- Old Town Hotels
- Central West Coast Florida Hotels
- Fort White Hotels
- Northern Florida Hotels
- Southeastern United States Hotels
- Trenton Hotels
- Branford Hotels
- Mayo Hotels
- Lake Butler Hotels
- White Springs Hotels
Explore more hotels
- Americas Best Value Inn Alachua
- Quality Inn Lake City
- Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
- Best Western Plus Lake City
- Holiday Inn Express Hotel & Suites LIVE OAK by IHG
- Hampton Inn & Suites Alachua I-75
- Postcard Cabins Gilchrist Springs
- BlueGem Motel
- Baymont by Wyndham Lake City
- Quality Inn White Springs Suwanee
- Days Inn by Wyndham Lake City I-10
- Comfort Suites Lake City