Search Vacation Homes in Lake City

    calendar shield illustration
    Change your mind
    Book hotels with free cancellation
    deals illustration
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    bed illustration
    Be picky
    Search almost a million properties worldwide

Check prices for these dates

Compare 15 Vacation Homes in Lake City with updated reviews, rates, and availability.

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

10.0 out of 10, Exceptional, (20)
"Home was really clean! Exactly as pictured. Host was very responsive and welcoming. New neighborhood, very quiet. This is exactly what you always dream a VRBO will be. "
The price is SAR 705
SAR 1,231 total
includes taxes & fees
28 Apr - 29 Apr
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Pineapple House: Historic. Southern Charm. Walk Downtown.

9.6 out of 10, Exceptional, (14)
"It is a beautiful house, Everything we needed was there already. And bonus points from me because it's in a perfect location. We hope to return in the future."
Pineapple House: Historic. Southern Charm. Walk Downtown.

Cheerful home with plenty of privacy and entertainment room.

8.2 out of 10, Very Good, (24)
"We had a wonderful stay. Three couples in for the race, house was perfect. "
Cheerful home with plenty of privacy and entertainment room.

Hickory Haven 3Br Elegant Downtown Hidden Gem

9.6 out of 10, Exceptional, (14)
"The accuracies of the reviews for this property are all on point. It is a beautifully remodeled bungalow in Historic Florence. The touches are all very elegantly and tastefully done. All the technology inside the house was easy to figure out, and it was very quiet and peaceful. The only negative feedback I would leave is that it would be really nice if the neighbors would put a bit more care into the appearance of their properties, and especially the neighbor across the street, who has...
Hickory Haven 3Br Elegant Downtown Hidden Gem

Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

10.0 out of 10, Exceptional, (4)
"The host response time is quick and she did great accommodating our needs! Very clean and welcoming, will definitely refer family and friends. "
Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

Simple & Sweet 2-bedroom house in amazing Florence

8.0 out of 10, Very Good, (1)
"Upon arrival the heater was not working. We sent a message and got a response very quickly. A repairman was sent and the problem was fixed. The beds were comfortable and the rooms were large. We plan to stay here again when we come back in town."
Simple & Sweet 2-bedroom house in amazing Florence

Quaint Bungalow in Historic Downtown Florence

10.0 out of 10, Exceptional, (13)
"Very clean, quite home. everything you need for an extended stay. "
Quaint Bungalow in Historic Downtown Florence

Great Home in the Greater Florence Area

9.6 out of 10, Exceptional, (5)
"Nice location and home. Owner was very responsive and accommodating. Matt promptly addressed our initial concerns after checkin. I would consider this home again for potential future bookings. "
Great Home in the Greater Florence Area

Elegant Historic Home w/ Modern Touch in Florence

Elegant Historic Home w/ Modern Touch in Florence

Charming 3-bedroom home in Florence nea downtown, McLeod and MUSC hospitals.

10.0 out of 10, Exceptional, (2)
"Our host David is wonderful and he accommodated us over the holidays with some short notice. The property is very clean and well kept. Check in and out was easy. There are plenty of towels and the kitchen has everything you’d need for a comfortable stay. I appreciated how easy it was to communicate with David during our stay. Thank you again!!"
Charming 3-bedroom home in Florence nea downtown, McLeod and MUSC hospitals.

Walking distance from one of South Carolina's top Medical centers.

9.8 out of 10, Exceptional, (37)
"Florence is the perfect half way point to meet with friends. The house was the perfect size , comfortable, and had everything we needed. I'm sure we will be back. "
The price is SAR 559
SAR 954 total
includes taxes & fees
28 Apr - 29 Apr
Walking distance from one of South Carolina's top Medical centers.

Charming 3-bedroom house in Florence, SC

Charming 3-bedroom house in Florence, SC

Charming 2 bedroom near downtown

The price is SAR 806
SAR 1,391 total
includes taxes & fees
15 May - 16 May
Charming 2 bedroom near downtown

Luxury stay at 4 bedroom house

9.0 out of 10, Wonderful, (2)
"We went to Florence for a family reunion and wanted a place close by. The house is fine but slightly strange in its decor. It's perfectly fine, safe, and the host responds to questions very quickly,"
Luxury stay at 4 bedroom house

Charming Farm House on 45 Acres

Charming Farm House on 45 Acres

Work Friendly House Downtown Florence

Work Friendly House Downtown Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Lake City
Save an average of 15% on thousands of hotels when you're signed in

Other property types in Lake City

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

10.0 out of 10, Exceptional, (20)
"Home was really clean! Exactly as pictured. Host was very responsive and welcoming. New neighborhood, very quiet. This is exactly what you always dream a VRBO will be. "
The price is SAR 705
SAR 1,231 total
includes taxes & fees
28 Apr - 29 Apr
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Cheerful home with plenty of privacy and entertainment room.

8.2 out of 10, Very Good, (24)
"We had a wonderful stay. Three couples in for the race, house was perfect. "
Cheerful home with plenty of privacy and entertainment room.

Simple & Sweet 2-bedroom house in amazing Florence

8.0 out of 10, Very Good, (1)
"Upon arrival the heater was not working. We sent a message and got a response very quickly. A repairman was sent and the problem was fixed. The beds were comfortable and the rooms were large. We plan to stay here again when we come back in town."
Simple & Sweet 2-bedroom house in amazing Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.