Find Luxury Hotels in Destin, FL

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Compare Destin Luxury Hotels room rates, reviews, and availability. Most hotels are fully refundable.

Capitano 7 Bedroom Holiday Home by Five Star Properties

5.0 star property
Capitano 7 Bedroom Holiday Home by Five Star Properties

Caribbean Queen 5 Bedroom Holiday Home by Five Star Properties

4.5 star property
Caribbean Queen 5 Bedroom Holiday Home by Five Star Properties

Destination Fun 9 Bedroom Holiday Home by Five Star Properties

4.5 star property
Destination Fun 9 Bedroom Holiday Home by Five Star Properties

Just the Ticket 4 Bedroom Holiday Home by Five Star Properties

4.5 star property
Just the Ticket 4 Bedroom Holiday Home by Five Star Properties

Mermaid Vista 5 Bedroom Holiday Home by Five Star Properties

4.5 star property
Mermaid Vista 5 Bedroom Holiday Home by Five Star Properties

Millenia 7 Bedroom Holiday Home by Five Star Properties

5.0 star property
Millenia 7 Bedroom Holiday Home by Five Star Properties

Ocean Paradise 4 Bedroom Holiday Home by Five Star Properties

4.5 star property
Ocean Paradise 4 Bedroom Holiday Home by Five Star Properties

Palazzo del Mar 11 Bedroom Holiday Home by Five Star Properties

5.0 star property
Palazzo del Mar 11 Bedroom Holiday Home by Five Star Properties

Sea E O 11 Bedroom Holiday Home by Five Star Properties

4.5 star property
Sea E O 11 Bedroom Holiday Home by Five Star Properties

Son Kissed 4 Bedroom Holiday Home by Five Star Properties

4.5 star property
Son Kissed 4 Bedroom Holiday Home by Five Star Properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to Destin?
During your visit, you might want to enjoy the beaches and shopping which Destin is known for.
What's the best high-end hotel in Destin?
The Henderson Beach Resort & Spa is a luxury resort with a private beach and 4 restaurants, and it’s a popular choice for Expedia travelers looking for an elegant place to stay.
How many luxury hotels are there in Destin?
Lie in the lap of luxury during your getaway to Destin in one of Expedia’s 10 luxury hotels.
When can I expect good weather in Destin?
Planning for the weather is an important factor for making your trip to Destin a success, especially when you’re splurging. The hottest months are usually August and July with an average temp of 82°F, while the coldest months are January and February with an average of 58°F. The rainiest months in Destin are August, July, December, and June, with each month seeing an average of 7 inches of rainfall.
What's there to see and do in Destin?
Experience Destin with a stop at Big Kahuna’s Water and Adventure Park, Henderson Beach, and Henderson Beach State Park. If you have a little extra time during your trip, you might want to make a stop at Destin Beaches and Destin Commons.