Photo by Hideki Yamagata

Find Resorts & Hotels with Spas in San Francisco

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Check availability on San Francisco Resorts & Hotels with Spas

Compare San Francisco Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Sheraton Grand Panama

4.0 star property
8.6 out of 10, Excellent, (868)
"Great place to stay"
The price is SAR 500
SAR 549 total
includes taxes & fees
20 May - 21 May
Sheraton Grand Panama

JW Marriott Panama

5.0 star property
8.8 out of 10, Excellent, (1002)
"Excellent location "
The price is SAR 897
SAR 987 total
includes taxes & fees
31 May - 1 Jun
JW Marriott Panama

Aloft Panama

3.5 star property
8.6 out of 10, Excellent, (802)
"Great place to stay if your traveling with family."
The price is SAR 452
SAR 497 total
includes taxes & fees
13 May - 14 May
Aloft Panama

Plaza Paitilla Inn Hotel

3.5 star property
9.4 out of 10, Exceptional, (2026)
"Family enjoyed their stay"
The price is SAR 483
SAR 542 total
includes taxes & fees
4 May - 5 May
Plaza Paitilla Inn Hotel

Residence Inn by Marriott Panama City

4.0 star property
9.0 out of 10, Wonderful, (459)
"Great location inside Punta Pacifica Mall. Hotel is great for long stays multiple family members. Hotel staff was very accommodating. "
The price is SAR 602
SAR 663 total
includes taxes & fees
8 May - 9 May
Residence Inn by Marriott Panama City

Megapolis Hotel Panamá

4.5 star property
8.4 out of 10, Very Good, (877)
"My stay at this hotel was nothing short amazing the staff and manager were so helpful as i had arrived early. "
The price is SAR 476
SAR 524 total
includes taxes & fees
3 May - 4 May
Megapolis Hotel Panamá

Courtyard by Marriott Panama Multiplaza Mall

4.0 star property
8.8 out of 10, Excellent, (1000)
"It was quiet staff very helpful worth the stay"
The price is SAR 486
SAR 535 total
includes taxes & fees
16 May - 17 May
Courtyard by Marriott Panama Multiplaza Mall

Ramada Plaza By Wyndham Panama Punta Pacífica

4.0 star property
9.6 out of 10, Exceptional, (1003)
"Great place to stay"
The price is SAR 397
SAR 436 total
includes taxes & fees
2 Jun - 3 Jun
Ramada Plaza By Wyndham Panama Punta Pacífica

Decapolis Hotel Panama City

4.0 star property
8.6 out of 10, Excellent, (1172)
"Great location "
The price is SAR 303
SAR 333 total
includes taxes & fees
19 May - 20 May
Decapolis Hotel Panama City

Diaphanous Urban Apartment

3.5 star property
9.2 out of 10, Wonderful, (5)
"I highly highly recommend this apartment. Best AC you will find In panama. Very clean, spacious, everything worked as it should. This is now my go to place while visiting Panama. The dining options are vast and close. Many top restaurants are near by. And parque Omar for your morning walks. Pet friendly. Don’t look elsewhere. "
Diaphanous Urban Apartment
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in San Francisco?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Be sure to enjoy the many popular restaurants during your stay. Hotels with spas are a great way to break away from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in San Francisco?
Megapolis Hotel Panamá is a top luxury spa hotel featuring 3 bars, a casino, a shopping mall, and a rooftop terrace. Enjoy a facial, body scrub, or detox wrap at the onsite spa. Other popular spa hotels in San Francisco include Decapolis Hotel Panama City and Las Americas Golden Tower Panama.
How many spa hotels will I find in San Francisco?
Among Expedia’s 197 accommodation options in San Francisco, there are 4 spa hotels.
What's there to see and do in San Francisco?
Enjoy San Francisco and visit Multiplaza Pacific Mall, Calle 50, and Avenida Balboa. If you have spare time during your trip, you might want to make a stop at Panama Canal Murals and Pacific Center.
What is a San Francisco spa hotel?
Spa hotels in San Francisco provide lodging and have an on-site spa which offers services like therapies and body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.