Otay Mesa West Vacations

Book a Hotel + Flight together to unlock savings

  • Plan, book, travel with confidence

    • payments icon
    Better together
    Save up to SAR 390 when you book a flight and hotel together*
    lob hotels icon
    Find the right fit
    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon
    Rest easy
    Plan, book, and manage your trip all in one place

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa West
US Grant Hotel

Downtown San Diego

3 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Otay Mesa West Hotel Deals

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is SAR 496 per night from Apr 20 to Apr 21
SAR 496
SAR 558 total
includes taxes & fees
20 Apr - 21 Apr
7.8/10 Good! (1,426 reviews)
"Great staff spacious room. Great breakfaat"

Reviewed on 3 April 2025

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is SAR 709 per night from Apr 20 to Apr 21
SAR 709
SAR 969 total
includes taxes & fees
20 Apr - 21 Apr
8.2/10 Very Good! (1,159 reviews)
"All of the staff were very happy, friendly and helpful. Would stay again."

Reviewed on 5 April 2025

San Diego Mission Bay Resort
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is SAR 571 per night from Apr 19 to Apr 20
SAR 571
SAR 643 total
includes taxes & fees
19 Apr - 20 Apr
8.2/10 Very Good! (5,649 reviews)
"Rooms are clean and comfortable, Service is great. Just a note that though there is a free shuttle service to the airport but it only begins at 6 AM so if your flight leaves early, you will have to get your own Uber or taxi."

Reviewed on 3 April 2025

Wyndham San Diego Bayside
See all 6,539 properties in Otay Mesa West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Otay Mesa West

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

4.5/5(3,565 reviews)

Why not visit the animals who live at San Diego Zoo and see why this is a favorite attraction in San Diego? Stroll along the area's seaside or experience its acclaimed theater scene.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

4.5/5(1,297 reviews)

During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and acclaimed art scene.

San Diego Convention Center
Mission Bay featuring a sandy beach

Mission Bay

4.5/5(2,386 reviews)

Explore the great outdoors at Mission Bay, a popular spot to commune with nature in San Diego. Stroll along the seaside in this family-friendly area, or check out its top-notch restaurants.

Mission Bay