Search Vacation Homes in Main Street Hyannis

  • Plan, book, stay with confidence

  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check prices for these dates

Next weekend
In two weeks
In one month

Compare 2341 Vacation Homes in Main Street Hyannis with updated reviews, rates, and availability.

Darling Cape Cottage - Steps from Downtown Harwich Port

10.0 out of 10, Exceptional, (52)
"Immaculate home with Cape Cod charm! Fabulous location. Excellent communication with Michael. Quick response to questions. Would absolutely stay again."
Darling Cape Cottage - Steps from Downtown Harwich Port

Sweet Pea Cottage - Previous 4.9 rating relisted!

10.0 out of 10, Exceptional, (2)
"The Sweet Pea Cottage was beautiful. Very nicely but simply decorated. Once I got the Heat going it was cozy and comfortable. The TV was easy to use and the bed was so nice. I stayed here with my dog and it was the perfect fit for us. Communication with the host was also very easy And Timely. We will definitely be coming back."
The price is SAR 469
SAR 1,099 total
includes taxes & fees
25 Jan - 26 Jan
Sweet Pea Cottage - Previous 4.9 rating relisted!

Cape Cod cottage

9.6 out of 10, Exceptional, (95)
"House was very clean. Nicely decorated. Peaceful. Has everything you may need. Check in and check out was smooth. I even walked in to a nice little surprise. Highly recommend."
Cape Cod cottage

Waterfront, Incredible Views and Private Dock!

9.4 out of 10, Exceptional, (3)
"Location was great for us. Beds were very clean and comfortable and many bedrooms. Kitchen view was amazing and appliances worked well. Overall, very nice, quiet vacation home. "
Waterfront, Incredible Views and Private Dock!

Waterfront on Lake! 6 bd, 2 bth. Central Air. Huge Deck. Paddle boat!

10.0 out of 10, Exceptional, (22)
"Thank you Thomas and Julie, had a great week, so convenient and Welcoming. "
Waterfront on Lake! 6 bd, 2 bth. Central Air. Huge Deck. Paddle boat!

Coastal Cape Cod 3 bedroom close to the beach, bike path & ponds!

2.0 star property
10.0 out of 10, Exceptional, (5)
"This is rental has become my #1 vacation home. I absolutely love this home. The host is awesome & a delight to correspond with. I will be back again! "
The price is SAR 563
SAR 2,700 total
includes taxes & fees
29 Jan - 30 Jan
Coastal Cape Cod 3 bedroom close to the beach, bike path & ponds!

Welcoming dog-friendly 5-bedroom retreat just across from SeaView Beach!

9.8 out of 10, Exceptional, (114)
"It was difficult with 7 women staying there & only 2 bathrooms."
Welcoming dog-friendly 5-bedroom retreat just across from SeaView Beach!

Sleeps 14 Home w/ Pool Great for Families!

9.6 out of 10, Exceptional, (4)
"The property slept 12 people with two beds extra comfortably."
Sleeps 14 Home w/ Pool Great for Families!

Large New Seabury Home with Heated Pool and Hot Tub

10.0 out of 10, Exceptional, (39)
"We stayed for a week over the Christmas holidays. The house easily accommodated our group of eight people and one dog. We enjoyed the easy walk to the National Wildlife Refuge and a quick drive for winter beach walks. We enjoyed spending time with a roaring fire and a few dips in the hot tub. Tori was very responsive to the couple of issues that arose. "
Large New Seabury Home with Heated Pool and Hot Tub

Quaint cottage 100 steps from the Beach

10.0 out of 10, Exceptional, (50)
"A charming spot near the ocean. We (adults, kids and a toddler) had a blast. Host was great too!"
Quaint cottage 100 steps from the Beach

Estate with Private pool, tennis court, and playground!

Estate with Private pool, tennis court, and playground!

Beautiful Great Island Ocean Club Home (2368)

10.0 out of 10, Exceptional, (4)
"Our stay here was nothing but amazing! The house was clean and beautiful. A 2 min walk to the beach and pool. Loaded with beach chairs and beach toys/floats. They also had a ping pong table, cornhole, basketball and a bunch of other games. Check in was very easy and convenient. Definitely recommend! "
Beautiful Great Island Ocean Club Home (2368)

The Parsonage - 1870 Victorian in Sandwich Village

2.0 star property
The Parsonage - 1870 Victorian in Sandwich Village

Coastal Family Retreat

Coastal Family Retreat

Family-Friendly Beach House

Family-Friendly Beach House

Coastal chic meets French Provençal in this newly renovated oceanfront home.

10.0 out of 10, Exceptional, (74)
"Beautiful home and views"
The price is SAR 1,872
SAR 4,384 total
includes taxes & fees
31 Jan - 1 Feb
Coastal chic meets French Provençal in this newly renovated oceanfront home.

Cheery house with deck, sunroom & patio - short walk to pond, beach & Rail Trail

9.6 out of 10, Exceptional, (37)
"My family and I rented this beautiful home for a week-long getaway in August, and we couldn't have been more pleased with our experience. The location was absolutely perfect - just a short distance from a scenic bike trail that we took advantage of for our daily runs and bike rides. The house itself was stunning and immaculately clean. We were impressed by how well-maintained and cared for the property was. The neighborhood was quiet and peaceful, and we enjoyed being able to take a short walk...
The price is SAR 495
SAR 1,967 total
includes taxes & fees
26 Jan - 27 Jan
Cheery house with deck, sunroom & patio - short walk to pond, beach & Rail Trail

Cozy Cape home with outdoor shower and deck - minutes to beach

9.8 out of 10, Exceptional, (62)
"The housebwas beautiful! A girls weekend to experience tge Christmas Stroll. Thank you!!"
Cozy Cape home with outdoor shower and deck - minutes to beach

Beachfront On John's Pond, Indoor HEATED Pool, and Dock!

9.6 out of 10, Exceptional, (82)
"Wonderful property on the pond. We had a great time. Would rent again. "
Beachfront On John's Pond, Indoor HEATED Pool, and Dock!

Ocean Views From Every Room, Beach 30 Seconds Away!

10.0 out of 10, Exceptional, (101)
"Our three generation family has gathered together in California every Thanksgiving week for decades. This year, since our eldest granddaughter is an ob/gyn resident at Brown, we decided to save her a trip and stay on the Cape. We all loved our stay — watching the tides, cooking together. Some of us taking long walks, and visiting with longtime friends who live in the area. The perfect reunion."
Ocean Views From Every Room, Beach 30 Seconds Away!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in Main Street Hyannis
Save an average of 15% on thousands of hotels when you're signed in

Other property types in Main Street Hyannis

Courtyard Resort

3.0 star property
8.4 out of 10, Very Good, (49)
"Great for short or extended stay. "
The price is SAR 260
SAR 297 total
includes taxes & fees
28 Jan - 29 Jan
Courtyard Resort

The Cove At Yarmouth

3.0 star property
9.2 out of 10, Wonderful, (220)
"This is my wife and my favorite spot to just come and relax in the off season and get some great hot chocolates from our favorite bakery in town. "
The price is SAR 484
SAR 554 total
includes taxes & fees
26 Jan - 27 Jan
The Cove At Yarmouth

Waterfront 5-Bed 2-Bath Retreat

8.0 out of 10, Very Good, (3)
"Location was great. Very clean."
Waterfront 5-Bed 2-Bath Retreat
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.