You'll enjoy the museums and parks in Zona Centro. You might want to make time for a stop at Saltillo Casino or Santiago Cathedral.
If you're looking for some top things to see and do in Centenario and surrounding area, you can visit Saltillo Casino and Museum of the Desert.
When in La Misión, you can plan a visit to San Felipe Springs and Val Verde Winery, some noteworthy sights in the nearby area.