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Find All Southwest Illinois Hotels
We have found 637 Southwest Illinois Hotels
- Hilton Garden Inn St. Louis Airport
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Embassy Suites by Hilton St. Louis Airport
- Drury Inn & Suites Cape Girardeau
- Drury Inn & Suites Sikeston, MO
- The Lodge at Grant's Trail
- Red Roof Inn St Louis - Westport
- Hotel Indigo St. Louis - Downtown by IHG
- Courtyard St. Louis Airport/Earth City
- Holiday Inn Express Metropolis by IHG
- Comfort Inn St. Louis - Westport Event Center
- Best Western Plus Fenton
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Fairfield Inn & Suites by Marriott St. Louis South
- Fairfield Inn & Suites St Louis Westport
- Quality Inn
- Staybridge Suites St Louis - Westport by IHG
- Americas Best Value Inn St. Louis South
- Guest Host Motel
- Super 8 by Wyndham St. Louis Airport
- Courtyard by Marriott St. Louis West County
- The Lodge Hotel and Banquets
- Drury Inn & Suites Jackson MO
- Holiday Inn Express & Suites Perryville by IHG
- Comfort Inn Festus - St Louis South
- Hampton Inn & Suites St. Louis/South I-55
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
- MainStay Suites St Louis Airport
- Drury Inn & Suites St. Louis Arnold
- Residence Inn by Marriott St Louis Airport
- Holiday Inn Express & Suites Litchfield West by IHG
- Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
- Comfort Suites St. Louis - Sunset Hills
- SpringHill Suites by Marriott St. Louis Airport/Earth City
- Welcome Suites Hazelwood
- Sheraton Westport Chalet Hotel St. Louis
- Residence Inn by Marriott St. Louis West County
- Americas Best Value Inn St. Louis Downtown
- Baymont by Wyndham Litchfield
- Hampton Inn Cape Girardeau I 55 East
- Super 8 by Wyndham Perryville
- Seven Gables, St. Louis West, a Tribute Portfolio Hotel
- Hampton Inn St. Louis Southwest
- Town House Inn Cape Giradreau
- WoodSpring Suites St. Louis Arnold
- Silo Farm Haus- located in the heart of wine country!
- Homewood Suites by Hilton St. Louis Westport
- Cobblestone Inn & Suites - Altamont
- Super 8 by Wyndham Harrisburg
- Comfort Inn Alton near I-255
- Super 8 by Wyndham Staunton
- Microtel Inn & Suites by Wyndham Sainte Genevieve
- Benton Park Inn
- Quality Inn Festus
- Super 8 by Wyndham Metropolis
- Comfort Suites Jackson-Cape Girardeau
- Cozy, Fun, and One-Of-A-Kind!
- Hampton Inn by Hilton Litchfield
- Residence Inn St Louis Westport
- OYO Hotel St. Louis Downtown City Center MO
- Super 8 by Wyndham Charleston/Sikeston East MO
- Motel 6 Metropolis, IL
- Hotel 7 Vienna
- Comfort Inn & Suites Sikeston I-55
- Indoor Heated Pool pontoon boat fish 3 full baths sleeps 17 in beds 2025 SALE!!!
- Quality Inn Litchfield Route 66
- Country Yard Inn and Suite
- Quality Inn Perryville I-55
- Days Inn by Wyndham Perryville
- Super 8 by Wyndham Sikeston/Miner Area
- Super 8 by Wyndham Alton
- Quality Inn
- Quality Inn Charleston - Sikeston
- Motel 6 Litchfield, IL
- NEW property! Lakeside covered hot tub, A-frame 3 King Beds, Shawnee Forest
- Super 8 by Wyndham Jerseyville
- Baymont by Wyndham Metropolis
- Carlin Villa Motel
- Grand Center Inn
- BEST WAY INN
- Americas Best Value Inn Litchfield
- Rockwood Inn
- St. Louis Airport Hotel
- Tru By Hilton Cape Girardeau
- Charming, Historic Family Suite, Steps from the Chase Park Plaza and Forest Park
- Historic Red Rooster Inn
- Central West End B&B
- Illinois Historic Cross Home/Barn/Fishing/ATV/RV McLeansboro
- Shawnee - Farmhouse on 20 acres: Beautiful Views & Hot Tub!!
- Charming Home with Country Views
- Super 8 by Wyndham Pevely
- The Haven by Concord Sun Properties (PRIVATE 5BR, 2BA)
- Triangle Inn Motel
- The Weber Farm - Enjoy a beautiful 100 acre farm!